A5067981873- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Elasticity and Material Modeling
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Polymer Nanocomposites and Properties
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- biodegradable polymer synthesis and properties
- Connective tissue disorders research
- Additive Manufacturing and 3D Printing Technologies
- Cellular and Composite Structures
- Advanced Polymer Synthesis and Characterization
- Polymer crystallization and properties
- Analytical Chemistry and Sensors
- Cardiac and Coronary Surgery Techniques
- Conducting polymers and applications
- Polymer composites and self-healing
- Rheology and Fluid Dynamics Studies
- Synthesis and properties of polymers
- Mechanical Engineering and Vibrations Research
McGowan Institute for Regenerative Medicine
2016-2025
University of Pittsburgh
2016-2025
University of Palermo
2009-2025
Ri.MED
2016-2025
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2024
Fondazione FADOI
2018-2020
University of Naples Federico II
2010
University of Campania "Luigi Vanvitelli"
2010
Age-related declines in skeletal muscle regeneration have been attributed to stem cell (MuSC) dysfunction. Aged MuSCs display a fibrogenic conversion, leading fibrosis and impaired recovery after injury. Although studies demonstrated the influence of vitro substrate characteristics on fate, whether how aging extracellular matrix (ECM) affects behavior has not investigated. Here, we investigated direct effect aged ECM MuSC lineage specification. Quantification topology mechanical properties...
Whole organ engineering and cell-based regenerative medicine approaches are being investigated as potential therapeutic options for end-stage liver failure. However, a major challenge of these strategies is the loss hepatic specific function after hepatocytes removed from their native microenvironment. The objective present study was to determine if solubilized extracellular matrix (ECM), when used media supplement, can better maintain hepatocyte phenotype compared type I collagen alone or...
For applications where degradable polymers are likely to have extended blood contact, it is often important for these materials exhibit high levels of thromboresistance. This can be achieved with surface modification approaches, but such modifications may transient degradation. Alternatively, polymer design altered that the bulk thromboresistant and this maintained Toward end a series biodegradable, elastic polyurethanes (PESBUUs) containing different zwitterionic sulfobetaine (SB) content...
Elastomeric electrospun construct fabrication conditions are evaluated with regard to their effect on fiber topology and biaxial mechanical response. It is determined that alignment alone insufficient predict Moreover, intersection density introduced as a quantifiable structural measure can be manipulated achieve anisotropy similar of native soft tissues.
Tissue-engineered vascular grafts (TEVGs) poised for regenerative applications are central to effective repair, with their efficacy being significantly influenced by scaffold architecture and the strategic distribution of bioactive molecules either embedded within or elicited from responsive tissues. Despite substantial advancements over recent decades, a thorough understanding critical cellular dynamics clinical success remains be fully elucidated. Graft failure, often ascribed...
Many preclinical evaluations of autologous small-diameter tissue-engineered vascular grafts (TEVGs) utilize cells from healthy humans or animals. However, these models hold minimal relevance for clinical translation, as the main targeted demographic is patients at high cardiovascular risk such individuals with diabetes mellitus elderly. Stem adipose-derived mesenchymal stem (AD-MSCs) represent a clinically ideal cell type TEVGs, can be easily and plentifully harvested offer regenerative...
Native semi-lunar heart valves are composed of a dense fibrous network that generally follows curvilinear path along the width leaflet. Recent models engineered valve leaflets have predicted such fiber orientations would homogenize strain field and reduce stress concentrations at commissure. In present work, method was developed to reproduce this alignment in electrospun scaffolds by varying geometry collecting mandrel. Elastomeric poly(ester urethane)urea onto rotating conical mandrels...
Radiation therapy (RT) is essential for triple negative breast cancer (TNBC) treatment. However, patients with TNBC continue to experience recurrence after RT. The role of the extracellular matrix (ECM) irradiated tissue in tumor still unknown. In this study, we evaluated structure, molecular composition, and mechanical properties murine mammary fat pads (MFPs) developed ECM hydrogels from decellularized tissues (dECM) assess effects RT-induced changes on cell behavior. Irradiated MFPs were...