A5026386477- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Elasticity and Material Modeling
- Hernia repair and management
- Bone Tissue Engineering Materials
- Cardiac Valve Diseases and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Ultrasound Imaging and Elastography
- Advanced Sensor and Energy Harvesting Materials
- Ultrasound and Hyperthermia Applications
- Wound Healing and Treatments
- Pelvic and Acetabular Injuries
- Urological Disorders and Treatments
- Abdominal Surgery and Complications
- Bone fractures and treatments
- Collagen: Extraction and Characterization
- Conducting polymers and applications
- Surgical Sutures and Adhesives
- Polymer Surface Interaction Studies
- Cellular Mechanics and Interactions
- Advanced materials and composites
- Tribology and Lubrication Engineering
- Cellular and Composite Structures
- Injection Molding Process and Properties
- Mechanical Engineering and Vibrations Research
University of Pittsburgh
2010-2018
McGowan Institute for Regenerative Medicine
2010-2018
Specialty Materials (United States)
2008
Surgical mesh devices composed of synthetic materials are commonly used for ventral hernia repair. These provide robust mechanical strength and quickly incorporated into host tissue; factors that contribute to reduced recurrence rates. However, such cause a foreign body response with the associated complications fibrosis patient discomfort. In contrast, surgical naturally occurring extracellular matrix (ECM) constructive tissue remodeling, but lack materials. A method applying porcine dermal...
Elastomeric electrospun construct fabrication conditions are evaluated with regard to their effect on fiber topology and biaxial mechanical response. It is determined that alignment alone insufficient predict Moreover, intersection density introduced as a quantifiable structural measure can be manipulated achieve anisotropy similar of native soft tissues.
A biodegradable elastomeric scaffold was created by electrospinning a mixed solution of poly(ester urethane)urea (PEUU) and porcine dermal extracellular matrix (dECM) digest, with PEUU included to provide elasticity, flexibility, mechanical support dECM used enhance bioactivity biocompatibility. Micrographs differential scanning calorimetry demonstrated partial miscibility between dECM. With greater content, scaffolds were found possess lower breaking strains suture retention strength,...
Native semi-lunar heart valves are composed of a dense fibrous network that generally follows curvilinear path along the width leaflet. Recent models engineered valve leaflets have predicted such fiber orientations would homogenize strain field and reduce stress concentrations at commissure. In present work, method was developed to reproduce this alignment in electrospun scaffolds by varying geometry collecting mandrel. Elastomeric poly(ester urethane)urea onto rotating conical mandrels...
Surface modification can play a crucial role in enhancing cell adhesion to synthetic polymer-based scaffolds tissue engineering applications. Here, we report novel approach for layer-by-layer (LbL) fabrication of nanometer-size fibronectin and gelatin (FN-G) layers on electrospun fibrous poly(carbonate urethane)urea (PCUU) scaffolds. Alternate immersions into the solutions provided thickness-controlled FN-G nano-layers (PCUU(FN-G) ) which maintained scaffold's 3D structure width bundle PCUU...
Current extracellular matrix (ECM) derived scaffolds offer promising regenerative responses in many settings, however some applications there may be a desire for more robust and long lasting mechanical properties. A biohybrid composite material that offers both strength bioactivity optimal healing towards native tissue behavior solution to this problem. regionally distinct biocomposite scaffold composed of biodegradable elastomer (poly(ester urethane)urea) porcine dermal ECM gel was...
Non-invasively monitoring the mechanical property change of engineered tissue constructs in vivo may help evaluate and feedback scaffold design. In this paper, ultrasound elasticity imaging (UEI) was applied to detect changes implanted polyurethane on a rat abdominal defect. Bi-axial measurements excised tissue/scaffold were performed for comparison with UEI results. An increase overall stiffness along ingrowth observed 4 8weeks using both direct testing. While, pure embedded 10% gelatin...
Abstract A computational structural deterministic modeling strategy has been developed and experimentally validated to (1) assist tissue engineering scaffold fabrication, as a consequence improve in vivo scaffolds performances, (2) provide better understanding of cellular mechanical metabolic response local micro-structural deformations the extracellular matrix (ECM). Image analysis software was tested on electrospun poly (ester urethane) urea (PEUU) scaffolds, collagen gels, decellularized...
Abstract With our ability to incorporate viable cells distributed throughout the scaffold, we are provided a unique, controllable platform develop generalized finite deformation framework than can be used gain an understanding of how evolving extracellular matrix phase contributes construct gross mechanical behavior. The biosynthetic response microintegrated VSMC’s was investigated low (15%), intermediate (30%), and high (50%) strain groups. These magnitudes were chosen as they correspond...