A5019291793- Elasticity and Material Modeling
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Astrophysical Phenomena and Observations
- Electrospun Nanofibers in Biomedical Applications
- Orthopaedic implants and arthroplasty
- Rheology and Fluid Dynamics Studies
- Optical Systems and Laser Technology
- Galaxies: Formation, Evolution, Phenomena
- Gamma-ray bursts and supernovae
- Cardiac Structural Anomalies and Repair
- Tribology and Lubrication Engineering
- Aortic Disease and Treatment Approaches
- Advanced Measurement and Metrology Techniques
- Tissue Engineering and Regenerative Medicine
- Cardiomyopathy and Myosin Studies
- Mechanical Engineering and Vibrations Research
- Advanced X-ray Imaging Techniques
- Ocular Disorders and Treatments
- Retinal and Macular Surgery
- Composite Material Mechanics
- Cellular and Composite Structures
- Diabetic Foot Ulcer Assessment and Management
- Mechanics and Biomechanics Studies
Goddard Space Flight Center
2007-2024
University of Michigan
2020-2024
National Aeronautics and Space Administration
2024
The University of Texas at Austin
2014-2021
We present a broadband (∼0.5–79 keV) spectral and temporal analysis of multiple NuSTAR observations combined with archival Suzaku Chandra data NGC 4945, the brightest extragalactic source at 100 keV. observe hard X-ray (>10 flux variability, variations factor two on timescales 20 ks. A variable primary continuum dominates high-energy spectrum in all states, while reflected/scattered that E <10 keV stays approximately constant. From modeling complex reflection/transmission spectrum, we derive...
Understanding the biomechanics of heart in health and disease plays an important role diagnosis treatment failure. The use computational biomechanical models for therapy assessment is paving way personalized treatment, relies on accurate constitutive equations mapping strain to stress. Current state-of-the art account nonlinear anisotropic stress-strain response cardiac muscle using hyperelasticity theory. While providing a solid foundation understanding tissue, most current laws neglect...
The mitral valve (MV) is the left atrioventricular heart that regulates blood flow between atrium and ventricle (LV) during cardiac cycle. Contrary to aortic (AV), MV an intimately coupled, fully functional part of LV. In situations where fails close systole, resulting regurgitation into typically causes pulmonary congestion, leading failure and/or stroke. can be either primary (e.g., myxomatous degeneration) valvular tissue organically diseased, or secondary (typically induced by ischemic...
Abstract Biomechanical modeling has a wide range of applications in the medical field, including diagnosis, treatment planning and tissue engineering. The key to these predictive models are appropriate constitutive equations that can capture stress-strain response materials. While most rely on hyperelastic formulations, experimental evidence viscoelastic responses tissues new numerical techniques spurred development models. Classical as well fractional formulations have been proposed, but it...
Exogenous cross-linking of soft collagenous tissues is a common method for biomaterial development and medical therapies. To enable improved applications through computational methods, physically realistic constitutive models are required. Yet, despite decades research, clinical use, no such model exists. In this study, we develop the first rigorous full structural (i.e. explicitly incorporating various features collagen fibre architecture) exogenously cross-linked tissues. This was made...
Simulation of the mechanical behavior soft tissues is critical for many physiological and medical device applications. Accurate test data crucial both obtaining form robust parameter determination constitutive model. For incompressible that are either membranes or thin sections, planar biaxial testing configurations can provide much information about anisotropic stress-strain behavior. However, analysis biological tissue be complicated by in-plane shear, heterogeneities, inelastic changes in...
As the next step in our investigations into structural adaptations of main pulmonary artery (PA) during postnatal growth, we utilized extensive experimental measurements growing ovine PA from previous study (Fata et al., 2013, “Estimated vivo Postnatal Surface Growth Patterns Ovine Main Pulmonary Artery and Ascending Aorta,” J. Biomech. Eng., 135(7), pp. 71010–71012). to develop a constitutive model for wall tissue. Novel present approach was treatment elastin network as distributed fiber...
ABSTRACT Some reddened quasars appear to be transitional objects in the paradigm of merger-induced black hole growth/galaxy evolution, where a heavily obscured nucleus starts unveiled by powerful quasar winds evacuating surrounding cocoon dust and gas. Hard X-ray observations are able peer through this gas dust, revealing properties circumnuclear obscuration. Here, we present NuSTAR XMM-Newton / Chandra FIRST-2MASS-selected red F2M 0830+3759 1227+3214. We find that though is moderately ( N...