A5012328223- Venous Thromboembolism Diagnosis and Management
- Congenital Heart Disease Studies
- Blood Coagulation and Thrombosis Mechanisms
- Diagnosis and Treatment of Venous Diseases
- Protease and Inhibitor Mechanisms
- Transplantation: Methods and Outcomes
- Central Venous Catheters and Hemodialysis
- Congenital heart defects research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Anesthesia and Neurotoxicity Research
- Vascular anomalies and interventions
- Infective Endocarditis Diagnosis and Management
- Renal and Vascular Pathologies
- Cardiovascular and Diving-Related Complications
- Cardiac Fibrosis and Remodeling
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Disease and Adiposity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammation biomarkers and pathways
University of Michigan
2021-2024
University of Maryland, Baltimore
2018-2020
Adult Congenital Heart Association
2018
Clemson University
2015-2017
Hypoplastic left heart syndrome is a type of congenital disease characterized by underdevelopment the ventricle, outflow tract, and aorta. The condition fatal if aggressive palliative operations are not undertaken, but even after complete 3-staged surgical palliation, there significant morbidity because progressive ultimately intractable right ventricular failure. For this reason, interest in developing novel therapies for management dysfunction patients with hypoplastic syndrome. Stem cell...
Balloon venoplasty is a commonly used clinical technique to treat deep vein stenosis and occlusion as consequence of trauma, congenital anatomic abnormalities, acute thrombosis (DVT), or stenting. Chronic venous obstruction histopathologically characterized by thrombosis, fibrosis, both. Currently, no direct treatment available target these pathological processes. Therefore, reliable in vivo animal model test novel interventions necessary. The rodent survival inferior vena cava (IVC) balloon...
Balloon venoplasty is a commonly used clinical technique to treat deep vein stenosis and occlusion as consequence of trauma, congenital anatomic abnormalities, acute thrombosis (DVT), or stenting. Chronic venous obstruction histopathologically characterized by thrombosis, fibrosis, both. Currently, no direct treatment available target these pathological processes. Therefore, reliable in vivo animal model test novel interventions necessary. The rodent survival inferior vena cava (IVC) balloon...
Background: Loss of TLR4 signaling reduces Venous Thrombosis (VT) resolution. Leukocyte expression is elevated in humans undergoing acute to chronic DVT transformation. We hypothesized that monocytes directs thrombus clearance. Methods: Wild type, Tlr4 -/- , LysM cre+/- fl/fl mice underwent VT via IVC stasis at 4/7/14d timepoints. Thrombi subtypes were identified by flow cytometry. Thrombus size was assessed, and fibrinolytic mediators assayed splenic/bone marrow Mφs. Whole blood from...
Background: Deep venous stenting is a common strategy to treat deep vein thrombosis (DVT) decreasing future symptoms and complications. We propose histopathological characterization of stents deployed in the inferior vena cava rats demonstrate how it correlates with ultrasound evaluation. Methods: Sprague Dawley (643±62g) were anesthetized (isoflurane). IVC diameter was measured by on B mode. Through midline laparotomy, infrarenal side branches ligated, posterior cauterized, micro-clips...
Background: Endotheliitis in severe SARS-CoV-2 (CoV2) results increased cellular adhesion molecules (CAMs) and procoagulant (PCMs). Cell surface CAMs increase endothelial cell (EC) interactions with circulating immune cells (IC). Increased EC-IC a EC phenotype augment immunothrombotic risk during CoV2 infection. Prophylactic anticoagulants infection are associated unacceptably high bleeding risk. New targets to treat endotheliitis required. Hypothesis: We hypothesize chromatin modifying...
Plasminogen activator inhibitor-1 (PAI-1) is a multifunctional enzyme that inhibits fibrinolysis and modulates tissue fibrosis. Two domains of PAI-1 drive these processes: an antiprotease (P) domain plasmin generation consequently matrix metalloprotease (MMP) activation, vitronectin (V) binding interferes with inflammatory cell adhesion. To determine the relative importance each in venous fibrosis, we induced thrombosis CRISPR-Cas9 genetically modified mice point mutations respective (V+P−,...
Objectives Considerable growth of individual lung transplant programs remains challenging. We hypothesized that the systematic implementation modular risk components to a transplantation program would allow for expeditious without increasing mortality. Methods All consecutive patients placed on waitlist were reviewed. Patients stratified by an 18-month period surrounding Era 1 (1/2014-6/2015) and 2 (7/2015-12/2016). Modular separately evaluated donors, recipients, perioperative features....
Introduction: Postoperative tissue edema Norwood procedures contributes significantly to outcomes. As nicardipine preserves ventricular function after hypothermic ischemic arrest, treatment could support post-Norwood function, and decrease improve patient Methods: All completed at a single institute between 1/1/2012 - 12/31/2019 were retrospectively reviewed, the use of during rewarming was initiated midway through study period. We investigated effects on 12-month postoperative mortality,...