A5023091619- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Central Venous Catheters and Hemodialysis
- Vascular anomalies and interventions
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cell Adhesion Molecules Research
- Diabetic Foot Ulcer Assessment and Management
- Peripheral Artery Disease Management
- Inflammation biomarkers and pathways
- Consumer Attitudes and Food Labeling
- COVID-19 and healthcare impacts
- Cardiac Arrhythmias and Treatments
- Protease and Inhibitor Mechanisms
- Aortic aneurysm repair treatments
- Pregnancy and preeclampsia studies
- Medical and Biological Sciences
- Sports injuries and prevention
- Trauma and Emergency Care Studies
- Ultrasound in Clinical Applications
- Food composition and properties
- Cardiac Fibrosis and Remodeling
- S100 Proteins and Annexins
University of Michigan
2023-2025
Michigan Medicine
2025
Fundación Santa Fe de Bogotá
2022-2023
Universidad de Los Andes
2021-2023
Universidad del Norte
2023
Universidad de Los Andes
2022
Indiana University School of Medicine
2011
Indiana University – Purdue University Indianapolis
2009-2011
Background: Interventional therapies to relieve chronic deep vein thrombosis (DVT) fail through inability penetrate, cross, and remove the occlusion. Development of suitable tools requires fundamental understanding DVT mechanical properties a reliable model for testing. Methods: Female farm swine underwent novel, endovenous generation long-segment unilateral iliac thrombosis. Thrombus was confirmed via venogram, intravascular ultrasound, transabdominal duplex 14 days. components were...
Endothelial colony-forming cells (ECFCs) isolated from umbilical cord blood (CBECFCs) are highly proliferative and form vessels in vivo. The purpose of this investigation was to isolate characterize a population resident ECFCs the chorionic villi term human placenta provide comparative analysis their vasculogenic potential with CBECFCs. were placentas obtained by caesarean deliveries. Placental (PECFCs) expressed CD144, CD31, CD105, KDR negative for CD45 CD34, consistent other ECFC...
Among the worldwide recognized innovators that contributed to development of inferior vena cava (IVC) filter prototypes in 1960s by Kazi Mobbin-Uddin (1967; umbrella IVC filter) and Lazar J. Greenfield (1973; cone-shaped filter), earlier open surgical techniques including sutures Marion DeWeese (1958; grid-harp with silk sutures), external devices as clips James A. T. (1965; Adams-DeWeese clip),1Galanaud J.P. Laroche Righini M. The history historical treatments deep vein thrombosis.J Thromb...
Background Superficial vein aneurysms (SVA) are rare vascular pathologies associated with trauma, chronic venous disease, and malformation. Method We retrospectively reviewed cases of SVA treated from 1986 to 2022. Results Out 2463 procedures, 16 patients were found 19 GSV 1 SSV aneurysms, 88% presenting a palpable mass. Varicose veins noted in 94% patients, 81% had concomitant reflux, 15% thrombus within the aneurysm sac, 19% demonstrated multiple aneurysms. All underwent ligation excision....
Balloon venoplasty is a commonly used clinical technique to treat deep vein stenosis and occlusion as consequence of trauma, congenital anatomic abnormalities, acute thrombosis (DVT), or stenting. Chronic venous obstruction histopathologically characterized by thrombosis, fibrosis, both. Currently, no direct treatment available target these pathological processes. Therefore, reliable in vivo animal model test novel interventions necessary. The rodent survival inferior vena cava (IVC) balloon...
Balloon venoplasty is a commonly used clinical technique to treat deep vein stenosis and occlusion as consequence of trauma, congenital anatomic abnormalities, acute thrombosis (DVT), or stenting. Chronic venous obstruction histopathologically characterized by thrombosis, fibrosis, both. Currently, no direct treatment available target these pathological processes. Therefore, reliable in vivo animal model test novel interventions necessary. The rodent survival inferior vena cava (IVC) balloon...
La siguiente revisión histórica resalta personajes ilustres que contribuyeron -no solamente con un aporte a la medicina- sino cambios de pensamiento llevaron floreciera cirugía, y por ellos hoy en día contamos diferentes paradigmas quirúrgicos médicos cirugía moderna. Presentamos resumen 22 epónimos, sus vidas, aportes datos curiosos desde 1577 hasta modernidad, buscan inspirar las generaciones cirujanos formación. Esta subdivide los epónimos incluidos tres momentos históricos: europa...
Background: Loss of TLR4 signaling reduces Venous Thrombosis (VT) resolution. Leukocyte expression is elevated in humans undergoing acute to chronic DVT transformation. We hypothesized that monocytes directs thrombus clearance. Methods: Wild type, Tlr4 -/- , LysM cre+/- fl/fl mice underwent VT via IVC stasis at 4/7/14d timepoints. Thrombi subtypes were identified by flow cytometry. Thrombus size was assessed, and fibrinolytic mediators assayed splenic/bone marrow Mφs. Whole blood from...
Background: Deep venous stenting is a common strategy to treat deep vein thrombosis (DVT) decreasing future symptoms and complications. We propose histopathological characterization of stents deployed in the inferior vena cava rats demonstrate how it correlates with ultrasound evaluation. Methods: Sprague Dawley (643±62g) were anesthetized (isoflurane). IVC diameter was measured by on B mode. Through midline laparotomy, infrarenal side branches ligated, posterior cauterized, micro-clips...
Background: Endotheliitis in severe SARS-CoV-2 (CoV2) results increased cellular adhesion molecules (CAMs) and procoagulant (PCMs). Cell surface CAMs increase endothelial cell (EC) interactions with circulating immune cells (IC). Increased EC-IC a EC phenotype augment immunothrombotic risk during CoV2 infection. Prophylactic anticoagulants infection are associated unacceptably high bleeding risk. New targets to treat endotheliitis required. Hypothesis: We hypothesize chromatin modifying...
BACKGROUND: Telangiectasias are dilated blood vessels on the skin that develop progressively because of several diseases, including chronic venous disease. The flow has differences compared to rest circulatory system. These have a permanent vasoconstrictor tone can respond vasoconstriction/vasodilation stimulative substances and higher or lower temperatures. aim this study was investigate any possible telangiectasias vasoconstriction vasodilation in response temperature changes.METHODS: This...
BACKGROUND: Foam sclerotherapy is a minimally invasive technique to treat chronic venous insufficiency. stability influences the effectiveness of treatment, determining degree endothelial injury induced by sclerosant. Unstable foam will require higher concentrations sclerosant achieve same effect compared more stable foam, increasing probability adverse events. Several variables have been studied determine stability; however, little known about impact altitude. This study aims evaluate...
Purpose This study aims to facilitate access vascular disease screening for low-income individuals living in remote and conflict areas based on the results of a pilot trial Colombia. Also, increase amount diagnosis training surgery (VS) civilians. Design/methodology/approach The operation method includes five stages: strategy development adjustment; translation into real-world setting; logistics planning; analysis adoption. plan worked efficiently this study’s sample. It demonstrated high...
Background: Chronic deep venous occlusions, leading to outflow obstruction in dialysis patients and post thrombotic syndrome (PTS) DVT patients, are often treated with balloon venoplasty stenting restore flow improve limb outcomes. In stent restenosis occlusion primary reasons for late intervention failure. mTOR inhibitors might impact fibrotic pathways on endothelial cells (VEC). Methods: Immortalized murine VEC (EOMA, ATTC #CRL-2586) were stimulated sirolimus (1ng) vehicle (DMSO)...
Background: Leukocyte expression of Toll-like receptor 4 (TLR4) increases with transformation to chronic deep venous thrombosis (DVT) & in non-resolving thrombi, but TLR4 function during thrombus clearance is unclear. We hypothesized signaling regulate fibrinolytic factors monocytes macrophages (MO/MFs) for VT resolution. Methods: Small interfering RNA (siRNA) knockdown (KD) disruption Myd88-dependent/independent pathways occurred immortalized MFs (RAW264.7), quantitative real-time PCR...