Expanding the useful lifespan of materials is becoming highly desirable, and self-healing self-repairing may become valuable commodities. The formation supramolecular through host–guest interactions a powerful method to create non-conventional materials. Here we report hydrogels their redox-responsive properties due interactions. We employ cyclodextrin (CD) as host molecule because it environmentally benign has diverse applications. A transparent hydrogel quickly forms upon mixing...

ConspectusCyclodextrins (CDs) have many attractive functions, including molecular recognition, hydrolysis, catalysis, and polymerization. One of the most important uses CDs is for recognition hydrophobic organic guest molecules in aqueous solutions. are desirable host because they environmentally benign offer diverse functions.This Account demonstrates some great advances development supramolecular materials through host–guest interactions within last 10 years. In 1990, we developed...

The development of stimulus-responsive polymeric materials is great importance, especially for the remotely manipulated not in direct contact with an actuator. Here we design a photoresponsive supramolecular actuator by integrating host–guest interactions and photoswitching ability hydrogel. A hydrogel α-cyclodextrin as host molecule azobenzene derivative guest exhibits reversible macroscopic deformations both size shape when irradiated ultraviolet light at 365 nm or visible 430 nm....

Supramolecular hydrogels formed by a host-guest interaction show self-healing properties. The cube-shaped with β-cyclodextrin and adamantane guest molecules mend after being broken. sufficiently heal to form single gel, the initial strength is restored. Although contact between freshly cut uncut surface does not gels, two surfaces selectively mend. As service our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may be...

Abstract Supramolecular materials cross‐linked between polymer chains by noncovalent bonds have the potential to provide dynamic functions that are not produced covalently polymeric materials. We focused on formation of supramolecular through host–guest interactions: a powerful method for creation nonconventional employed two different kinds inclusion complexes β‐cyclodextrin (βCD) with adamantane (Ad) and ferrocene (Fc) bind polymers together form hydrogel (βCD‐Ad‐Fc gel). The βCD‐Ad‐Fc gel...

Flexible, tough, and self‐healable polymeric materials are promising to be a solution the energy problem by substituting for conventional heavy materials. A fusion of supramolecular chemistry polymer is powerful method create such intelligent Here, material using multipoint molecular recognition between cyclodextrin (CD) hydrophobic guest molecules at side chain reported. transparent, flexible, tough hydrogel (host–guest gel) formed simple preparation procedure. The host–guest gel shows...

Ein supramolekulares Hydrogel entsteht aus einem wasserlöslichen Polymer, das über Wirt-Gast-Einschlusskomplexe zwischen Cyclodextrin und Ferrocen vernetzt ist. Die Dissoziation Neubildung von Einschlusskomplexen durch Redoxstimuli führte zur makroskaligen Ausdehnung Kontraktion des Hydrogels. Das Gel wird als redoxaktiver Aktuator verwendet, die mechanische Arbeit konnte ermittelt werden.

Abstract The macroscopic self‐assembly of polymeric hydrogels modified with β‐cyclodextrin (βCD gel), ferrocene (Fc and styrenesulfonic acid sodium salt (SSNa gel) was investigated. Under reductive conditions, the Fc gel selectively adhered to βCD through a host–guest interaction. On other hand, oxidized ferrocenium + ) SSNa an ionic interaction under oxidative conditions. adhesion strength estimated by tensile test. We finally succeeded in forming ABC‐type assembly all three gels two...

The visualization of changes in the stress and bonding state inside polymeric materials is an attractive function science. In this study, phenolphthalein (PP) was selected to prepare stimuli-responsive coloring materials. PP becomes purple under basic conditions aqueous solutions; however, colorless when it forms a complex with β-cyclodextrin (βCD). To exploit property PP, we prepared color-changing hydrogel (βCD-PP AAm hydrogel) based on acrylamide (AAm) as main chain βCD moieties side...

Many essential cellular processes are regulated by mechanical properties of their microenvironment. Here, we introduce stimuli-responsive composite scaffolds fabricated three-dimensional (3D) laser lithography to simultaneously stretch large numbers single cells in tailored 3D microenvironments. The key material is a photoresist containing cross-links formed noncovalent, directional interactions between β-cyclodextrin (host) and adamantane (guest). This allows reversible actuation under...

Abstract Ample evidence has demonstrated that biological cells not only react to biochemical cues from the surrounding microenvironments but also sensitively detect mechanical properties of extracellular matrix and neighboring adapt their shape, function, fate. Mechanical aspects in biology, called mechanobiology, have been attracting biologists, chemists, physicists, engineers. However, most vitro studies date heavily relied on covalently cross-linked hydrogels with prefixed hence...

The interaction between poly(acrylamide) gels carrying phenylboronic acid (PB gel) and catechol moieties (CAT respectively is investigated. PB gel forms an assembly with the CAT on a macroscopic scale in basic aqueous media. adhesion strength estimated by stress-strain measurements. disassembly of are reversibly switched varying pH medium. tunable competitive monosaccharide molecules accordance association constant moieties.

Functional polymeric materials constructed by noncovalent bonds have attracted considerable attention due to their beneficial stretching and self-healing properties. We chose host–guest interactions using cyclodextrins (CDs) as host molecules realize supramolecular with Notably, an inclusion complex of a CD guest molecule functions reversible bond in material. Herein, we studied the relationship between mechanical properties based on association constants CDs molecular structures molecules....

Supramolecular materials based on host–guest interactions should exhibit high selectivity and external stimuli‐responsiveness. Among various stimuli, redox photo stimuli are useful for its wide application. An stimuli‐responsive adhesive system between CD host‐gels (CD gels) guest molecules modified glass substrates (guest Sub) is focused. Here, the selective adhesion host gels where depends molecular complementarity reported. Initially, it thought that of a gel material onto hard might be...

Visible light-induced hydrogelation is attractive for various biomedical applications. In this study, hydrogels of alginate with phenolic hydroxyl groups (Alg-Ph) were obtained by irradiating a solution containing the polymer, ruthenium II trisbipyridyl chloride ([Ru(bpy)3]2+) and sodium persulfate (SPS), visible light. The kinetics mechanical properties resultant tunable controlling intensity light concentrations [Ru(bpy)3]2+ SPS. With appropriate SPS, hydrogel could be following...

A new class of supramolecular hydrogels, cross-linked by host-guest interactions between β-cyclodextrin (βCD) and adamantane, were designed for the dynamic regulation cell-substrate interactions. The initial substrate elasticity can be optimized selecting molar fraction host- guest monomers target cells. Moreover, owing to reversible nature interactions, magnitude softening stiffening modulated varying concentrations free, competing host molecules in solutions. By changing at a desired time...

Hydrogels were prepared by contacting air containing 10–50 ppm H2O2 with an aqueous solution polymer(s) possessing phenolic hydroxyl (Ph) moieties (polymer-Ph) and horseradish peroxidase (HRP). In this system, HRP catalyzes cross-linking of the Ph consuming diffused from air. The hydrogelation rate mechanical properties resultant hydrogels can be tuned controlling concentration in air, exposure time to polymer-Phs HRP, concentration. shortest stirred 16 was 6 s. Based on these findings,...

Abstract Supramolecular materials cross‐linked between polymer chains by noncovalent bonds have the potential to provide dynamic functions that are not produced covalently polymeric materials. We focused on formation of supramolecular through host–guest interactions: a powerful method for creation nonconventional employed two different kinds inclusion complexes β‐cyclodextrin (βCD) with adamantane (Ad) and ferrocene (Fc) bind polymers together form hydrogel (βCD‐Ad‐Fc gel). The βCD‐Ad‐Fc gel...

Abstract Access to clean water, hygiene, and sanitation is becoming an increasingly pressing global demand, particularly owing rapid population growth urbanization. Phytoremediation utilizes a highly conserved phytochelatin in plants, which captures hazardous heavy metal ions from aquatic environments sequesters them vacuoles. Herein, we report the design of phytochelatin-inspired copolymers containing carboxylate thiolate moieties. Titration calorimetry results indicate that coexistence...

Anion recognition in water by synthetic host molecules is a popular and challenging topic. It has been considered difficult because the compete for units. In this study, we have successfully created novel macrocycle that achieves precise through multipoint hydrogen bonding harmony with molecules. Specifically, an

Supramolecular polymeric materials have received much attention in recent years due to the fabrication of supramolecular with mechanical properties and stimuli-responsive response designs based on noncovalent cross-linkers. Host–guest interactions are useful that can be employed realize materials. To understand relationship between host–guest molecular structure guest molecules polymer side chain, we prepared hydrogels cross-linked by inclusion complexes cyclodextrin (CD) cationic alkyl...

We report an extrusion-based bioprinting approach, in which stabilization of extruded bioink is achieved through horseradish peroxidase (HRP)-catalyzed cross-linking consuming hydrogen peroxide (H

The cell cycle is known to be regulated by features such as the mechanical properties of surrounding environment and interaction cells with adhering substrates. Here, we investigated possibility regulating cell-cycle progression on gelatin/hyaluronic acid composite hydrogels obtained through hydrogen peroxide (H2O2)-mediated cross-linking degradation polymers varying exposure time H2O2 contained in air. stiffness hydrogel varied time. Human cervical cancer (HeLa) mouse mammary gland...