A5033734292- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Reproductive tract infections research
- Diagnosis and treatment of tuberculosis
- Leptospirosis research and findings
- Genomics and Phylogenetic Studies
- Urinary Tract Infections Management
- Antibiotic Resistance in Bacteria
- Plant and fungal interactions
- Veterinary medicine and infectious diseases
- Viral Infections and Vectors
- Biomedical Text Mining and Ontologies
- Blood groups and transfusion
- Adolescent Sexual and Reproductive Health
- Cervical Cancer and HPV Research
- Infectious Diseases and Tuberculosis
- Bacteriophages and microbial interactions
- Natural Language Processing Techniques
National Science and Technology Development Agency
2015-2023
National Center for Genetic Engineering and Biotechnology
2002-2023
Oregon State University
2002
Abstract Global Mycobacterium tuberculosis population comprises 7 major lineages. The Beijing strains, particularly the ones classified as Modern groups, have been found worldwide, frequently associated with drug resistance, younger ages, outbreaks and appear to be expanding. Here, we report analysis of whole genome sequences 1170 M . isolates together their patient profiles. Our samples belonged Lineage 1–4 (L1–L4) those L1 L2 being equally dominant. Phylogenetic revealed several new or...
Tuberculosis presents a global health challenge. Mycobacterium tuberculosis is divided into several lineages, each with different geographical distribution. M. lineage 1 (L1) common in the high-burden areas East Africa and Southeast Asia. Although founder effect contributes significantly to phylogeographic profile, co-evolution between host may also play role. Here, we reported genomic analysis of 480 L1 isolates from patients northern Thailand. The studied bacterial population was...
Homoplastic mutations are independently occurring in different clades of an organism. The homoplastic changes may be a result convergence evolution due to selective pressures. Reports on the analysis Mycobacterium tuberculosis have been limited. Here we characterized distribution single nucleotide polymorphisms (SNPs) among genomes 1,170 clinical M. isolates. They were present all functional categories genes, with pe/ppe gene family having highest ratio SNPs compared total identified same...
In bacterial pathogens, both cell surface-exposed outer membrane proteins and secreted into the extracellular environment play crucial roles in host-pathogen interaction pathogenesis. Considerable efforts have been made to identify (OM) (EX) produced by Leptospira interrogans, which may be used as novel targets for development of infection markers leptospirosis vaccines. this study we a computational framework based on combined prediction methods with deduction concept putative OM EX encoded...
The obligately intracellular chlamydiae are bacterial pathogens that occupy vacuoles, termed inclusions, as they develop and multiply. Typical Chlamydia trachomatis isolates inclusions fuse with other C. within cells infected multiple elementary bodies (wild-type phenotype). authors of this study have recently described form multiply-lobed, non-fusogenic single (variant Inclusions formed by these uniformly lacked the protein IncA on inclusion membrane (IM). In present work, phenotype has...
Mutations in genes involved drug metabolism have been well-associated with resistance. Sequence analysis of known antimycobacterial drug-resistant is often used to predict resistance antibiotics. However, some polymorphisms such may serve a phylogenetic purpose rather than drugs. The Beijing family Mycobacterium tuberculosis (MTB) prevalent worldwide and has associated the emergence multidrug type (ST) 10 most predominant countries like Peru, Taiwan Thailand. A sequence was performed 81...
We present the draft genome sequence of Mycobacterium tuberculosis strain 43-16836, belonging to Indo-Oceanic lineage, isolated from a tuberculous meningitis patient in Thailand. The is 4,381,942 bp long with 4,316 protein-coding genes and contains new single nucleotide polymorphisms (SNPs), including SNPs that may encode cell wall components possibly influence virulence.
Chlamydia pneumoniae causes human respiratory diseases and has recently been associated with atherosclerosis. Analysis of the three published C. genomes led to identification a new gene family (the Cpn 1054 family) that consists 11 predicted genes fragments. Each member encodes polypeptide hydrophobic domain characteristic proteins localized inclusion membrane. Comparative analysis this within genome sequences provided evidence multiple levels genetic variation are evident single collection...