Anemia in astronauts has been noted since the first space missions, but mechanisms contributing to anemia flight have remained unclear. Here, we show that is associated with persistently increased levels of products hemoglobin degradation, carbon monoxide alveolar air and iron serum, 14 throughout their 6-month missions onboard International Space Station. One year after landing, erythrocytic effects persisted, including hemolysis, reticulocytosis hemoglobin. These findings suggest...

Background: The most widely used surgical approach to treat radial head fractures is through the Kocher interval. However, extensor digitorum communis (EDC) splitting thought allow easier access anterior half of head, which more commonly fractured. aim this cadaveric study was compare osseous and articular surface areas visible EDC split Methods: Four approaches were in fresh frozen upper extremities: (n = 6), modified extended 4). For each approach, visualized outlined with use a burr. Each...

Aim Several clinical studies have shown that lateral pinning alone is of equal stability to crossed pins in the treatment supracondylar fractures. The aim this study was compare parallel and varied divergent pin configurations provide an easily reproducible technique for optimal placement. Methods Twelve third-generation synthetic composite humeri were osteotomized at level coronoid olecranon fossae simulate a humeral fracture. Each fracture reduced fixed using two 1.6 mm (0.062 inches)...

This study aimed to measure hemolysis before, during and after 60 days of the ground-based spaceflight analog bed rest effect a nutritional intervention through prospective randomized clinical trial. Twenty male participants were hospitalized for 88 comprised 14 ambulatory baseline, 6° head-down tilt reambulation. Ten each received control diet or daily polyphenol associated with omega-3, vitamin E, selenium supplements. The primary outcome was endogenous carbon monoxide (CO) elimination...

Abstract Modularity in total hip replacement offers advantages with regard to biomechanical adjustments and leg lengths. Recently, modular femoral necks were introduced as an added advantage head modularity permitting further version well offset ease of revision. Currently, most are made Ti6Al4V for which cases vivo fractures inseparable neck‐stem junctions have been reported. Therefore, we investigated CoCrMo head–Ti6Al4V stem replacements alternative Ti6Al4V. We compared the two materials...

Hip implant neck fractures and adverse tissue reactions associated with fretting-corrosion damage at modular interfaces are a major source of concern. Therefore, there is an urgent clinical need to develop accurate in vitro test procedures better understand, predict prevent vivo failures. This study aimed simulate fatigue fracture distraction necks setting, assess the effects material (Ti6Al4V vs. CoCrMo) assembly method (hand impact) on life necks. Fatigue tests were performed cementless...

To examine the stability of plate (locking and non-) versus screw constructs in fixation these fractures.An anteromedial coronoid facet fracture (OTA/AO type 21-B1, O'Driscoll 2, subtype 3) was simulated 24 synthetic ulna bones that were then assigned to 3 groups: non-locking plate, locking (LP), or fixation. Each construct first cycled tension (through a medial collateral ligament) compression. They loaded failure (displacement >2 mm). Fracture fragment displacement recorded with an optical...

Abstract We investigated a commercial Co–Cr‐alloy head—Ti6Al4V alloy neck and Ti6Al4V stem modular total hip replacement. assessed the distraction forces after in vitro cycling bovine serum, fatigue durability, fretting corrosion damage, load bearing capacity of new implants using fatigue‐corrosion, pull‐off, scanning electron microscopy, compression investigations. In addition, we studied corrosion, on retrievals. For both retrievals test samples, neck–stem interface required higher force...

BackgroundThe introduction of highly cross-linked polyethylene (HXLPE) acetabular liners has greatly improved the wear performance metal-on-PE bearing surfaces used in total hip arthroplasty. Changing sterilization environment and adding thermal treatments, such as remelting or annealing, were introduced to limit on-shelf vivo oxidation liners. This study compares properties remelted A-CLASS (MicroPort) HXLPE liner a sequentially annealed HXLPE.MethodsThis retrospective assessed linear...

Berdusco, Randa MD, FRCSC; Louati, Hakim MASc; Desloges, William Papp, Steven R. MSc, Pollock, J Whitcomb FRCSC Author Information

There have been no studies assessing the optimal biomechanical tension of suture button constructs. The purpose this study was to assess tensioning fixation and its ability maintain reduction under loaded conditions using a stress computed tomography (CT) model.Ten cadaveric lower limbs disarticulated at knee were used. placed in modified ankle load frame that allowed for application sustained torsional axial or combined torsional/axial loads. syndesmosis deep deltoid ligaments complex...

Arthroscopic rotator cuff repairs are mostly secured with suture anchors and often supplemented by footprint decortication. The objectives of this study were to characterize the strength bone–tendon healing following anchor repair assess effect channeling supraspinatus (SSP) humeral 1 week ahead reattachment surgery. One hundred twelve rabbits underwent unilateral detachment one SSP tendon randomly assigned two groups: at time no channeling. later, was performed using an anchor. repaired...

Background: Coronal shear fractures of the distal aspect humerus that involve capitellum and trochlea are rare; nevertheless, they difficult to treat because complex fracture patterns osteochondral nature fragments, limiting optimal screw placement. The use anterior-to-posterior fixation by a lag technique (without countersinking) could potentially improve strength construct. Our primary research question was anatomically determine if there is non-articulating zone for placement along...

Purpose To image the supraspinatus enthesis reformation of rabbit shoulders by magnetic resonance at 7 Tesla (T) using T2 mapping after surgical repair and to assess effects channeling aimed enhancing reformation. Materials Methods In 112 rabbits, distal (SSP) tendon was unilaterally detached reattached 1 week. At first surgery, performed footprint in 64 rabbits. second SSP all rabbits re‐attached greater tuberosity. The were harvested 0, 1, 2, or 4 weeks surgery imaged 7T. Quantitative...

Posterior malleolus (PM) fractures are common in rotational ankle injuries, tibial plafond fractures, and distal third tibia fractures. Surgical indications continue to evolve as we improve our understanding of syndesmotic stability. These remain technically challenging with respect both exposure fixation. Our biomechanical cadaveric study compared posterolateral versus modified posteromedial surgical approaches define the following: maximal surface area exposed, screw trajectory obtainable...

The deltopectoral approach is commonly used in shoulder arthroplasty. Various soft tissue releases can be performed to obtain adequate glenoid exposure, but their effectiveness not known. purpose of this study was (1) quantify the effects various on amount surface area exposure and (2) determine if common about significantly improve glenoid.A standard cadaveric shoulders (n=8) beach chair position. were as follows: long head biceps, pectoralis major tendon, inferior capsule, posterior...

Abstract Background Supraspinatus (SSP) tendon ruptures requiring surgical repair are common. Arthroscopic suture anchor fixation has gradually replaced transosseous in supraspinatus tear. Our objective was to compare mechanical properties between and the first 6 postoperative weeks a rabbit model. Methods One hundred fifty-two rabbits had one repaired either with an 1 week after detachment or sutures. Rabbits were euthanized at 0, 1, 2, 4 weeks. Experimental contralateral tendons (304...

Rotator cuff anchor repair is an increasingly common surgical procedure but the failure rate remains high. In order to improve outcomes, a better understanding of postrepair histological and cellular responses at tendon-bone attachment site (enthesis) needed. We examined operated shoulders from 42 New Zealand female white rabbits. The animals underwent unilateral supraspinatus detachment followed by week later. To assess enthesis reformation, fibrocartilage staining area number chondrocytes...

Early femoral component migration is a useful indicator for identifying implants at risk of failure due to aseptic loosening. The goal this retrospective study was identify if anterior approach (AA) treated hips are higher loosening caused by early compared operated on using the traditional posterior (PA).A total 388 were included in study, 139 AA and 249 PA hips. Femoral evaluated EBRA-FCA radiographs assessed radiolucency latest follow-up. Preoperative 2-year clinical outcomes reported.The...

The quantitative assessment of supraspinatus tendons by conventional magnetic resonance is limited low contrast-to-noise ratio (CNR). Magnetic imaging (MRI) scanners operating at 7 Tesla offer high signal-to noise (SNR), CNR and spatial resolution that are well-suited for rapidly relaxing tissues like tendons. Few studies have applied T2 T2* mapping to musculoskeletal the rotator cuff Our objective was analyze relaxation times from surgically repaired effect bone channeling.One tendon 112...