A5005482837- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Chronic Lymphocytic Leukemia Research
- Neuroendocrine Tumor Research Advances
- Vaccine Coverage and Hesitancy
- Cancer Genomics and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Metabolomics and Mass Spectrometry Studies
- Colorectal Cancer Treatments and Studies
- Economic and Financial Impacts of Cancer
- Monoclonal and Polyclonal Antibodies Research
- Brain Metastases and Treatment
- COVID-19 Impact on Reproduction
- Global Cancer Incidence and Screening
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- COVID-19 epidemiological studies
- Lung Cancer Treatments and Mutations
- Cervical Cancer and HPV Research
- Advances in Oncology and Radiotherapy
- Esophageal Cancer Research and Treatment
Monash Health
2022-2024
Monash Medical Centre
2021-2024
Monash University
2020-2024
Whitstable and Tankerton Hospital
2024
Hospital of Prato
2017-2023
Hudson Institute
2022
Australian Regenerative Medicine Institute
2022
International Breast Cancer Study Group
2021
Azienda Usl Toscana Centro
2020
Nuovo Ospedale di Prato
2019-2020
The activity of palbociclib as a single agent in advanced breast cancer has not been extensively studied, with the only available clinical data limited to heavily pretreated patients. Preclinical suggests may partially reverse endocrine resistance, though this hypothesis evaluated previous studies. This phase II, open-label, multicenter study examined monotherapy, well given combination same therapy (ET) that was received prior disease progression, postmenopausal women moderately pretreated,...
In the treatment of advanced non-small cell lung cancer (NSCLC), immune checkpoint inhibitors have shown remarkable results. However, not all patients with NSCLC respond to this drug or receive durable benefits. Thus, patient stratification and selection, as well identification predictive biomarkers, represent pivotal aspects address. framework, metabolomics can be used support discrimination between responders non-responders. Here, was analyze sera samples from 50 NSCL treated inhibitors....
People with cancer are at higher risk of serious illness and death from COVID-19 infection. We investigated vaccine uptake among patients solid organ blood cancers explored factors related to hesitancy.Cross-sectional online survey adults a history three health services across metropolitan regional Victoria. Vaccine hesitancy was measured by the validated Oxford scale.There were 1073 respondents: 56% female; median age 62 years (range 23 - 91). Commonest tumor types included breast 29%,...
Thymidine kinase 1 (TK1) is downstream to the CDK4/6 pathway, and TK activity (TKa) measured in blood a dynamic marker of outcome patients with advanced breast cancer (ABC). This study explores TK1 as biomarker palbociclib response, both vitro ABC.Modulation levels by were studied seven estrogen receptor-positive cell lines: sensitive (PDS) acquired resistance (PDR). TKa was assayed plasma obtained at baseline (T0), after one cycle (T1), disease progression on (T2) enrolled "To Reverse...
As COVID-19 vaccinations became available and were proven effective in preventing serious infection, uptake amongst individuals varied, including medically vulnerable populations. This cross-sectional multi-site study examined vaccine uptake, hesitancy, explanatory factors people with and/or chronic health conditions, the impact of underlying disease on attitudes to vaccination. A 42-item survey was distributed cancer, diabetes, or multiple sclerosis across ten Australian services from 30...
Circulating tumor cells (CTCs) are prognostic in patients with advanced breast cancer (ABC). However, no data exist about their use treated palbociclib. We analyzed the role of CTC counts enrolled cTREnd study, a pre-planned translational sub-study TREnd (NCT02549430), that randomized ABC to palbociclib alone or plus endocrine therapy received prior line treatment. Moreover, we evaluated RB1 gene expression on CTCs and explored its within subpopulation. Forty-six ER-positive, HER2-negative...
1038 Background: ARX788 is a site-specific, homogeneous, and highly stable ADC. The payload AS269 conjugated to the synthetic amino acids para-acetylphenylalanine (pAF) in humanized anti-HER2 mAb. demonstrated promising activity HER2-positive, HER2-low, T-DM1 resistant tumors preclinical studies. Here we present phase 1 clinical data evaluating safety, antitumor activity, PK of advanced solid tumors. Methods: standard 3+3 design (0.33 - 1.5 mg/kg; Q3W or Q4W) used determine MTD and/or RP2D...
Currently, there is limited data regarding the effectiveness of standard subsequent line therapies such as endocrine therapy, chemotherapy, or targeted agents after progression on CDK4/6 inhibitor-based regimens. This paper describes time-to-treatment failure beyond palbociclib palbociclib+endocrine therapy in patients enrolled phase II, multicenter TREnd trial. Our results indicate that benefit from post-palbociclib treatment, regardless type received. A small population long responders...
Adjuvant treatment for patients with early stage colorectal cancer (eCRC) is currently based on suboptimal risk stratification, especially elderly patients. Metabolomics may improve the identification of residual micrometastases after surgery. In this retrospective study, we hypothesized that metabolomic fingerprinting could stratification in eCRC. Serum samples obtained surgery from 94 eCRC (65 relapse free and 29 relapsed, 5-years median follow up), 75 metastatic (mCRC) before a new line...
Abstract Despite recent refinements to the 21-gene g score, allowing a better identification of patients who may derive no benefit from addition adjuvant chemotherapy that endocrine therapy, with early breast cancer still stand be over-treated in setting clinical and/or genomic uncertainty or discordance. Here we describe and demonstrate potential approach further refining OncotypeDX risk score by metabolomic analysis serum. In dataset ( N = 87), recurrence was sub-stratified signature, an...
Vaccination is the cornerstone of global public health response to COVID-19 pandemic. Excess morbidity and mortality infection seen in people with cancer. vaccine hesitancy has been observed this medically vulnerable population, although associated attitudes beliefs remain poorly understood.An online cross-sectional survey solid organ cancers was conducted through nine services across Australia. Demographics, cancer-related characteristics uptake were collected. Perceptions regarding...