A5090239814- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Polymer Synthesis and Characterization
- Polymer Surface Interaction Studies
- Surfactants and Colloidal Systems
- Chromatography in Natural Products
- biodegradable polymer synthesis and properties
- Polymer crystallization and properties
- Dendrimers and Hyperbranched Polymers
- Protein purification and stability
- Mass Spectrometry Techniques and Applications
- Polymer composites and self-healing
- Analytical chemistry methods development
- Polymer Nanocomposites and Properties
- Adsorption, diffusion, and thermodynamic properties of materials
- Electrostatics and Colloid Interactions
- Advanced Thermodynamics and Statistical Mechanics
- Phase Equilibria and Thermodynamics
- Diffusion Coefficients in Liquids
- Analytical Chemistry and Sensors
- Pickering emulsions and particle stabilization
- Synthesis and properties of polymers
- Proteins in Food Systems
- Nanoparticle-Based Drug Delivery
- Spectroscopy and Chemometric Analyses
Czech Academy of Sciences, Institute of Macromolecular Chemistry
2012-2021
Czech Academy of Sciences
1993-2013
McGill University
2012
A new drug-delivery system of polymer nanoparticles (NPs) bearing pinacol-type boronic ester and alkyne moieties displaying triggered self-immolative degradation in the presence reactive oxygen species (ROS) with capability cellular imaging is presented. The NPs specifically release their drug cargo under concentrations ROS that are commonly found intracellular environment certain tumors inflamed tissues exhibit significant cytotoxicity to cancer cells compared non-ROS-responsive counterparts.
The development of flexible drug delivery systems that can be tuned as a function the to delivered and target disease is crucial in modern medicine. For this aim, novel amphiphilic poly(ε-caprolactone)-g-poly(ethylene glycol) (PCL-g-PEG) copolymers with well-controlled design were synthesized by thiol-yne photochemistry. grafting density copolymer amphiphilicity easily controlled via reaction parameters: concentration, time, PEG length molar ratio between PCL or photoinitiator mixture....
Abstract Cellulose‐based macroinitiators with predetermined number of initiation sites were synthesized by acylation microcrystalline cellulose AVICEL PH‐101 2‐bromoisobutyryl bromide under homogeneous reaction conditions in the N , ‐dimethylacetamide/LiCl solvent system. The influence different methods activation on efficiency and reproducibility was investigated. Best results obtained using thermal reduced pressure or newly introduced protocol based exchange to 1,4‐dioxane. Prepared used...
Abstract Time‐dependent phase separation/transition was observed in aqueous solutions of poly( N ‐isopropylmethacrylamide) the temperature range 38–42°C. The time before second appears is a function and may reach up to several hours.
Abstract Summary: This article reviews some recent developments on the determination of Band Broadening Function (BBF) in Size Exclusion Chromatography (SEC) polymers. It was carried out frame IUPAC Project: “Data Treatment Polymers”. The correction for band broadening (BB) is important quantitative determinations molar mass distribution (MMD) narrow‐distributed (or highly multimodal) polymers, and derived variables such as kinetic parameters. In narrow range a standard, BBF uniform positive...
The phase separation and its thermohysteresis in dilute aqueous solutions of polymeric components potential drug release systems (homopolymers copolymers N-isopropylacrylamide, N-isopropylmethacrylamide, N-propylmethacrylamide, N-sec-butylmethacrylamide, N-(2-hydroxypropyl)methacrylamide) was studied, both on heating cooling. Plots light transmittance vs temperature were constructed the parameters characterizing them correlated with polymer structures. Qualitative information obtained rate...
The effect of the chemical-composition heterogeneity flexible-chain binary copolymers on their separation in size-exclusion chromatography (SEC) was theoretically examined. two-parameter theory polymer solutions engaged to estimate coil size. variation molecular weight is shown for copolymer molecules which differ ratio two constituent monomeric units but have same size and, therefore, are eluted at elution volume. result applied a theoretical case analysis copolymers, composition and...
A graft copolymer of poly(4-methylstyrene-graft-2-vinylpyridine) was prepared by the living "grafting onto" method. Its molecular weight and composition analyzed size-exclusion chromatography, liquid chromatography under limiting conditions desorption, 1H NMR, light scattering. The results indicated a non-negligibly broad distribution grafting density. conformational behavior studied reversed phase with gradient elution. Targeted studies provided two discrete base-line separated fractions....
Poly(4-methylstyrene)-g-poly(methacrylic acid) (P4MS-g-PMAA) graft copolymer was synthesized by the grafting-onto method from poly(4-methylstyrene), selectively brominated on methyl groups, and "living" poly(tert-butyl methacrylate). The average degree of polymerization backbone grafts number per were 251, 21, 25, respectively. self-assembly P4MS-g-PMAA studied in methanol aqueous buffers (selective solvents for grafts). Micelles a combination static dynamic light scattering, TEM SAXS. It...
The nonuniformities of graft (co)polymers have been analyzed using the probability generating functions and their moments. nonuniformity is described by ratios averages molecular weights (co)polymers. general feature that, with increasing degree grafting polymerization backbone, a (co)polymer passes through maximum approaches more or less closely backbone (co)polymer. are function number- weight-average degrees grafts independent type degree-of-polymerization distribution. depends markedly...
The theory of Stockmayer in the modifications Thurmond and Zimm has been used for description size exclusion chromatography separation randomly branched molecules with tetrafunctional branch points. It is assumed that free chain ends, created by branching process, cause to be entrapped pores column packing time their release given exponential law characteristic monomolecular reactions. Using this assumption, anomalous elution behavior such can modeled. With increasing volume, average values...