A5064374453- Autophagy in Disease and Therapy
- Cancer Mechanisms and Therapy
- FOXO transcription factor regulation
- Signaling Pathways in Disease
- Galectins and Cancer Biology
- Peptidase Inhibition and Analysis
First Affiliated Hospital of Gannan Medical University
2021-2022
Soochow University
2021
Objective. To explore the effect and potential mechanism of T-LAK cell-originated protein kinase (TOPK) on autophagy in cutaneous squamous cell carcinoma (cSCC). Methods. Human cSCC cancer tissue paracancerous samples were collected clinically; immunohistochemistry was used to detect expression TOPK, nuclear factor κB p65 (NF-κB p65), phosphorylated inhibitor α (p-IκBα), Beclin-1, microtubule-associated 1 light chain 3 (LC3) tissue; immunofluorescence adopted coexpression NF-κB p65, p-IκBα,...
Sorafenib is the important first-standard drug for patients with advanced hepatocellular carcinoma (HCC). A major obstacle to successful treatment sorafenib resistance. However, mechanism of resistance unclear. The present study aimed determine involvement dipeptidyl peptidase-8 (DPP8) in DPP8 expression was detected using quantitative real-time PCR (qPCR) and western blot analysis. effect on examined terminal deoxynulceotidyl transferase nick-end-labeling (TUNEL), colony formation, flow...