The PKC1 gene of budding yeast encodes a homolog the alpha, beta, and gamma isoforms mammalian PKC that is proposed to regulate MAPK-activation pathway. Mutants in this pathway undergo cell lysis resulting from deficiency wall construction when they attempt grow at elevated temperatures. We show PKC1-regulated important for induced thermotolerance MPK1 protein kinase (the MAPK pathway) strongly activated by mild heat shock. This activation sustained during growth high temperature dependent...

Cyclical hormonal changes during an ovarian cycle may affect immune responses, which is crucial for the embryonic implantation. We aim to investigate whether levels and activity of T, B, NK cells change a menstrual cycle. Twenty-two normally cycling women were enrolled peripheral blood was drawn serially Intracellular cytokine expression CD3(+)CD4(+) CD3(+)CD8(+) cells, Th1/Th2 cytokine-producing T cell ratios determined using flow cytometric analysis. cytotoxicity measured by analysis at...

Only a few studies have reported the learning curve for sentinel lymph node (SLN) detection in gynecologic malignancies. We investigated SLN during robot-assisted laparoscopic surgery endometrial and cervical carcinomas.This retrospective analysis included patients with stage IA to IIA1 cancer or I III who underwent mapping using indocyanine green performed by single surgeon. Learning curves were analyzed consecutive cases rates cumulative sum (CUSUM) method.SLN was achieved 81.25% (65/80),...

The aim of this study was to evaluate the feasibility and efficacy laparoscopically-assisted staging surgery for ovarian cancer.Twenty four patients were evaluated. Among them, nineteen underwent initial laparoscopic five who incompletely staged by other institutions complete restaging surgery. procedure included pelvic lymphadenectomy, paraaortic multiple biopsies, washing cytology, infracolic omentectomy, appendectomy. Laparoscopically assisted vaginal hysterectomy bilateral...

Several studies reported that pathology of the appendix is frequently detected alongside endometriosis, especially with chronic pelvic pain. Furthermore, ovarian endometriosis a marker more extensive and intestinal disease.To evaluate feasibility efficacy incidental appendectomy in laparoscopic surgical treatment for endometrioma.One hundred six women endometrioma underwent surgery including appendectomy. Clinicopathological data were collected analysed.The main symptoms consisted lower...

The aim of this study was to determine the most relevant parameters fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) for predicting recurrence in patients with locally advanced cervical cancer.Fifty-six diagnosed International Federation Gynecology and Obstetrics (FIGO) stage IIB IVA cancer who underwent F-FDG PET/CT before definitive chemoradiotherapy were retrospectively enrolled. Various PET parameters, namely, maximum standardized uptake value, mean metabolic tumor...

Laparoscopic Myomectomy for Large MyomasThe aim of this study was to assess the feasibility and efficacy laparoscopic myomectomy (LM) large myomas.A subpopulation 51 patients with myomas 8 cm or larger in diameter selected from 155 who underwent LM at Kangbuk Samsung Hospital July 2003 November 2006.The mean age 34.9± ±5.6 yr, parity 0.6± ±0.9, had a previous operative history.The most common indication palpable abdominal mass (24 patients, 47%).The operating time 85.6± ±38.9 min, largest...

This is an observational study to determine the most relevant parameter of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for predicting recurrence in cervical cancer. Fifty-six patients with International Federation Gynecology and Obstetrics (FIGO) stage IIB-IVA cancer who underwent pretreatment 18F-FDG PET/CT were enrolled. PET parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG)...

This study aimed to determine the association between preeclampsia and postpartum development of metabolic syndrome based on pre-pregnancy status.Korean women who delivered their first child January 1, 2011, December 31, 2012, were enrolled. All subjects underwent a national health screening examination conducted by National Health Insurance Corporation 1 or 2 years prior delivery within after delivery.Among 49,065 participants, developed in 3,391 participants (6.9%). The prevalence was...

To investigate the role of TWIST1 in tumor angiogenesis epithelial ovarian cancer and to identify key molecules involved angiogenesis. small interfering RNA was transfected into A2780 cells, while a complementary DNA vector non-malignant human surface cells generate TWIST1-overexpressing cell line. evaluate how this affects angiogenesis, umbilical vein endothelial tube formation assays were performed using control lines. An antibody-based cytokine array used TWIST1-mediated After knockdown...

Matrix metalloproteinase-11 (MMP-11) promote cancer invasion and metastasis through degrading the extracellular matrix. Protein degradation by MMP-11 in tumor cells may progressively suppress surveillance activities with blocking immune response breast cancer. The aim of study is to analyze clinicopathological parameters, molecular interactions anticancer patients expression provide candidate target drugs. We investigated clinicopathologic specific gene sets, antigenicity, immunologic...

The aim of this study was to investigate the effects estrogen and receptor α (ERα) β (ERβ) on expression visfatin retinol-binding protein 4 (RBP4) by treating 3T3-L1 adipocytes with estradiol (E2), agonists antagonists. Mature were exposed E2, ERα agonist, 4,4',4''-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT), ERβ 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN), E2 antagonist, 1,3-bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride (MPP), (5R,...

Dedifferentiated endometrioid adenocarcinoma (DEAC) is a recently described, rare uterine neoplasm containing both low-grade and undifferentiated carcinoma.1 Undifferentiated carcinoma in DEAC may originate secondary to transformation or dedifferentiation of appears be more aggressive than endometrial adenocarcinoma.2 The component can misdiagnosed as the solid grade 3 adenocarcinoma.3 Therefore, accurate diagnosis this important treatment prognosis. Here we report case uterus.

Delayed diagnosis of female genital tuberculosis (FGTB) can lead to inappropriate treatment and unnecessary surgical procedures rather than standard anti-TB medication. We tried evaluate the use computed tomography (CT) imaging differentiate TB peritonitis from peritoneal carcinomatosis advanced epithelial ovarian cancer (AEOC). investigated women who underwent CT distinguish between AEOC. evaluated various features identify differences two diseases. In addition, we performed univariate...

No large-scale clinical study has been done to show the standard surgical boundary and efficacy of laparoscopic para-aortic lymphadenectomy (LPAL).Therfore, this aimed evaluate feasibility, efficacy, LPAL performed up left renal vein level in gynecological malignancies.Medical records 333 patients were retrospectively reviewed. All cases had gynecologic malignancies an operation including by a single team between November 2003 May 2018.Three hundred twenty-six underwent as part their...

There is no consensus on the extent of lymphadenectomy and appropriate patients for in low-risk with endometrial cancer. This study aimed to evaluate feasibility effectiveness laparoscopic cancer.From January 2004 May 2008, we reviewed medical records 28 low-risk, cancer; endometrioid type, grade 1 or 2, a depth myometrial invasion less than one-half myometrium. All underwent laparoscopically-assisted staging surgery.The median age body mass index were 56 years (range, 75) 25.5 kg/m(2) 21.3...

Abstract Background Multiple gestations are associated with an increased incidence of preeclampsia. However, there exists no evidence for association between multiple and development hypertension(HTN) later in life. This study aimed to determine whether HTN beyond the peripartum period. Methods In this retrospective nationwide population-based study, women who delivered a baby January 1, 2007, December 31, 2008, underwent national health screening examination within one year prior their...