A5086018496- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Pregnancy-related medical research
- Reproductive tract infections research
- Neonatal Respiratory Health Research
- Maternal and fetal healthcare
- Birth, Development, and Health
- MicroRNA in disease regulation
- Neonatal and Maternal Infections
- Prenatal Screening and Diagnostics
- Gastrointestinal disorders and treatments
- COVID-19 Impact on Reproduction
- Circular RNAs in diseases
- Maternal and Perinatal Health Interventions
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Gestational Diabetes Research and Management
- Ovarian cancer diagnosis and treatment
- Urinary Tract Infections Management
- Adrenal and Paraganglionic Tumors
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
Inje University Busan Paik Hospital
2016-2025
Wayne State University
2018-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2018-2024
National Institutes of Health
2018-2024
United States Department of Health and Human Services
2018-2024
Soonchunhyang University
2008-2024
Eunice Kennedy Shriver Center
2020-2023
International Vaccine Institute
2023
CHA Vaccine Institute (South Korea)
2021-2023
Health and Human Development (2HD) Research Network
2022
The fetus can deploy a local or systemic inflammatory response when exposed to microorganisms or, alternatively, non-infection-related stimuli (e.g., danger signals alarmins). term "Fetal Inflammatory Response Syndrome" (FIRS) was coined describe condition characterized by evidence of response, frequently result the activation innate limb immune response. FIRS be diagnosed an increased concentration umbilical cord plasma serum acute phase reactants such as C-reactive protein cytokines...
Background Microbial invasion of the amniotic cavity resulting in intra-amniotic infection is associated with obstetrical complications such as preterm labor intact or ruptured membranes, cervical insufficiency, well clinical and histological chorioamnionitis. The most widely accepted pathway for ascension microorganisms from lower genital tract. However, hematogenous dissemination oral intestine, retrograde seeding peritoneal through fallopian tubes, introduction invasive medical procedures...
Recent molecular studies concluded that the endometrium has a resident microbiota dominated by Lactobacillus spp. and is therefore similar to of vagina. These findings were largely derived from endometrial samples obtained through transcervical catheter thus prone contamination. Herein, we investigated microbial profiles mid-endometrial hysterectomy compared them with those cervix, vagina, rectum, oral cavity, controls for background DNA Microbial examined 16S rRNA gene qPCR sequencing....
Objective To determine the frequency and type of histopathologic lesions in placentas delivered by women with a normal pregnancy outcome. Methods This retrospective cohort study included placental samples from 944 singleton gestation who at term without obstetrical complications. Placental were classified into following four categories as defined Society for Pediatric Pathology our unit: (1) acute inflammation, (2) chronic (3) maternal vascular malperfusion (4) fetal malperfusion. Results...
The major challenge for obstetrics is the prediction and prevention of great obstetrical syndromes. We propose that defining diseases by combination clinical presentation disease mechanisms as inferred placental pathology will aid in discovery biomarkers add specificity to those already known.
Parturition is a well-orchestrated process characterized by increased uterine contractility, cervical ripening, and activation of the chorioamniotic membranes; yet, transition from quiescent to contractile myometrium heralds onset labor. However, cellular underpinnings human parturition in tissues are still poorly understood. Herein, we performed comprehensive study during spontaneous term labor using single-cell RNA sequencing (scRNA-Seq). First, established atlas unraveled cell...
Objective We aimed to analyze the differences in prognosis and pattern of recurrence between squamous cell carcinoma (SCC) adenocarcinoma (ADC) patients with cervical cancer. Methods retrospectively reviewed medical records 969 SCC 144 ADC who underwent radical hysterectomy pelvic lymph node dissection at Busan Paik Hospital January 1988 December 2010. Results Adenocarcinoma was associated poorer disease-free survival ( P = 0.0515) overall (OS) 0.0156) compared SCC, that this more apparent...
Abstract Problem Preterm birth is commonly preceded by preterm labor, a syndrome that causally linked to both intra‐amniotic infection and inflammation. However, the stereotypical cellular immune responses in these two clinical conditions are poorly understood. Method of study Amniotic fluid samples (n = 26) were collected from women diagnosed with labor (amniotic IL‐6 concentrations ≥2.6 ng/mL culturable microorganisms, n 10) or inflammation without 16). Flow cytometry was performed...
Abstract High-grade cervical intraepithelial neoplasia (CIN) is a precancerous lesion of cancer. The aims this study were to evaluate the risk factors for recurrence high-grade CIN and determine if specific genotype human papillomavirus (HPV) predictor recurrent CIN. Between January 2010 December 2014, 172 patients with 2+ underwent cold knife conization or loop electrosurgical excision. HPV DNA chip was used detect HPV. Recurrent lesions histologically confirmed considered be CIN2+. We...
Objective The aims of this study were to ascertain the frequency disorders villous maturation in fetal death and also delineate other placental histopathologic lesions death. Methods This was a retrospective observational cohort deaths occurring among women between January 2004 2016 at Hutzel Women's Hospital, Detroit, MI, USA. Cases comprised fetuses with beyond 20 weeks' gestation. Fetal congenital anomalies multiple gestations excluded. Controls included pregnant without...
Clinical chorioamnionitis at term is considered the most common infection-related diagnosis in labor and delivery units worldwide. The syndrome affects 5-12% of all pregnancies a leading cause maternal morbidity mortality as well neonatal death sepsis. objectives this study were to determine (1) amniotic fluid microbiology using cultivation molecular microbiologic techniques; (2) diagnostic accuracy clinical criteria used identify patients with intra-amniotic infection; (3) relationship...
The composition of the vaginal microbiota is heavily influenced by pregnancy and may factor into complications, including spontaneous preterm birth. However, results among studies have been inconsistent due, in part, to variation sample sizes ethnicity. Thus, an association between labor continues be debated. Yet, before assessing associations labor, a robust in-depth characterization throughout specific study population under investigation required. Here, we report large longitudinal (
Pregnant women are at greater risk of adverse outcomes, including mortality, as well obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear.Plasma samples were collected pregnant and non-pregnant individuals (male female) with (n = 72 pregnant, 52 non-pregnant) without 29 41 COVID-19 patients grouped asymptomatic, mild, moderate, severe, or critically ill according to NIH classifications. Proteomic profiling...