A5028818122- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Maternal and fetal healthcare
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Pregnancy-related medical research
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- COVID-19 Impact on Reproduction
- Reproductive tract infections research
- Ectopic Pregnancy Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Extracellular vesicles in disease
- Parvovirus B19 Infection Studies
- Neonatal and Maternal Infections
- IL-33, ST2, and ILC Pathways
- Sepsis Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Neurological Complications and Syndromes
- Pelvic floor disorders treatments
- Pregnancy and Medication Impact
- Sodium Intake and Health
- Neuroscience of respiration and sleep
- Bariatric Surgery and Outcomes
Prince of Songkla University
2015-2025
National Institutes of Health
2022-2024
Wayne State University
2022-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2022-2024
United States Department of Health and Human Services
2022-2024
Eunice Kennedy Shriver Center
2022-2023
Government of the United States of America
2022
Society for Maternal-Fetal Medicine
2017
Pregnant women are at greater risk of adverse outcomes, including mortality, as well obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear.Plasma samples were collected pregnant and non-pregnant individuals (male female) with (n = 72 pregnant, 52 non-pregnant) without 29 41 COVID-19 patients grouped asymptomatic, mild, moderate, severe, or critically ill according to NIH classifications. Proteomic profiling...
Abstract Objectives To determine whether placental vascular pathology and impaired exchange due to maturational defects are involved in the etiology of spontaneous preterm labor delivery cases without histologic acute chorioamnionitis. Methods This was a retrospective, observational study. Cases included pregnancies that resulted (<37 weeks), whereas uncomplicated delivered fetuses at term (≥37–42 weeks gestation) were selected as controls. Placental histological diagnoses classified into...
( Am J Obstet Gynecol . 2024;230:450.e1–450.e18. doi:10.1016/j.ajog.2023.10.002) Preeclampsia (PEC) is one of the leading causes perinatal and maternal morbidity mortality in world. PEC, characterized by high blood pressure organ damage pregnancy, occurs 3% to 7% pregnancies, has been linked intravascular inflammation an antiangiogenic state. Recent findings suggest that low performance angiogenic biomarkers women with PEC at term might be due only about half these having abnormal profile,...
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Most cases preterm occur spontaneously result from labor with intact (spontaneous [sPTL]) or ruptured (preterm prelabor rupture membranes [PPROM]) membranes. The prediction spontaneous (sPTB) remains underpowered due to its syndromic nature dearth independent analyses vaginal host immune response. Thus, we conducted largest longitudinal investigation targeting mediators, referred herein as immunoproteome, in a...
Abstract Preterm birth, the leading cause of perinatal morbidity and mortality, is associated with increased risk short- long-term adverse outcomes. For women identified as at for preterm birth attributable to a sonographic short cervix, determination imminent delivery crucial patient management. The current study aimed identify amniotic fluid (AF) proteins that could predict in asymptomatic patients cervix. This retrospective cohort included enrolled between May 2002 September 2015 who were...
The heterogeneous nature of preeclampsia is a major obstacle to early screening and prevention, molecular taxonomy disease needed. We have previously identified four subclasses based on first-trimester plasma proteomic profiles. Herein, we expanded this approach by using more comprehensive panel proteins profiled in longitudinal samples.
To determine whether the maternal plasma concentrations of cytokines are higher in pregnant women with postpartum hemorrhage (PPH) compared to without PPH.
Fetal death is a complication of pregnancy caused by multiple etiologies rather than being the end-result single disease process. Many soluble analytes in maternal circulation, such as hormones and cytokines, have been implicated its pathophysiology. However, changes protein content extracellular vesicles (EVs), which could provide additional insight into pathways this obstetrical syndrome, not examined. This study aimed to characterize proteomic profile EVs plasma pregnant women who...
To develop a predictive model using the risk factors of gestational diabetes mellitus (GDM) and construct nomogram for GDM in women during early pregnancy.A prospective study was conducted two tertiary hospitals among pregnant with age ≤14 weeks. Early diagnosed if an abnormal 100 g oral glucose tolerance test detected Carpenter Coustan criteria after 50 challenge test. The included were ACOG factors; maternal age; family history hypertensive disorder pregnancy; dyslipidemia; gravida;...
Abstract Aim The purpose of this study was to compare the accuracy National Institute for Health and Care Excellence (NICE) guidelines American College Obstetricians Gynecologists (ACOG) recommendations pre‐eclampsia (PE) screening. Methods This retrospective included 4600 Thai pregnant women who received maternity care between January 2006 December 2015 at Songklanagarind Hospital, a tertiary center in southern Thailand. medical data each participant were assessed using NICE ACOG criteria...
To describe the characteristics of amniotic fluid sludge obtained from patients in term and preterm gestations.
Early diagnosis and treatment of intra-amniotic infection is crucial. Rapid pathogen identification allows for a definite enables proper management. We determined whether the 16S amplicon sequencing performed by nanopore technique make possible rapid bacterial at species level in infection.Five cases confirmed infection, either cultivation or rDNA polymerase chain reaction (PCR) Sanger sequencing, 10 women who underwent mid-trimester genetic amniocentesis were included. DNA was extracted...
( Am J Obstet Gynecol. 2023;228:569.e1–569.e24) Pre-eclampsia, a complex and multisystemic disorder affecting significant percentage of pregnancies worldwide, is leading cause preterm birth maternal mortality. This condition not uniform can be classified into different subtypes based on gestational age underlying pathophysiological mechanisms. Understanding these crucial for predicting fetal outcomes developing targeted therapeutic strategies.
Intra-amniotic inflammation is a subclinical condition frequently caused by either microbial invasion of the amniotic cavity or sterile inflammatory stimuli, e.g., alarmins. An accumulating body evidence supports role for maternal immune activation in genesis fetal neuroinflammation and occurrence neurodevelopmental disorders such as cerebral palsy, schizophrenia, autism. The objective this study was to determine whether exposure mid-trimester intra-amniotic associated with children eight 12...
Preeclampsia and fetal growth disorders are pregnancy-specific conditions that share common pathophysiological mechanisms. Yet, why some patients develop preeclampsia while others experience restriction, or a combination of both clinical presentations, is unknown. We propose the difference in severity maternal inflammatory response can contribute to phenotypes vs. small for gestational age (SGA). To assess this hypothesis, we measured plasma concentrations soluble isoform suppression...
Abstract Objectives This study was conducted to determine whether bacteria, fungi, or archaea are detected in the amniotic fluid of patients who underwent midtrimester amniocentesis for clinical indications. Methods Amniotic samples from 692 pregnancies were tested by using a combination culture and end-point polymerase chain reaction (PCR) techniques. Intra-amniotic inflammation defined as an interleukin-6 concentration >2,935 pg/mL. Results Microorganisms 0.3% (2/692) cases based on...