A5060443881- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Breast Lesions and Carcinomas
- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- PI3K/AKT/mTOR signaling in cancer
- Spacecraft Dynamics and Control
- Endometrial and Cervical Cancer Treatments
- Lymphoma Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Spacecraft Design and Technology
- Radiation Dose and Imaging
- Cancer and Skin Lesions
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Research Studies
- Aerospace Engineering and Control Systems
- Bioinformatics and Genomic Networks
- Space Satellite Systems and Control
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Cancer Treatment and Pharmacology
- Cervical Cancer and HPV Research
State Healthcare Institution "Regional Clinical Oncological Dispensary"
2021-2023
Altai State Medical University
2022
Moscow Aviation Institute
2021
Relevance. PIK3CA belongs to the top three most frequently mutated genes in breast cancer (BC), especially estrogen receptor (ER) positive, HER2 negative BC subtype. With an approval of selective PI3K-alpha inhibitor, alpelisib, this alteration has become actionable ER+HER2- tumors. The frequency and spectrum alterations various cohorts is affected by a number factors, including distribution expression subtypes, histological types, patient age, even ethnicity.
 Aim. Aim current study...
Background. Breast cancer is one of the most common female malignancies. Molecular diagnostic methods tumor profiling allow us to analyze individual characteristics, identify new prognostic and predictive markers. Aim. To increase efficacy systemic therapy for breast reduce inappropriate prescriptions using data on molecular characteristics; develop a polygenic panel ensure tailored approach cancer. Materials methods. We analyzed 84 tissue samples from pre- postmenopausal women with...
Background. By 2020, breast cancer (BC) has become the most frequent malignancy in world. The common type of BC is HR+/HER2-negative cancer,2540% which harbors PIK3CA mutations that affect catalytic subunit PI3K protein. alterations are actionable, as such neoplasms can be treated with a combination fulvestrant and inhibitor alpelisib. As have an extremely versatile effect on characteristics tumor cell, numerous associations various clinico-pathological traced.
 Aim. Our aim was to...
This study was undertaken to analyze the effectiveness of cytological diagnostics endocervical adenocarcinomas. We compared conventional liquid-based cytology, histology, immunohistochemistry, and molecular testing. A total 25 adenocarcinomas, including adenocarcinomas in situ , were diagnosed using methods over a year. Liquid-based cytology ensured better detection glandular differentiation signs than cytology. After testing for human papillomavirus (HPV), we performed retrospective...
The aim of the study is to estimate potentiality cytological diagnostics different types mucin producing carcinomas breast. Materials and methods . Cytological evidences investigation 35 patients with mucinous mass in specimens were studied. Different which had been diagnosed by method identified retrospectively. Results “Pure” mucous divided into two types: hypocellular (A) hypercellular (B) (n = 9 (25.7 %) 14 (40 %), respectively). Mixed (mucous carcinoma invasive no special type...
Background. Individual molecular characteristics of a tumor can serve as basis for tailored approach to therapy, prediction the disease course and outcome, timely treatment correction in cancer patients. Tumor genomic profiling allows more precise assessment an individual manner. Accurate identification HER2 status breast is crucial clinical decisions appropriate strategy. Aim. To increase efficacy systemic therapy cancer, reduce inappropriate prescribing, ensure using information on tumor....
Background . Individual molecular characteristics of a tumor can serve as basis for tailored approach to therapy, prediction the disease course and outcome, timely treatment correction in cancer patients. Tumor genomic profiling allows more precise assessment an individual manner. Accurate identification HER2 status breast is crucial clinical decisions appropriate strategy. Aim. To increase efficacy systemic therapy cancer, reduce inappropriate prescribing, ensure using information on tumor....
The purpose of the study: determination ALK gene status (mutation) in patients with stage TI-II adenocarcinoma relationship survival, stage, size, metastases bronchopulmonary lymph nodes and amplification Her2/Neu. Materials. 98 I-II patients. Cases a mutation account for 20 (4.8% without randomization). There was used immunohistochemical method situ hybridization. Results. survival rate lower than cases metastases: 8.3 ± 7.8% 40.9 13% respectively. None lived up to 9 years contrast...
Purpose: Identification of risk factors that influence the outcome patient, their ranking on contribution to treatment, as well determining possibility additional diagnostic evaluation and correction in deviation at preoperative preparation stage with subsequent construction a prognostic model. Material methods: The study included patients who received treatment surgical department A. I. Burnasyan Federal Medical Biophysical Center from January 2009 July 2017, including workers nuclear...
В-cell lymphoma is manifested by a variety of forms, which makes it difficult to establish an accurate lifetime diagnosis and has unfavorable prognosis. Therefore, every case primary B-cell the breast, demands attention close doctors different specialties. The feature presented investigation lymphoma, that primarily affects right breast. This type breast cancer develops as chronic mastitis, confirming forms its manifestation, what cause difficulties in making diagnosis.