A5045831288- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Esophageal Cancer Research and Treatment
- Nerve injury and regeneration
- Cancer Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
Umeå University
2021-2024
Abstract Background Breast cancer is the most common in women. Cancer cells can persist a prolonged dormant state for years without any clinical evidence of disease creating an urgent need to better understand molecular mechanisms leading relapse. This study aimed identify extracellular matrix (ECM) components associated with hypoxia-induced breast dormancy. The effects selected ECM proteins on cell proliferation were analyzed, along their correlation established prognostic markers human...
Autologous bone transplantation is the principal method for reconstruction of large defects. This technique has limitations, such as donor site availability, amount needed and morbidity. An alternative to this tissue engineering with marrow-derived mesenchymal stem cells (BMSCs). In study, our aim was elucidate benefits culturing BMSCs in 3D compared traditional 2D culture. an initial screening, we combined four different biogels: unmodified type I collagen (Col I), methacrylate (ColMa),...
The use of mesenchymal stem cells (MSCs) for the development tissue-engineered constructs has advanced in recent years. However, future clinically approved products require following good manufacturing practice (GMP) guidelines. This includes using alternatives to xenogeneic-derived cell culture supplements avoid rejection transplants. Consequently, human platelet lysate (PLT) been adopted as an affordable and effective alternative foetal bovine serum (FBS) traditional 2D cultures. little is...
Injuries to large peripheral nerves are often associated with tissue defects and require reconstruction using autologous nerve grafts, which have limited availability result in donor site morbidity. Peripheral nerve-derived hydrogels could potentially supplement or even replace these grafts. In this study, three decellularization protocols based on the ionic detergents sodium dodecyl sulfate (P1) deoxycholate (P2), organic solvent tri-n-butyl phosphate (P3), were used prepare hydrogels. All...