A5071899181- Respiratory viral infections research
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Viral gastroenteritis research and epidemiology
- Congenital Diaphragmatic Hernia Studies
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- T-cell and B-cell Immunology
- Thermal Regulation in Medicine
- Animal Virus Infections Studies
- Viral Infections and Vectors
- vaccines and immunoinformatics approaches
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
University of Iowa
2017-2022
Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as influenza and SARS. However, the relative contribution of memory in providing against syncytial virus (RSV) infection is currently unclear. To address this knowledge gap, we utilized a prime-boost immunization approach to induce robust cell responses absence RSV-specific CD4 antibodies. Unexpectedly, RSV mice with pre-existing led exacerbated weight loss, pulmonary disease, lethal immunopathology. The...
Abstract Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in young children. The T cell response plays a critical role facilitating clearance an acute RSV infection, and memory responses are vital for protection against secondary exposures. Tissue-resident (TRM) cells have been identified as subset that reside nonlymphoid tissues providing long-term immunity. There currently limited information regarding establishment longevity TRM elicited...
Despite being a leading cause of severe respiratory disease, there remains no licensed syncytial virus (RSV) vaccine. Neutralizing antibodies reduce the severity RSV-associated but are not sufficient for preventing reinfection. In contrast, role memory CD8 T cells in protecting against secondary RSV infection is less established. We recently demonstrated that high-magnitude efficiently reduced lung viral titers following infection, induced fatal immunopathology was mediated by IFN-γ. To...
Abstract Many acute viral infections target tissue Mϕs, yet the mechanisms of Mϕ-mediated control viruses are poorly understood. Here, we report that CD40 expressed by peritoneal Mϕs restricts early infection a broad range RNA viruses. Loss expression enhanced virus replication as 12–24 h and, conversely, stimulation signaling with an agonistic Ab blocked infection. With cell populations infected filovirus, wild-type (WT) Ebola (EBOV), or BSL2 model virus, recombinant vesicular stomatitis...
Respiratory syncytial virus (RSV) is the leading cause of severe respiratory tract infection in infants and young children, but no vaccine currently available. Live-attenuated vaccines represent an attractive immunization approach; however, balancing attenuation while retaining sufficient immunogenicity efficacy has prevented successful development such a vaccine. Recently, recombinant RSV strain lacking gene that encodes matrix (M) protein (RSV M-null) was developed. The M required for...
Effective CD8 T cell responses are vital for the control of chronic viral infections. Many factors host immune response contribute to maintenance effector versus exhaustion during infection. Specific MHC alleles and degree heterogeneity associated with enhanced function human However, it is currently unclear what extent genetics influences establishment In order examine impact non-MHC on development infection, an F1 cross B10.D2 x B6 (D2B6F1) BALB.B BALB/c (BCF1) mice were infected clone-13...
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection and hospitalization in infants. It well established that both CD4+ CD8+ T cells are critical for mediating viral clearance but also contribute to induction immunopathology following RSV infection. C57BL/6 mice often used study cell responses given wide variety genetically modified animals available. To date, few RSV-derived epitopes have been identified mice. Using an overlapping peptide library...
Abstract Respiratory syncytial virus (RSV) is the leading cause of severe respiratory tract infection in infants and young children. However, despite extensive efforts, there remains no licensed RSV vaccine. Recently, a recombinant infectious strain lacking gene for matrix (M) protein (M-null RSV) was developed as potential vaccine candidate. The M required reassembly virion following expression within host cell. Infection with M-null produces viral proteins but does not result generation...
Critical Care Medicine: January 2020 - Volume 48 Issue 1 p 262 doi: 10.1097/01.ccm.0000625992.45017.63