A5100673093- Geological and Geochemical Analysis
- High-pressure geophysics and materials
- Antimicrobial agents and applications
- Geochemistry and Geologic Mapping
- Nanoplatforms for cancer theranostics
- Wound Healing and Treatments
- Antimicrobial Peptides and Activities
- biodegradable polymer synthesis and properties
- Ferroptosis and cancer prognosis
- earthquake and tectonic studies
- Advanced Polymer Synthesis and Characterization
- Acute Kidney Injury Research
- Polymer Surface Interaction Studies
- Bone Tissue Engineering Materials
- Bone and Joint Diseases
- MRI in cancer diagnosis
- Advanced Nanomaterials in Catalysis
- Nanopore and Nanochannel Transport Studies
- Supramolecular Self-Assembly in Materials
- Oral microbiology and periodontitis research
- Burn Injury Management and Outcomes
- Trace Elements in Health
- Sulfur Compounds in Biology
- Curcumin's Biomedical Applications
- Protist diversity and phylogeny
Tongji University
2018-2024
Institute of Geology and Geophysics
2020-2024
Shanghai Tenth People's Hospital
2020-2024
Chinese Academy of Sciences
2020-2024
Southern Medical University
2024
University of Chinese Academy of Sciences
2020-2024
Shantou University
2023
Harbin University of Science and Technology
2020
Diabetic wounds are difficult to heal due recurrent bacterial infection, decreased proliferation, and migration of epidermal endothelial cells. This is related impaired leukocyte function low blood concentrations H2S in diabetic patients. Herein, an antibacterial polymersome-based wound dressing spray was demonstrated for complete healing. The designed polymersome self-assembled from poly(ε-caprolactone)24-block-poly[lysine15-stat-(S-aroylthiooxime)23] [PCL24-b-P(Lys23-stat-SATO15)], where...
Nanozymes could mimic the catalytic activity of natural enzymes, then stimulate Fenton reaction for reactive oxygen species overproduction and lipid peroxidation, ultimately induce ferroptosis to exert anticancer effects.
Chronic diabetic wound patients usually show high glucose levels and systemic immune disorder, resulting in reactive oxygen species (ROS) cell dysfunction, prolonged inflammation, delayed healing. Herein, we prepared an antioxidant immunomodulatory polymer vesicle for treatment. This is self-assembled from poly(ε-caprolactone)36-block-poly[lysine4-stat-(lysine-mannose)22-stat-tyrosine)16] ([PCL36-b-P[Lys4-stat-(Lys-Man)22-stat-Tyr16]). Polytyrosine polypeptide that can scavenge ROS....
Nanobowls with controlled openings and interior holes are created by self-assembly of homopolymers hydrogen bonding π–π interaction.
There is a growing demand for antibacterial materials around the world in recent years because they can be used preventing pathogen infection, which one of major threats to human health. However, mechanical damage may weaken their protective effect since bacteria invade through cracks material. Therefore, with self-healing ability, spontaneously healed, exhibit better reliability and longer lifespan. In this article, we prepared series low-cost polymer blends polymer/small molecule blend...
Abstract Computed tomography (CT) angiography is powerful for the diagnosis of vascular diseases. Unfortunately, this method usually requires a high dosage iodinated contrast agents, which can lead to severe elevation reactive oxygen species (ROS) levels within kidneys. This causes oxidative stress, apoptosis, and hence contrast‐induced nephropathy (CIN), leading cause iatrogenic renal failure, especially patients with insufficiency. Herein, route shown circumvent such problems usage...
Delayed implant-associated infection is an important challenge, as the treatment involves a high risk of implant replacement. Mussel-inspired antimicrobial coatings can be applied to coat variety implants in facile way, but adhesive 3,4-dihydroxyphenylalanine (DOPA) group prone oxidation. Therefore, antibacterial polypeptide copolymer poly(Phe7-stat-Lys10)-b-polyTyr3 was designed prepare coating upon tyrosinase-induced enzymatic polymerization for preventing infections. Both...
Despite considerable progress in promoting infected diabetic wound healing, the complex pathological characteristics urge development of injectable supersoft hydrogels with synergistic antibacterial, antioxidant, anti-inflammatory, and angiogenic functions. Herein, we propose a versatile strategy for preparing DNA hydrogel dressings to promote healing bacteria-infected wounds. These were formed through coassembly chains magnesium pyrophosphate (Mg2PP) during rolling-circle amplification...
Abstract Acute kidney injury (AKI) is a critical condition with wide range of triggers that cause heavy burden on public health. Despite its high incidence and mortality, the treatment AKI still highly relies hemodialysis, which costly usually accompanied by severe complications. Therefore, development new therapeutic targets methods for urgently needed. Herein, ferroptosis‐targeting strategy rationally designed ferroptosis‐inhibitive polypeptide‐based polymersomes (polypeptosomes, FIPs)...
Abstract Periodontitis is the leading cause of tooth loss in adults. Initially triggered by bacterial infection, it characterized subsequent dysregulation mitochondrial homeostasis, to ongoing periodontal tissue. Mitophagic flux, a critical physiological mechanism for maintaining compromised periodontitis. Additionally, increased release reactive oxygen species (ROS) exacerbates damage. In this study, ginsenoside Rd (Rd)‐loaded antioxidative polymersome (RdAP) designed, which self‐assembled...