A5067244330- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Pelvic and Acetabular Injuries
- Cervical and Thoracic Myelopathy
- Clinical practice guidelines implementation
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Management of metastatic bone disease
- Orthopaedic implants and arthroplasty
- Anesthesia and Pain Management
- Spinal Hematomas and Complications
- Bone fractures and treatments
- Spinal Dysraphism and Malformations
- Manufacturing Process and Optimization
- Intraoperative Neuromonitoring and Anesthetic Effects
- Bone Tumor Diagnosis and Treatments
- Case Reports on Hematomas
- Orthopedic Infections and Treatments
- Delphi Technique in Research
- Artificial Intelligence in Healthcare and Education
- Pregnancy-related medical research
Schulthess-Klinik
2016-2025
University of Bern
2006-2023
University Hospital of Bern
2023
Helmholtz-Institute Ulm
2009-2010
AO Foundation
2009-2010
Joachim Herz Stiftung
2009-2010
Nuffield Orthopaedic Centre
2010
Royal Orthopaedic Hospital
2010
Charité - Universitätsmedizin Berlin
2005-2009
Universidad Iberoamericana
2009
Abstract Vertebral endplate damage is associated with intervertebral disc (IVD) degeneration (DD) in vivo as confirmed by in‐vitro investigations. Our aims were to further characterize the process of DD using an vitro full‐organ culture model and elucidate whether significant or impact loading alone pivotal for initiation DD. Rabbit spinal segments (n = 80) harvested, subjected pure axial 40) a custom‐made device, cultured 28 days. The applied threshold energy (0.76 J) induced fractures 21...
In Brief Study Design. Ex vivo in vitro study evaluating a novel intervertebral disc/endplate culture system. Objectives. To establish whole-organ disc model for the of degeneration vitro, including characterization basic cell and organ function. Summary Background Data. With current models endplate degeneration, it remains difficult to investigate complex metabolism signaling cascades. contrast, more controlled but simplified systems using isolated cells or fragments are due unconstrained...
(1) Cage subsidence in spine surgery is a frequent clinical challenge. This study aimed to assess novel screw augmentation technique for Transforaminal Lumbar Interbody Fusion cadavers of reduced bone mineral density (BMD). (2) Forty human lumbar vertebrae (BMD 84.2 ± 24.4 mgHA/cm3, range 51–119 mgHA/cm3) were assigned two groups: augmenting and control group. The comprised the placement additional subcortical screws. Ten constructs per group loaded load-to-failure protocol ten cyclically....
Abstract It is generally agreed that the mechanical environment of intervertebral disc cells plays an important role in maintaining a balanced matrix metabolism. The precise mechanism by which signals are transduced into poorly understood. Osmotic changes extracellular (ECM) thought to be involved. Current in‐vitro studies on this topic mostly short‐term and show conflicting data reaction subjected osmotic partially due heterogenous often substantially‐reduced culture systems. aim study was...
Study Design. Single-center retrospective study of prospectively collected data, nested within the Eurospine Spine Tango data acquisition system. Objective. The aim this was to assess patient-rated outcome and complication rates associated with lumbar fusion procedures in three different age groups. Summary Background Data. There is a general reluctance consider spinal elderly patients due increased likelihood complications. Methods. Before at 3, 12, 24 months after surgery, completed...
Cage subsidence after instrumented lumbar spinal fusion surgery remains a significant cause of treatment failure, specifically for posterior or transforaminal interbody fusion. Recent advancements in computational techniques and additive manufacturing, have enabled the development patient-specific implants implant optimization to specific functional targets. This study aimed introduce novel full-scale topology formulation that takes structural response adjacent bone structures into account...
Generative AI is revolutionizing patient education in healthcare, particularly through chatbots that offer personalized, clear medical information. Reliability and accuracy are vital AI-driven education. How effective Large Language Models (LLM), such as ChatGPT Google Bard, delivering accurate understandable on lumbar disc herniation? Ten Frequently Asked Questions about herniation were selected from 133 questions submitted to three LLMs. Six experienced spine surgeons rated the responses a...