A5017330984- RNA and protein synthesis mechanisms
- Chromosomal and Genetic Variations
- Plant Virus Research Studies
- Veterinary medicine and infectious diseases
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Viral Infectious Diseases and Gene Expression in Insects
- Protein purification and stability
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
Mettler-Toledo (United States)
2021
University of Maryland, Baltimore
2015-2017
PIWI-interacting RNAs (piRNAs) are thought to silence transposon and gene expression during development. However, the roles of piRNAs in somatic tissues largely unknown. Here we report identification 555 human lung bronchial epithelial (HBE) non-small cell cancer (NSCLC) lines, including 295 that do not exist databases termed as piRNA-like sncRNAs or piRNA-Ls. Distinctive piRNA/piRNA-L patterns observed between HBE NSCLC cells. piRNA-like-163 (piR-L-163), top downregulated piRNA-L cells,...
Lung cancer is the leading cause of cancer-related death worldwide. Although advanced drugs have benefitted patients, therapeutic success has largely been hampered because rapid development resistance. Here we report that PIWI-interacting RNA likes (piR-Ls), a novel type functional sncRNAs, play key roles in chemoresistance to cisplatin (CDDP)-based chemotherapy lung squamous cell carcinoma (LSCC). piR-L-138 was upregulated upon CDDP-based both LSCC cells and patient-derived xenograft (PDX)...
The focus of this study was to examine the small-scale adsorption process Tetanus Toxoid (TT) as a model protein antigen aluminum phosphate (AlPO4) and oxyhydroxide (AlOOH) adjuvants with real-time monitoring by in-line ReactIR™, ParticleTrack™ based on Focused Beam Reflectance Measurement (FBRM) EasyViewer™ probes. AlPO4 AlOOH TT using monitored in reactors. Conformational changes were infrared probe ReactIR, whereas particle formation associated measured size, count, imaging tools, such...