A5074432990- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Extracellular vesicles in disease
- Cervical Cancer and HPV Research
- Calcium signaling and nucleotide metabolism
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Ocular Diseases and Behçet’s Syndrome
- Gut microbiota and health
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Retinal and Optic Conditions
- RNA Research and Splicing
- RNA regulation and disease
- Probiotics and Fermented Foods
- Autoimmune and Inflammatory Disorders Research
- Protein Degradation and Inhibitors
Virginia Commonwealth University
2023-2025
Mashhad University of Medical Sciences
2018-2022
Cells exposed to proteotoxic stress invoke adaptive responses aimed at restoring proteostasis. Our previous studies have established a firm role for the transcription factor Nuclear factor-erythroid derived-2-related factor-1 (Nrf1) in responding elicited by inhibition of cellular proteasome. Following proteasome inhibition, Nrf1 mediates new synthesis, thus enabling cells mitigate stress. Here, we report that under similar circumstances, multiple components autophagy-lysosomal pathway (ALP)...
ABSTRACT Proteasome inhibitor drugs are currently used in the clinic to treat multiple myeloma and mantle cell lymphoma. These inhibitors cause accumulation of undegraded proteins, thus inducing proteotoxic stress consequent death. However, cancer cells counteract this effect by activating an adaptive response through transcription factor Nuclear erythroid 2-related 1 (NRF1, also known as NFE2L1). NRF1 induces transcriptional upregulation proteasome autophagy/lysosomal genes, thereby...
The transcription factor MEIS1 belongs to the 3-amino acid loop extension (TALE) family of homeodomain proteins which plays various functions in normal and tumor cell progression. canonical WNT/β-catenin pathway governs a plethora biological processes including proliferation, differentiation, development. In present study, effect gene silencing was assessed on WNT genes esophageal squamous carcinoma (ESCC) cells. Along with packaging plasmids, pLKO.1-MEIS1 plasmid cotransfected into HEK293T...
Rheumatoid arthritis (RA) is known as one of important autoimmune disorders which can lead to joint pain and damage throughout body. Given that internal (ie, genetic epigenetic alterations) external factors lifestyle changes, age, hormones, smoking, stress, obesity) involved in RA pathogenesis. Increasing evidence indicated cellular molecular alterations play critical roles the initiation progression RA. Among various targets signaling pathways, microRNAs (miRNAs) their regulatory networks...
Abstract Background Lung cancer is a leading cause of morbidity and mortality worldwide. Several studies have suggested that Human papillomavirus (HPV) infection an important risk factor in the development lung cancer. In this study, we aim to address role HPV mechanistically by examining induction inflammation epithelial-mesenchymal transition (EMT) virus. Methods case-control tissue samples were collected from 102 cases with 48 controls. We examined presence DNA also viral genotype...
<title>Abstract</title> Synovial Sarcoma (SS) is driven by the SS18::SSX fusion oncoprotein and ultimately refractory to therapeutic approaches. alters ATP-dependent chromatin remodeling BAF (mammalian SWI/SNF) complexes, leading degradation of canonical (cBAF) complex amplified presence an SS18::SSX-containing non-canonical (ncBAF or GBAF) that drives SS-specific transcription program tumorigenesis. We demonstrate activates SUMOylation SSs are sensitive small molecule SAE1/2 inhibitor,...
Long non-coding ribonucleic acids (LncRNAs) are recently known for their role in regulating gene expression and the development of cancer. Controversial results indicate a correlation between tissue LncRNA content extracellular vesicles. The present study aimed to evaluate different LncRNAs non-small cell lung cancer (NSCLC) patients tumor tissue, adjacent non-cancerous (ANCT), exosome-mediated lncRNA. Tumor ANCT, as well serum samples 168 patient with NSCLC, were collected. GHSROS,...
Abstract Background: The ubiquitin-proteasome system (UPS) and autophagy-lysosomal pathway (ALP) are critical intracellular protein degradation pathways. In response to proteasome dysfunction, cells initiate compensatory autophagy manage proteotoxic stress, which impacts cancer therapy efficacy. Despite current insights, the exact molecular mechanisms underlying induction of due impaired function remain unclear. transcription factor nuclear erythroid-2-related 1 (NRF1) is master regulator...