A5057295224- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Endometrial and Cervical Cancer Treatments
- Photoreceptor and optogenetics research
- Ovarian cancer diagnosis and treatment
- Glioma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Mass Spectrometry Techniques and Applications
- Free Radicals and Antioxidants
- Microbial Metabolism and Applications
- Endoplasmic Reticulum Stress and Disease
- bioluminescence and chemiluminescence research
- Oral Health Pathology and Treatment
- BRCA gene mutations in cancer
- Protein Interaction Studies and Fluorescence Analysis
- Immunotherapy and Immune Responses
- Cancer and Skin Lesions
- Intraperitoneal and Appendiceal Malignancies
- Lung Cancer Treatments and Mutations
- Glutathione Transferases and Polymorphisms
- Reproductive tract infections research
- Microbial Inactivation Methods
- Spinal Fractures and Fixation Techniques
- Hemoglobin structure and function
- Cancer survivorship and care
Carol Davila University of Medicine and Pharmacy
2012-2024
Institutul Oncologic Bucuresti
2014-2024
Clinical Emergency Hospital Bucharest
2021
Institutul Cantacuzino
2021
Institutul Clinic Fundeni
2012
Hai phong University Of Medicine and Pharmacy
2010
Vascular endothelial growth factor (VEGF) plays an important role in tumor progression ovarian cancer, but the complex mechanism and interaction with oxidative stress are not fully understood.A prospective study included 52 patients adenocarcinoma stage IIIA-IV. Serum VEGF reactive oxygen species (ROS) such as malondialdehyde ceruloplasmin were measured.VEGF levels elevated (mean 1014.7 ± 165 pg/mL), especially macroscopic residual disease (1058 vs. 810 pg/mL, p = 0.0001). Median...
Green tea extracts (GTEs) as well their main component, the polyphenol epigallocatechin gallate (EGCG), are known for versatile antioxidant, antimicrobial, antitumoral or anti-inflammatory effects. In spite of huge beneficial action, there is increasing evidence that under certain conditions green and its components can be detrimental to living organisms. Using Saccharomyces cerevisiae strains with various defects in response oxidative stress, we found GTEs EGCG act synergy visible light,...
In 2021, the 5th edition of WHO Classification Tumors Central Nervous System (WHO-CNS5) was published as sixth volume international standard for brain and spinal cord tumor classification. The most remarkable practical change in current classification involves grading gliomas according to molecular characterization. IDH mutant (10%) wild-type tumors (90%) are two different entities that possess unique biological features various clinical outcomes regarding treatment response overall...
Optical manipulation of Saccharomyces cerevisiae cells with high density green photons conferred protection against the deleterious effects UV radiation. Combining chemical screening irradiation yeast cells, it was noted that relied on presence intact unfolded protein response (UPR) pathway to exert their protective effect and low Ca 2+ conditions boosted effect. UPR inducers tunicamycin, dithiotreitol calcium chelators augmented light in a synergic action UV‐induced damage....
Verrucous carcinoma (VC) is a very rare variant of squamous cell the cervix, difficult to point out in histology because its benign appearance. We present case 29-year-old woman with locally advanced cervical VC who underwent radiotherapy followed by radical hysterectomy. After local relapse and despite pelvic exenteration, her condition deteriorated. Treatment choice surgery, risk anaplastic transformation under irradiation, raising chances distant spread converting this rather benign-like...
Skin squamous cell carcinoma (SCC) represents a major public health concern due to its high incidence and potential for local invasion metastasis. Compared recurrence, metastatic SCC an even greater therapeutic challenge. Once distant metastasis occurs, the disease becomes incurable, treatment focuses on palliation prolonging survival. The immune microenvironment of is characterized by infiltration cells, including tumor-infiltrating lymphocytes. In addition direct cytotoxic effects,...
Background and Objectives: The treatment of advanced metastatic lung cancer is multimodal, it coordinated by a multidisciplinary team. Anxiety depression occur frequently in patients with cancer, creating considerable discomfort therapeutic management. At the same time, these psychoemotional symptoms affect patients’ quality life. Objective: This research seeks to identify correlations both between anxiety performance statuses, as well type treatment: radiotherapy, chemotherapy, tyrosine...
e13008 Background: Glioblastoma (GBM) is the most common and aggressive primary brain tumour. Despite treatment, prognosis of patients with GBM remains poor. The study aimsto assess outcome treated in our centre after combined treatment (surgery, radiotherapy multiple cycle chemotherapy). Methods: Data from medical files 90 (43M/47F), confirmed Karnofsky Performance Status >70, department between 2008-2013 were retrospectively reviewed. Median age at diagnosis was 54 years (range 21-74)....
Background and Objectives: This study aimed to assess the impact of clinical prognostic factors propose a score that aids clinician’s decision in estimating risk for patients practice. Materials Methods: The included 195 diagnosed with ovarian adenocarcinoma. therapeutic strategy involved multidisciplinary decisions: surgery followed by adjuvant chemotherapy (80%), neoadjuvant (16.4%), only selected cases (3.6%). Results: After median follow-up 68 months, terms progression-free survival...
Abstract Osteosarcoma represents a rare primary tumor of the bone, but it ranks 5th among children and adolescents. When diagnosed, many patients already have disseminated disease at subclinical level. Current treatment includes surgery chemotherapy. Radiotherapy is not commonly indicated, especially given radioresistant characteristic this type cancer usually administered for residual after surgery, inoperable tumors or in palliation, such as whole lung irradiation. The purpose paper was to...