A5000505246- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Treatments and Mutations
- Multiple and Secondary Primary Cancers
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- HER2/EGFR in Cancer Research
- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Inflammatory Biomarkers in Disease Prognosis
- Radiopharmaceutical Chemistry and Applications
- Brain Metastases and Treatment
- Cutaneous Melanoma Detection and Management
- Ferroptosis and cancer prognosis
Carol Davila University of Medicine and Pharmacy
2016-2025
Institutul Oncologic Bucuresti
2015-2025
Clinical Emergency Hospital Bucharest
2021-2022
Institutul Cantacuzino
2021-2022
Emergency University
2022
Avila University
2017
(1) Introduction: A Romanian woman is diagnosed with cervical cancer every two hours; the country ranks second in Europe terms of mortality and incidence rate this disease. This paper aims to identify main reasons that have led situation, focusing on measures taken by Ministry Health for prevention type cancer-national programs screening HPV vaccination. (2) Materials methods: We performed a study based available secondary data from National Statistics Institute, World Organization Bucharest...
This study aimed to assess the impact of ongoing COVID-19 pandemic on cancer patients, known be immune-compromised due disease itself, oncological treatments and adjuvant medicines use such as steroids. Overall survival was determined for patients with infection stratification according comorbidities complications performed.This prospective included ninety confirmed by PCR testing performed before each cycle chemotherapy or every two weeks during radiotherapy between May December 2020 in...
The aim of our study is to present the particularities a specific subset gynecological cancer patients in Romania. We review synchronous neoplasia (SGN) treated Bucharest Oncological Institute's surgery departments over decade. Between 2012 and 2022, 7419 female with genital malignancies were treated. identified 36 invasive primary cancers (0.5%) 12 cases one another pelvic (rectal/bladder). All recurrent, metastatic, or metachronous tumors detected excluded. Demographic data, personal...
Vascular endothelial growth factor (VEGF) plays an important role in tumor progression ovarian cancer, but the complex mechanism and interaction with oxidative stress are not fully understood.A prospective study included 52 patients adenocarcinoma stage IIIA-IV. Serum VEGF reactive oxygen species (ROS) such as malondialdehyde ceruloplasmin were measured.VEGF levels elevated (mean 1014.7 ± 165 pg/mL), especially macroscopic residual disease (1058 vs. 810 pg/mL, p = 0.0001). Median...
2505 Background: Most pts receiving immune checkpoint inhibitors do not respond to treatment or relapse. FS222 is a novel affinity optimized, tetravalent bispecific PD-L1/CD137 antibody. FS222’s structure allows for potent, PD-L1-dependent, CD137 activation across wide range of dose levels, and designed provide selective agonism in the tumor. We present data from ongoing, FIH, open-label, phase I trial advanced solid tumors. Methods: Pts with pretreated tumors received increasing doses an...
Background/Objectives: In Romania, breast cancer is the second most common cancer, third leading cause of death, and prevalent overall. De novo advanced-stage often presents in clinical practice, treatment decisions are best made a multidisciplinary tumor board (MTD) involving surgeons, radiotherapists, medical oncologists. Significant advances systemic therapies, particularly progression-free survival (PFS) overall (OS), have surpassed traditional palliative mastectomy radiotherapy for...
Background/Aim: This case report navigates through the challenges of a complex clinical scenario involving germ cell tumors (GCTs), one most frequently encountered malignancies in adolescents and young adults. Case report: We present an 18-year-old patient exhibiting atypical manifestations, prompting emergent extensive surgical intervention. Upon admission to Oncology Department, adolescent presented with jaundice dyspnea, being diagnosed pure non-seminomatous embryonal carcinoma, poor-risk...
6019 Background: BI 765063 is a first-in-class, humanized IgG4 monoclonal antibody that binds the V1 allele of signal regulatory protein α (SIRPα) and blocks ‘don’t eat me’ SIRPα/CD47 axis. This leads to reactivation innate antitumor responses, restoring phagocytosis antigen presentation. In Phase Ia/Ib trial in pts with advanced solid tumors (NCT03990233), ± ezabenlimab was well tolerated no dose-limiting toxicities preliminary efficacy observed (Kotecki et al, ESMO 2021). Ib study...
Background: Immune checkpoint inhibitors (ICIs) used for the treatment of advanced melanoma have yielded significant results, with long-term responses and improved survival rates, but not all treated patients. Therefore, predictive biomarkers response to ICI therapy been intensively explored. Our study aimed evaluate dynamics peripheral blood lymphocyte variation their correlation a set related inflammatory factors in Nivolumab-treated Methods: The immunophenotypic assessment immune cell...
Many countries had initial success with HPV vaccination campaigns worldwide. The vaccine coverage during the COVID-19 pandemic dropped consistently. aim of our research is to assess barriers and facilitators current Romanian campaign.An analytical cross-sectional observational survey was conducted in general population; a self-administered questionnaire used.1122 responders were interviewed; 666 (59.36%) parents, 67 (5.97%) vaccinated themselves. A multinominal logistic regression carried...
(1)Background: Among new anti-angiogenetic agents being developed and everchanging guidelines indications, the question of benefits/safety ratio remains unclear. (2)Methods: we have conducted a systematic review meta-analysis 25 randomized controlled trials (15487 patients), evaluating overall survival – OS, progression free survival– PFS toxicity (grade ≥3 adverse effects, type number all effects. (3)Results: analysis showed improvement pooled-PFS (HR 0.72, 95%CI...
Cervical cancer ranks third in frequency among female cancers globally and causes high mortality worldwide. Concurrent chemoradiotherapy improves the overall survival cervical patients by 6% but it can cause significant acute late toxicities affecting patient quality of life. Whole pelvis radiotherapy doses 10-20 Gy lead to myelosuppression subsequent hematological since pelvic bones contain half bone marrow tissue.
Endometrial stromal sarcoma (ESS) is a rare tumor, predominantly occurring as primary tumor of the uterus. Rare cases extrauterine ESS (EESS) have been reported. Low-grade (LG-ESS) more common than high-grade (HG-ESS). We present five and one case EESS. All received external radiotherapy (EBRT) at Radiotherapy Department Emergency Clinical Hospital 'Sfantul Apostol Andrei' Galati, during 2004-2020. Five underwent EBRT in two-dimensional (2D) technique only patient with three-dimensinal...
(1) Background: The aim of our study is to reveal the advantages and limitations use