A5033882798- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Mitochondrial Function and Pathology
- Isotope Analysis in Ecology
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- RNA modifications and cancer
- Advanced Proteomics Techniques and Applications
- GDF15 and Related Biomarkers
- Analytical Chemistry and Chromatography
- Metabolism, Diabetes, and Cancer
Cornell University
2022-2025
MIND Research Institute
2022-2025
Weill Cornell Medicine
2022-2025
Mass spectrometry imaging (MSI) is a powerful technology used to define the spatial distribution and relative abundance of metabolites across tissue cryosections. While software packages exist for pixel-by-pixel individual metabolite limited target pairs ratio imaging, research community lacks an easy computing application tool that images any pairs. Importantly, recognition correlated may contribute discovery unanticipated molecules in shared metabolic pathways. Here, we describe...
Mass spectrometry imaging (MSI) is a powerful technology used to define the spatial distribution and relative abundance of metabolites across tissue cryosections. While software packages exist for pixel-by-pixel individual metabolite limited target pairs ratio imaging, research community lacks an easy computing application tool that images any pairs. Importantly, recognition correlated may contribute discovery unanticipated molecules in shared metabolic pathways. Here, we describe...
Mitochondrial cardiomyopathies are fatal diseases, with no effective treatment. Alterations of heart mitochondrial function activate the integrated stress response (ISRmt), a transcriptional program affecting cell metabolism, biogenesis, and proteostasis. In humans, mutations in CHCHD10, protein unknown function, were recently associated dominant multi-system whose pathogenic mechanisms remain to be elucidated. Here, CHCHD10 knockin mutant mice, we identify an extensive cardiac metabolic...
Abstract Mitochondrial diseases are a heterogeneous group of monogenic disorders that result from impaired oxidative phosphorylation (OXPHOS). As neuromuscular tissues highly energy‐dependent, mitochondrial often affect skeletal muscle. Although genetic and bioenergetic causes OXPHOS impairment in human myopathies well established, there is limited understanding metabolic drivers muscle degeneration. This knowledge gap contributes to the lack effective treatments for these disorders. Here,...
Mutations in CHCHD10, a mitochondrial protein with undefined functions, are associated autosomal dominant diseases. Chchd10 knock-in mice harboring heterozygous S55L mutation (equivalent to human pathogenic S59L) develop fatal cardiomyopathy caused by CHCHD10 aggregation and proteotoxic integrated stress response (mtISR). In mutant hearts, mtISR is accompanied metabolic rewiring characterized increased reliance on glycolysis rather than fatty acid oxidation. To counteract this rewiring, were...
Mass spectrometry imaging (MSI) is a powerful technology used to define the spatial distribution and relative abundance of metabolites across tissue cryosections. While software packages exist for pixel-by-pixel individual metabolite limited target pairs ratio imaging, research community lacks an easy computing application tool that images any pairs. Importantly, recognition correlated may contribute discovery unanticipated molecules in shared metabolic pathways. Here, we describe...
Mass spectrometry imaging (MSI) is a powerful technology used to define the spatial distribution and relative abundance of metabolites across tissue cryosections. While software packages exist for pixel-by-pixel individual metabolite limited target pairs ratio imaging, research community lacks an easy computing application tool that images any pairs. Importantly, recognition correlated may contribute discovery unanticipated molecules in shared metabolic pathways. Here, we describe...
Mass spectrometry imaging (MSI) is a powerful technology used to define the spatial distribution and relative abundance of structurally identified yet-undefined metabolites across tissue cryosections. While numerous software packages enable pixel-by-pixel individual metabolites, research community lacks discovery tool that images all metabolite ratio pairs. Importantly, recognition correlated pairs informs unanticipated molecules contributing shared metabolic pathways, uncovers hidden...
Abstract Mutations in CHCHD10 , a mitochondrial protein with undefined functions, are associated autosomal dominant diseases. Chchd10 knock-in mice harboring heterozygous S55L mutation (equivalent to human pathogenic S59L) develop fatal cardiomyopathy caused by aggregation and proteotoxic integrated stress response (mtISR). In mutant hearts, mtISR is accompanied metabolic rewiring characterized increased reliance on glycolysis rather than fatty acid oxidation. To counteract this rewiring,...