A5070454799- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- COVID-19 Impact on Reproduction
- Fetal and Pediatric Neurological Disorders
- Ectopic Pregnancy Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Breast Cancer Treatment Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Renal Diseases and Glomerulopathies
- COVID-19 and healthcare impacts
- Complement system in diseases
- Reproductive System and Pregnancy
- Cerebrospinal fluid and hydrocephalus
- Uterine Myomas and Treatments
- Parvovirus B19 Infection Studies
- Advanced Radiotherapy Techniques
- Maternal and Perinatal Health Interventions
- Ultrasound in Clinical Applications
- Elder Abuse and Neglect
- Adenosine and Purinergic Signaling
- Nerve injury and regeneration
- Cognitive Abilities and Testing
- Systemic Lupus Erythematosus Research
- Brain Metastases and Treatment
University of Naples Federico II
2019-2025
Federico II University Hospital
2018-2024
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2016-2022
Objective: The objective of this research is to demonstrate the release SARS-CoV-2 Spike (S) antibodies in human milk samples obtained by patients who have been vaccinated with mRNABNT162b2 vaccine. Methods: Milk and serum were collected 10 volunteers 20 days after first dose 7 seven second Anti-SARS-CoV-2 S measured Elecsys® ECLIA assay (Roche Diagnostics AG, Rotkreuz, Switzerland), a quantitative electrochemiluminescence immunometric method. Results: At sample, anti-SARS-CoV-2 detected all...
Breast cancer is the most common tumor in women and represents leading cause of death. Radiation therapy plays a key-role treatment all breast stages. Therefore, adoption evidence-based treatments warranted, to ensure equity access standardization care clinical practice.This national document on highest available data was developed endorsed by Italian Association Clinical Oncology (AIRO) Cancer Group.We analyzed literature regarding radiation therapy, using SIGN (Scottish Intercollegiate...
To build and validate a predictive model of placental accreta spectrum (PAS) in patients with placenta previa (PP) combining clinical risk factors (CRF) US MRI signs.Our retrospective study included PP from two institutions. All underwent examinations for suspicion PAS. CRF consisting maternal age, cesarean section number, smoking hypertension were retrieved. signs suggestive PAS evaluated. Logistic regression analysis was performed to identify and/or associated considering histology as the...
Background: Leptin, a protein predominantly produced by adipocytes, plays crucial role in regulating energy balance, inflammation, immunity, and fetal growth. During pregnancy, maternal serum leptin levels increase, peaking the second trimester, with placental production contributing to this rise. Leptin has also been identified tissues, its concentration umbilical cord blood correlates birth weight. This study aimed evaluate concentrations rural Burundian women living marginal nutritional...
Abstract Background The COronaVIrus Disease 2019 (COVID-19) has spread in Italy since February 2020, inducing the government to call for lockdown of any activity, apart primary needs, during months March–May 2020. During lockdown, a reduction admissions and hospitalizations ischemic diseases was noticed. Purpose this study observe if there been same trend Accident & Emergency (A&E) unit also obstetric-gynecological conditions. Methods Medical records electronic clinical databases...
Pregnancy is characterized by significant immunological changes and a cytokine profile, as well vitamin deficiencies that can cause problems for the correct development of fetus. Defensins are small antimicrobial peptides part innate immune system involved in several biological activities. Following that, this study aims to compare levels various cytokines investigate role defensins between pregnant women with confirmed COVID-19 infection without any defined risk factor. TNF-α, TGF-β, IL-2...
COVID-19 is characterized by the immune system's overreaction resulting in a 'cytokine storm', consisting massive release of cytokine into bloodstream, leading to local and systemic inflammatory response. This clinical picture further complicated case infection patients with peculiar immunological status, such as pregnancy. In this paper, we focused on Interferon-γ, which plays pivotal immunomodulatory role normal pregnancy fetal development, well defense against pathogens. study, compared...
To date, the impact of COVID-19 pandemic on world’s health, economics and politics is still heavy, efforts to mitigate virus transmission have caused remarkable disruption. From early onset pandemic, generated by SARS-CoV-2 spread, scientific community was aware its vulnerable individuals, including pregnant women. The purpose this paper highlight pitfalls ethical dilemmas emerging from management severe respiratory distress in women order add evidence topic through an debate. In...
Neurotrophins, such as BDNF and NGF, are overexpressed in tumor cells cervical cancer, HIV infection is associated with the upregulation of neurotrophin expression. Therefore, we aimed to investigate whether NGF preneoplastic disease from HIV-infected women. Women lesions (cervical intraepithelial neoplasia grade 2 or 3) were prospectively enrolled grouped according their status. Samples Loop Electrosurgical Excision Procedure (LEEP) for suspected cancer obtained, immunohistochemistry was...
The lack of reliable methods for preeclampsia (PE) early diagnosis limits the opportunities timely prevention, and treatment. This study aims to identify alterations biochemical parameters immune system activity build a panel markers that can support diagnosis. For this study, we recruited 30 pregnant women: 10 healthy women (CTR); with (EP); late (LP). We evaluated lipid profile and, by gene expression, assessed PCSK9, IL-2, IL-6, IL-8, IL-10, TNF-α TGF-β. Moreover, both serum levels...
The aim of this study was, firstly, to analyze the histopathological characteristics placentas in women with uneventful pregnancies and affected by COVID-19 at time delivery; secondly, correlate histological findings maternal neonatal characteristics. In our single-center prospective observational study, 46 from term uncomplicated singleton patients a documented SARS-CoV-2 infection delivery underwent examination. Despite normal feto-maternal outcome, most (82.6%) presented signs vascular...
Antiphospholipid Antibody Syndrome (APS) is a systemic autoimmune disease characterized by acquired hypercoagulability with the possible development of venous, arterial, and microvascular thrombosis. We report rare case Libman–Sacks tricuspid valve endocarditis in 38-year-old pregnant woman at 15 weeks gestation unknown primary antiphospholipid syndrome. During routine cardiac examination echocardiography performed for previous episode pleuropericarditis, large, mobile mass irregular edges...
Congenital hydrocephalus and ventriculomegaly can be diagnosed reliably with prenatal ultrasound Magnetic Resonance Imaging (MRI). Unilateral is uncommon, the prognosis depends on etiology postnatal management. Here, we present a case of 32-years-old woman diagnosis unilateral associated stenosis foramen Monro. an uncommon feature that detected prenatally MRI. In isolated Monro good.