Photothermal agents can harvest light energy and convert it into heat, offering a targeted remote-controlled way to destroy carcinomatous cells tissues. Inspired by the biological organization of polypeptides porphyrins in living systems, here we have developed supramolecular strategy fabricate photothermal nanodots through peptide-modulated self-assembly photoactive porphyrins. The self-assembling nature induces formation J-aggregates as substructures nanodots, thus enables fabrication with...

An injectable and self-healing collagen-gold hybrid hydrogel is spontaneously formed by electrostatic self-assembly subsequent biomineralization. It demonstrated that such collagen-based hydrogels may be used as an material for local delivery of therapeutic agents, showing enhanced antitumor efficacy.

Abstract Peptide‐tuned self‐assembly of functional components offers a strategy towards improved properties and unique functions materials, but the requirement many different lack understanding complex structures present high barrier for applications. Herein, we report photosensitive drug delivery system photodynamic therapy (PDT) by simple dipeptide‐ or amphiphilic amino‐acid‐tuned photosensitizers (PSs). The assembled nanodrugs exhibit multiple favorable therapeutic features, including...

Supramolecular photosensitizer nanodrugs that combine the flexibility of supramolecular self-assembly and advantage spatiotemporal, controlled drug delivery are promising for dedicated, precise, noninvasive tumor therapy. However, integrating robust blood circulation targeted burst release in a single nanodrug platform can simultaneously improve therapeutic performance reduce side effects is challenging. Herein, we demonstrate multicomponent coordination strategy versatile potent development...

The transition of peptides and proteins from the solution phase into fibrillar structures is a general phenomenon encountered in functional aberrant biology increasingly exploited soft materials science. However, fundamental molecular events underpinning early stages their assembly subsequent growth have remained challenging to elucidate. Here, we show that liquid-liquid separation solute-rich solute-poor phases step leading nucleation supramolecular nanofibrils building blocks, including...

Photothermal nanomaterials that integrate multimodal imaging and therapeutic functions provide promising opportunities for noninvasive targeted diagnosis treatment in precision medicine. However, the clinical translation of existing photothermal nanoagents is severely hindered by their unclear physiological metabolism, which makes them a strong concern biosafety. Here, utilization biliverdin (BV), an endogenic near-infrared (NIR)-absorbing pigment with well-studied metabolic pathways, to...

Elegant self-assembling complexes by the combination of proteins/peptides with functional chromophores are decisively responsible for highly efficient light-harvesting and energy transfer in natural photosynthetic systems. Mimicking through synthetic peptides is attractive due to their advantanges programmable primary structure, tunable self-assembly architecture easy availability comparison naturally occuring proteins. Here, an overview recent progresses area biomimetic nanoarchitectonics...

Abstract Long‐range structural order and alignment over different scales are of key importance for the regulation structure functionality in biology. However, it remains a great challenge to engineer assemble such complex functional synthetic systems with length from simple biologically relevant molecules, as peptides porphyrins. Herein we describe successful introduction hierarchical long‐range dipeptide‐adjusted porphyrin self‐assembly by thermodynamically driven self‐orienting assembly...

Abstract Clinical translation of curcumin has been highly obstructed by the rapid degradation and poor tissue absorption this agent. Herein, we report on generation supramolecular nanoagents through amino acid coordination driven self‐assembly to simultaneously increase biological stability tumor accumulation curcumin. The was significantly improved both molecular stacking. sizes these can be readily manipulated facilitate accumulation. These favorable therapeutic features, together with...

Prototypes of biosystems provide good blueprints for the design and creation biomimetic systems. However, mimicking both sophisticated natural structures their complex biological functions still remains a great challenge. Herein, chloroplast mimics have been fabricated by one-step bioinspired amino acid mineralization simultaneous integration catalytically active units. Hierarchically structured crystals were obtained metal-ion-directed self-assembly cystine (the oxidized dimer cysteine),...

Photothermal nanomedicine based on self-assembly of biological components, with excellent biosafety and customized performance, is vital significance for precision cancer therapy. However, the programmable design photothermal remains extremely challenging due to vulnerability variability noncovalent interactions governing supramolecular self-assembly. Herein, it reported that amino acid encoding a facile potent means construct nanodrugs controlled therapeutic activities. It found amount type...

Nanoassemblies based on self-assembly of biological building blocks are promising in mimicking the nanostructures, properties, and functionalities natural enzymes. However, it remains a challenge to design biomimetic nanozymes with tunable nanostructures enhanced catalytic activities starting from simple biomolecules. Herein, construction nanoassemblies through coassembly an amphiphilic amino acid hemin is reported. The morphologies resulting readily controlled by tuning molar ratio between...

Abstract Photocatalytically active, multi‐chambered, biomolecule‐based microspheres were prepared by hierarchical co‐assembly of simple dipeptides and porphyrins. The colloidal are highly hydrated consist a network J‐aggregate nanoscale substructures that serve as light‐harvesting antennae with relatively broad spectral cross‐section considerable photostability. These optical properties can be exploited in photocatalytic reactions involving inorganic or organic species. Taken together, these...

Abstract Molecular evolution, with self‐organization of simple molecules towards complex functional systems, provides a new strategy for biomimetic architectonics and perspectives understanding the processes life. However, there remain many challenges to fabrication systems comprising different types units, which interact one another perform desired functions. Challenges arise from lack stability, dynamic properties, functionalities that reconcile given environment. A co‐assembling fiber...

Tumor-responsive nanocarriers are highly valuable and demanded for smart drug delivery particularly in the field of photodynamic therapy (PDT), where a quick release photosensitizers tumors is preferred. Herein, it demonstrated that protein-based nanospheres, prepared by electrostatic assembly proteins polypeptides with intermolecular disulfide cross-linking surface polyethylene glycol coupling, can be used as versatile tumor-responsive vehicles effective PDT. These nanospheres capable...

An injectable dipeptide–fullerene supramolecular hydrogel is designed for photodynamic antibacterial therapy.

The inactivation of photosensitizers before they reach the targeted tissues can be an important factor, which limits efficacy photodynamic therapy (PDT). Here, we developed co-assembled nanohybrids graphene oxide (GO) and albumin/photosensitizer that have a potential for protecting from environment releasing them in sites, allowing enhanced PDT. were prepared by loading pre-assembled nanoparticles chlorin e6 (Ce6) bovine serum albumin (BSA) on GO via non-covalent interactions. protection to...

Abstract Self-assembly is omnipresent in nature. While natural self-assembly systems are complicated structure, the simplification of while maintaining their inherent functionalities has proven to be a highly promising route towards artificial nanoarchitectonics with great potential for application. In this review, we summarize our recent works on self-assembling peptide-based nanoarchitectonics, where peptides simple molecular structure can modulate assembly various species flexible and...

Abstract The transition of peptides and proteins from the solution phase into fibrillar structures is a general phenomenon encountered in functional aberrant biology increasingly exploited soft materials science. However, fundamental molecular events underpinning early stages their assembly subsequent growth have remained challenging to elucidate. Here, we show that liquid–liquid separation solute‐rich solute‐poor phases step leading nucleation supramolecular nanofibrils building blocks,...

Hydrogels self-assembled by biologically based building blocks including peptides and proteins can be used as an ideal drug delivery platform present great promise for biomedical applications. Herein, photodynamic antitumor therapy on injectable N-fluorenylmethoxycarbonyl diphenylalanine (Fmoc-FF)/poly-l-lysine (PLL) hydrogels was achieved encapsulation of the photosensitive Chlorin e6 (Ce6), exhibit multiple favorable therapeutic features, shear-thinning self-healing properties, good...

Abstract Peptide‐tuned self‐assembly of functional components offers a strategy towards improved properties and unique functions materials, but the requirement many different lack understanding complex structures present high barrier for applications. Herein, we report photosensitive drug delivery system photodynamic therapy (PDT) by simple dipeptide‐ or amphiphilic amino‐acid‐tuned photosensitizers (PSs). The assembled nanodrugs exhibit multiple favorable therapeutic features, including...

Abstract In diverse biological systems, the oxidation of tyrosine to melanin or dityrosine is crucial for formation crosslinked proteins and thus realization their structural, biological, photoactive functionalities; however, predominant factor in determining pathways this chemical evolution has not been revealed. Herein, we demonstrate tyrosine‐containing amino acid derivatives, peptides, that selective produce can be readily realized by manipulating oxygen concentration reaction system....