A5056212584- Pain Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Erythrocyte Function and Pathophysiology
- Mass Spectrometry Techniques and Applications
- Pharmaceutical Economics and Policy
- Adenosine and Purinergic Signaling
- Advanced Proteomics Techniques and Applications
- Pharmaceutical studies and practices
- Sphingolipid Metabolism and Signaling
University of Florida
2020-2022
Different software and algorithms are available for peak picking in nontargeted metabolomics each may have its own strengths limitations. The choice of pick method can significantly influ-ence the results obtained, including number identity metabolites detected, their quantification, subsequent biomarker analysis. impact by different tools an untargeted metabolomics-based study is largely understated. This compares two popular open-source cancer cells, tissues, bio-fluids: XCMS MZmine 2....
Spectrometric methods with rapid biomarker detection capacity through untargeted metabolomics are becoming essential in the clinical cancer research. Liquid chromatography-mass spectrometry (LC-MS) is a rapidly developing metabolomic-based technique due to its high sensitivity, reproducibility, and separation efficiency. However, translation diagnostics often limited long data acquisition times (∼20 min/sample) laborious sample extraction procedures when employed for large-scale studies....
Abstract Emerging evidence implicates the sphingosine-1-phosphate (S1P) receptor subtype 1 (S1PR1) in development of neuropathic pain. Continued investigation signaling pathways downstream S1PR1 are needed to support antagonists. In rodents, intrathecal (i.th.) injection SEW2871, a selective agonist, activates nod-like family, pyrin domain containing 3 (NLRP3) inflammasome, increases interleukin-1β (IL-1β) and causes behavioral hypersensitivity. I.th. IL-1β antagonist blocks SEW2871-induced...