The effects of saffron (Crocus sativus L.) on mood disorders have already been established. More recently, its anti-neoplastic provoked a great attention. This study aims to assess the crocin administration during doxorubicin-based chemotherapy breast cancer anxiety, depression, and toxicity profile. Seventy-two patients with non-metastatic Her2/neu positive or triple negative were enrolled randomly assigned receive either 30 mg/day placebo [2:2]. Beck's Depression Anxiety Inventories used...

Crocin is the major active carotenoid of saffron (Crocus sativus L.). Its pluripotent effects have led to a growing body literature investigating its antitumor properties as well diverse potentials for mood stabilization, normal tissue protection, and inflammation reduction; However, there gap in clinical trials testing this substance cancer patients. In randomized, double-blind, placebo-controlled trial, patients with newly diagnosed esophageal squamous cell carcinoma were randomly assigned...

The human multidrug resistance gene 1 (MDR1) encodes a plasma membrane, P-glycoprotein (Pgp), which functions as the transmembrane efflux pump for various structurally unrelated anticancer agents and toxins. Polymorphisms in MDR1 may have an impact on expression function of Pgp, thereby influencing susceptibility to diseases, including cancer. Recently, silent C3435T polymorphism exon 26 has been reported be associated with decreased Pgp TT genotype carriers thus it alter physiological...

The allele frequency of the multidrug resistance 1 (MDR1) gene C3435T polymorphism differs with different ethnic populations, such as Asian, African, and Caucasian. This has been reported to be associated increase gastric cancer.The objective this study was find out association cancer incidence MDR1 in an Iranian population.In study, 48 patients were diagnosed. Genomic DNA extracted by a salting-out method. studied polymerase chain reaction (PCR)-restriction fragment length method, using...

Purpose Mucinous adenocarcinomas account for about 10% of all colorectal cancers. This study aimed to investigate the prognostic impact mucinous histologic subtype on oncologic outcomes in patients with cancer. Methods retrospective was performed at two large tertiary university hospitals. We analyzed characteristics, factors, and survival cancer who were treated followed up between 2000 2013. Results Totally, 144 1,268 a adenocarcinoma (11.4%) had subtype. Statistically significant results...

Squamous cell carcinoma (SCC) is the most common malignancy of oral cavity. A relationship between human papilloma virus (HPV) infection and prognosis cavity SCC (OCSCC) has been discussed before.We investigated prevalence rate HPV status in patients with OCSCC, its effects on clinicopathological characteristics tumors patients' prognosis.Sections formalin-fixed, paraffin-embedded tissue blocks from 114 histopathologically confirmed OCSCC cases were this study. Polymerase chain reaction...

Small cell esophageal carcinoma (SCEC) is a highly aggressive and rare neoplasm.This study aimed to report the characteristics, prognostic factors, treatment outcomes of 22 patients with SCEC.This brief was carried out by reviewing medical records newly histologically proven SCEC that were treated between 2000 2010 at 2 tertiary academic hospitals. All potential variables, including patients' tumor features, modalities analyzed establish their influence on survival rates.This conducted 7...

To survey the proportion of stages at presentation disease without a screening program, among population breast cancer patients that is as representative sample country in distinct period.The current study found female who were referred to oncology centers northeastern Iran over thirty-three-year period from 1980 2012.Four thousand divided into three time periods consisting 521 cases 1990, 1178 1991 2001, and 2302 2002 2012. While there was no difference proportions T1 T3 tumors, T2 tumors...

Esophageal carcinoma is a common malignancy in the North East of Iran. Combined modality treatments have been adopted to improve survival patients with esophageal carcinoma. In this trial, we evaluated efficacy and toxicity preoperative concurrent chemoradiotherapy protocol locally advanced carcinoma.Between 2006 2011, eligible underwent radiotherapy chemotherapy 3-4 weeks later, esophagectomy. Pathologic response, overall rate, toxicity, feasibility were evaluated.One hundred ninety-seven...

<i>Objectives:</i> Although Iran, and especially the northeast of country, is known as one areas in world where esophageal cancer most prevalent, there no information on survival rate patients affected with this disease region. To address issue, we conducted a study comprehensive enough to provide accurate an estimate possible. Any finding related area may be considered representative Iran. <i>Methods:</i> Esophageal who were consecutively referred oncology centers...

Intensity-modulated radiotherapy is developed as a replacement for 3-dimensional conformal radiation therapy. Considering the difference in costs and effectiveness of these interventions, aim this study was to compare cost intensity-modulated therapy three-dimensional treatment head neck cancer east Iran.A Markov model including six states based on xerostomia dysphagia estimate incremental ratio from perspective societal. Cost quality life data were collected 97 respondents via checklist...

Purpose Local recurrence is a common failure pattern in adenocarcinoma of the cecum. This study aimed to investigate potential role adjuvant radiation therapy on oncologic outcomes patients with Materials and Methods retrospective was carried out at three large tertiary university hospitals. We analyzed characteristics, prognostic factors, survival 162 cecum that were treated followed up between 2000 2013. All had undergone right hemicolectomy received chemotherapy (n = 48) or without 114)...

Background: Deep inspiration breath-hold (DIBH) is known as a radiotherapy method for thetreatment of patients with left-sided breast cancer. In this method, patient under exposureonly while he/she at the end deep cycle and holds his/her breath. thissituation, volume lung tissue enhanced heart pushed away from thetreating breast. Therefore, dose these patients, using DIBH, experiences considerable decline compared to free breathing treatment. There are few commercialized systems...

Background: Cancer is the third leading cause of death in Iran. Novel chemotherapeutic agents can lead to considerable improvements cancer treatment, although using these requires special skills and experiences. The aim this study was evaluate impact a short course education on nurses’ knowledge attitude. Methods: Overall, 24 nurses participated educational course, supervised by several clinical/radiation oncologists. During two-week period, protocols chemotherapy, complications associated...

Purpose. This study aimed to assess the impact of 3 anastomotic techniques after laparoscopic rectal cancer resection. Methods. In a cross-sectional study, data 155 patients who underwent surgery for were retrieved. An anastomosis was created between left colon and anal canal with different methods: coloanal protective ileostomy (group A), without ostomy B), delayed C). The rates problems (leakage, peritonitis, collection) calculated each treatment method. Multivariate analysis used verify...

Abstract A 76-year-old man with castration-resistant prostate cancer and widespread skeletal metastases underwent 2 cycles of 177 Lu–prostate-specific membrane antigen (PSMA) 617 therapy in our department. Whole-body Lu-PSMA scan after the first cycle showed diffuse PSMA-avid lesions, whereas no PSMA uptake was evident kidneys minimal by salivary glands (super scan). After 6 weeks, he received second dose whole-body treatment remarkable resolution normal glands. To best knowledge, this is...

Acanthosis nigricans (AN) is a condition with an important characteristics of symmetrical areas thickened skin grayish brown hyperpigmentation. The mucosa may show papillomatous surface, or without Lips and sites at risk trauma be affected palmoplantar keratosis might also present. In some rare cases, acanthosis presents as sign internal neoplasia, mostly gastrointestinal cancer, called malignant (MAN).In this study, 55-year-old female Iranian patient (MAN) reported. She was seeking esthetic...