A5044484080- Epigenetics and DNA Methylation
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Phytoplasmas and Hemiptera pathogens
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- Pregnancy and preeclampsia studies
- Renal and related cancers
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- Nail Diseases and Treatments
- Genetic Syndromes and Imprinting
- Antifungal resistance and susceptibility
- Bladder and Urothelial Cancer Treatments
- Prenatal Screening and Diagnostics
- Plant Pathogenic Bacteria Studies
- Urological Disorders and Treatments
- Streptococcal Infections and Treatments
- Cancer Immunotherapy and Biomarkers
- Hedgehog Signaling Pathway Studies
- Genomics and Chromatin Dynamics
- Acute Lymphoblastic Leukemia research
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Immune cells in cancer
University of Otago
2016-2025
Maurice Wilkins Centre
2025
United States Department of Health and Human Services
1985-2009
St James's University Hospital
2005
Cancer Research UK
2005
The Christie NHS Foundation Trust
1998
Cancer Research UK Manchester Institute
1998
National Center for Infectious Diseases
1983
AID Atlanta
1981
National Institute of Allergy and Infectious Diseases
1969
In investigating six cases of blastomycosis in two school groups that had separately visited an environmental camp northern Wisconsin June 1984, we identified a large outbreak the disease and isolated Blastomyces dermatitidis from soil at beaver pond near camp. Of 89 elementary-school children 10 adults groups, 48 (51 percent) 95 evaluated September blastomycosis. cases, 26 (54 were symptomatic (the median incubation period was 45 days; range, 21 to 106 days). No weeks before or after these...
The uroplakins are widely regarded as urothelium-specific markers of terminal urothelial cytodifferentiation. This study investigated the expression four uroplakin genes, UPIa, UPIb, UPII and UPIII, in a wide range normal human tissues to determine tissue specificity advanced transitional cell carcinoma (TCC) examine gene primary metastatic disease. In urinary tract, all were expressed by urothelium UPIII was also prostatic glandular epithelium. UPIa appeared be urothelium-specific, but UPIb...
The distribution of the two mating types in soil and among isolates from human infection was studied. Nine hundred thirty-nine 184 clinical obtained 13 states which organism is endemic were tested for their types. ratio + –types 1: 1, whereas there a 7 (−): 1 (+) ratio. mycelia – type converted to unicellular form vitro more readily than type.
Abstract The extent of variation in DNA methylation patterns healthy individuals is not yet well documented. Identification inter-individual epigenetic important for understanding phenotypic and disease susceptibility. Using neutrophils from a cohort individuals, we generated base-resolution maps to document variation. We identified 12851 autosomal variably methylated fragments (iVMFs). Gene promoters were the least variable, whereas gene body upstream regions showed higher methylation....
Alkylpurine-DNA-N-glycosylase (APNG) null mice have been generated by homologous recombination in embryonic stem cells. The status of the animals was confirmed at mRNA level reverse transcription-PCR and inability cell extracts tissues from knockout (ko) to release 3-methyladenine (3-meA) or 7-methylguanine (7-meG) 3H-methylated calf thymus DNA vitro. Following treatment with DNA-methylating agents, increased persistence 7-meG found liver sections APNG ko comparison wild-type (wt) mice,...
The occurrence of pulmonary blastomycosis in 4 persons Bigfork, Minnesota (population 464), prompted an epidemiologic investigation. search for additional cases was concentrated the 3 families these men and another family close friends. investigation revealed 8 probable among members families; had abnormal chest roentgenograms, but only mild or subclinical illnesses. patients with proven were skin tested showed dermal hypersensitivity to blastomycin, not histoplasmin. Six reacted while 1...
Reduced representation bisulfite sequencing (RRBS), which couples conversion and next generation sequencing, is an innovative method that specifically enriches genomic regions with a high density of potential methylation sites enables investigation DNA at single-nucleotide resolution. Recent advances in the Illumina sample preparation protocol technology have vastly improved throughput capacity. Although new now widely used, unique challenges associated multiplexed RRBS libraries on this...
The placenta is a vital fetal exchange organ connecting mother and baby. Specialised placental epithelial cells, called trophoblasts, are essential for adequate function. Trophoblasts transform the maternal vasculature to allow efficient blood flow facilitate nutrient uptake. Placental development in part regulated by epigenetic mechanisms. However, our understanding of how DNA methylation contributes human trophoblast differentiation limited. To better understand genome-wide differences...
Wilms tumour is a childhood that arises as consequence of somatic and rare germline mutations, the characterisation which has refined our understanding nephrogenesis carcinogenesis. Here we report loss function mutations in TRIM28 predispose children to tumour. Loss this transcriptional co-repressor, role nephrogenesis, not previously been associated with cancer. Inactivation TRIM28, either or somatic, occurred through inactivating heterozygosity epigenetic silencing. TRIM28-mutated tumours...
We evaluated the diagnostic value of antibody to Blastomyces dermatitidis A precipitin arcs for identifying B. cultures by exoantigen technique with 88 isolates from United States and Canada, 12 Africa, 1 each India Israel. In addition, we studied 190 mycelial-form other fungi which could be confused antigenically or morphologically dermatitidis. Antigen extracts all North American isolates, Indian Israeli one African reacted antibody. The anti-A serum did not react antigens 11 any...
Invasive lobular carcinoma (ILC) of the breast is believed to develop from in situ lesions, atypical hyperplasia (ALH), and (LCIS). Down-regulation cell-cell adhesion protein E-cadherin a defining feature cancer (LBC) already occurs ALH LCIS. Apart mutational mechanisms, epigenetic silencing gene (CDH1) thought be involved down-regulation has been observed at high frequency ILC. Whether CDH1 promoter methylation present lesions thus contributes initiation LBC not established. We examined...
Nine cases of lymphocutaneous sporotrichosis in children occurred Kansas the fall 1969. All had played stacks baled prairie hay from which Sporotrichum schenckii was recovered. This outbreak is, to our knowledge, largest reported and first due contaminated hay. It is suggested that when adequately exposed material are as susceptible adults.
In January 1981, informal surveillance of acute histoplasmosis in Indianapolis, Indiana, revealed a marked increase disease activity for the last quarter 1980. Fifty-one patients with onset during this period were identified through review hospital admissions, emergency room visits, and serologic records at Indianapolis hospitals Indiana State Board Health. retrospective case-control study, authors found significant association between developing working or attending classes 2 sq mi (5.2 km)...
Journal Article THE USE OF FORMALIN TO KILL HISTOPLASMA CAPSULATUM AT AN EPIDEMIC SITE Get access F. E. TOSH, TOSH Chief 2Chief Pulmonary Mycoses Unit, Kansas City Field StationCDC, 2002 West 39th Street, City, 66103 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. J. WEEKS, WEEKS Supervisory Microbiologist 3Kansas PFEIFFER, PFEIFFER Regional Engineer 4State Department of Health, Health ServiceMason Iowa 50402 S. L. HENDRICKS, HENDRICKS Public Veterinarian...
Some of the epidemiologic aspects blastomycosis were determined based on a study 127 human and 110 canine cases conducted in Arkansas from April 1960 to January 1966. Epidemiologic included case distribution, age, sex, race or breed, occupation, contacts cases, epidemics, annual incidence, seasonal environmental factors. Environmental factors altitude, soil types, forest climatic conditions, Arkansas, southwest region appeared be high incidence area. This area had total 39 (rate—13/100,000)...
Aberrant promoter DNA methylation has been reported in childhood acute lymphoblastic leukaemia (ALL) and the potential to contribute its onset outcome. However, few reports demonstrate consistent, prevalent dense methylation, associated with tumour-specific gene silencing. By screening candidate genes, we have detected frequent of TESTIN (TES) promoter. Bisulfite sequencing showed that 100% ALL samples (n = 20) were methylated at TES promoter, whereas matched remission 5), normal bone marrow...