A5061154522- Bone Tissue Engineering Materials
- Magnesium Alloys: Properties and Applications
- Advanced Drug Delivery Systems
- Gut microbiota and health
- Silk-based biomaterials and applications
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Glycosylation and Glycoproteins Research
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Electrospun Nanofibers in Biomedical Applications
- Infectious Aortic and Vascular Conditions
- Viral Infectious Diseases and Gene Expression in Insects
- RNA modifications and cancer
- Osteoarthritis Treatment and Mechanisms
- Aluminum Alloys Composites Properties
- Drug Solubulity and Delivery Systems
- Immunotherapy and Immune Responses
- Carbohydrate Chemistry and Synthesis
- Gastrointestinal motility and disorders
- Infant Nutrition and Health
- RNA Research and Splicing
- Proteoglycans and glycosaminoglycans research
- Ureteral procedures and complications
- Cancer-related gene regulation
Sana Biotechnology (United States)
2022-2024
Northeastern University
2017-2022
Universidad del Noreste
2020
University of California, Riverside
2011-2015
Abstract This article presents an investigation on the effectiveness of magnesium and its alloys as a novel class antibacterial biodegradable materials for ureteral stent applications. Magnesium is lightweight metallic material with beneficial properties use in medical devices. Ureteral one such example device that widely used to treat canal blockages clinically. The bacterial colony formation coupled encrustation surface from extended often leads clinical complications contributes failure...
Hydrogels possess high water content and closely mimic the microenvironment of extracellular matrix. In this study, we created a hybrid hydrogel containing type II collagen, hyaluronic acid (HA), polyethylene glycol (PEG) incorporated magnetic nanoparticles into hydrogels collagen-HA-PEG to produce nanocomposite (MagGel) for cartilage tissue engineering. The results showed that both MagGel gel (Gel) were successfully cross-linked responded an external magnet while maintaining structural...
The consumption of generally regarded as safe emulsifiers has increased, and been associated with an increased prevalence inflammatory bowel metabolic diseases, well altered microbiome. mucus barrier, which selectively controls the transport particulates microorganisms to underlying epithelial layer, previously shown be by dietary salts lipids. However, potential impact on protective its permeability, structural changes are not clear. In this study, we analyzed in barrier both passively...
Myeloid cells play critical and diverse roles in mammalian physiology, including tissue development repair, innate defense against pathogens, generation of adaptive immunity. As that show prolonged recruitment to sites injury or pathology, myeloid represent therapeutic targets for a broad range diseases. However, few approaches have been developed gene editing these cell types, likely owing their sensitivity foreign genetic material virus-based manipulation. Here we describe optimized...
Abstract Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of incompletely understood pathophysiology predominantly affecting premature infants. While NEC associated with microbial invasion intestinal tissues, and mucus modulates interactions between microbes underlying variations in barrier properties NEC-associated risk factors have not been investigated. This study explored differences composition (total protein, DNA, mucin content, sialic acid, immunoregulatory...
Bacterial infection often causes clinical complications and failure of indwelling medical devices. This is a major problem current ureteral stents, which are used clinically to treat the blockage canals. study investigates effectiveness applicability magnesium as novel biodegradable stent material that has inherent antimicrobial properties. Incubating Escherichia coli with samples showed decrease in bacterial cell density compared currently commercial polyurethane stent. Magnesium...
Mucus constitutes a protective layer which coats the gastrointestinal tract, controlling interactions of both commensal and pathogenic microbes with underlying tissues. Changes to mucus barrier, for example due altered mucin expression or external stimuli, may impact thus potentially contribute gut homeostasis, onset inflammation, pathogen invasion. Food-associated including lipids, have been shown change barrier properties reduce transport model drug carriers through mucus. Here, we explore...
Gut-on-a-chip in vitro modeling is an emerging field, as the human gut epithelium and microbiome have been recently identified novel drug targets for a wide variety of diseases. Realistic models require precise environmental cues, such chemical gas gradients, combination with substrates like mucus that support growth microbial communities. This technical brief describes microfluidic architecture capable developing physiologically relevant oxygen gradient emulates profile proximal to...
Considerable effort has been put forth to understand mechanisms by which the microbiota modulates and responds inflammation. Here, we explored whether oxidation metabolites produced host during inflammation, sodium nitrate trimethylamine oxide, impact composition of a human stool bacterial population in gut simulator. We then assessed an immune-competent vitro intestinal model responded differently spent medium from bacteria exposed these cues compared control population. The host-derived...
Implant longevity is desired for all bone replacements and fixatives. Titanium (Ti) implants fail due to lack of juxtaposed formation, resulting in implant loosening. surface modifications have shown affect the interactions between bone. In clinical applications, it crucial improve osseointegration fixation at interface. Moreover, marrow derived cells play a significant role tissue integration. Therefore, objective this study investigate how micropatterning on Ti influences its with...
ABSTRACT Macrophages adopt dynamic cell states with distinct effector functions to maintain tissue homeostasis and respond environmental challenges. During chronic inflammation, macrophage polarization is subverted towards sustained inflammatory which contribute disease, but there limited understanding of the regulatory mechanisms underlying these disease-associated states. Here, we describe a systematic functional genomics approach that combines genome-wide phenotypic screening in primary...
Magnesium (Mg) alloys, a novel class of degradable, metallic biomaterials, have attracted growing interest as promising alternative for medical implant and device applications due to their advantageous mechanical biological properties. Moreover, magnesium is biodegradable in the physiological environments. The major obstacle Mg be used implants its rapid degradation fluids. Therefore, present key challenge lies controlling rate environment. objective this study develop...
Magnesium-based alloys are promising for various biomedical applications due to their advantageous mechanical and biological properties. In this study, we investigated the potential use of magnesium-based urological device applications, e.g. a biodegradable antibacterial ureteral stent. Previous studies showed that samples significantly inhibited bacterial growth colony formation in artificial urine (AU) solution as compared with polyurethane-based This current study focuses on long-term...
Current advancement in nanotechnology created novel solutions to improve drug delivery and enhance the efficacy of therapeutics for tissue regeneration disease treatment. Nanomaterials can be designed fabricated have biomimetic characteristics unique properties controlling cellular functions (e.g. cell adhesion stem differentiation) delivering more effectively. Different nanomaterials, including nanoparticles, nanofibers, nanospheres, nanocomposites, are highlighted with key examples vitro...