A5028363442- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Multiple Sclerosis Research Studies
- Immune Response and Inflammation
- Atherosclerosis and Cardiovascular Diseases
- RNA modifications and cancer
- Inflammasome and immune disorders
- Salivary Gland Disorders and Functions
- Cerebrospinal fluid and hydrocephalus
- Peripheral Neuropathies and Disorders
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
National and Kapodistrian University of Athens
2017-2022
Pasteur Hellenic Institute
2020
Abstract Background Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property p21 WAF1/Cip1 , showing that chronic expression in p53-deficient environment causes genomic by deregulation replication licensing machinery. Results We now demonstrate can further fuel suppressing repair capacity low- high-fidelity pathways deal...
Abstract Background Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential to design appropriate therapeutic strategies. In a recent study we reported an unexpected oncogenic property p21 WAF1/Cip1 showing that chronic expression, in p53-deficient environment, causes genomic by deregulating the replication licensing machinery. Results Extending on this work now demonstrate can further fuel suppressing repair capacity low high...
Several previous studies from our laboratory have indicated that the salivary gland epithelia of primary Sjögren's syndrome (SS) patients are not only target autoimmune immune responses, but also key instigators chronic inflammatory infiltrates patients.In particular, comparative analysis tissue specimens and in-vitro cultured non-neoplastic epithelial cell lines (SGEC, ductal type) SS-patients non-SS diseasecontrols, unequivocally highlighted presence intrinsic activation in aberrant...