A5057458741- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Lymphoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Bone health and osteoporosis research
- Bone health and treatments
- Chronic Lymphocytic Leukemia Research
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Monoclonal and Polyclonal Antibodies Research
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Sarcoma Diagnosis and Treatment
Ben-Gurion University of the Negev
2015-2025
Soroka Medical Center
2004-2024
University of California, Los Angeles
2006-2021
Roche (Switzerland)
2021
Gundersen Health System
2021
University of Oxford
2021
Kyoto University
2021
Oxford Health NHS Foundation Trust
2021
Warneford Hospital
2021
Massachusetts Institute of Technology
2017
Abstract The Recurrence Score® is increasingly used in node-positive ER+ HER2-negative breast cancer. This retrospective analysis of a prospectively designed registry evaluated treatments/outcomes cancer patients who were Score-tested through Clalit Health Services from 1/2006 12/2011 ( N = 709). Medical records reviewed to verify treatments/recurrences/survival. Median follow-up, 5.9 years; median age, 62 53.9% grade 2; 69.8% tumors ≤ 2 cm; 84.5% invasive ductal carcinoma; 42.0% N1mi, and...
The 21-gene Recurrence Score® (RS) assay is a validated prognostic/predictive tool in ER + early-stage breast cancer. However, clinical outcome data from prospective studies RS ≥ 11 patients are lacking, as relevant real-life practice data. In this retrospective analysis of prospectively designed registry, we evaluated treatments/clinical outcomes undergoing RS-testing through Clalit Health Services. included N0 HER2-negative cancer who were RS-tested 1/2006 12/2010. Medical records reviewed...
BackgroundWomen who carry germ-line mutations in BRCA1/2 are at very high risk of developing breast and ovarian cancer. Breast conserving therapy is associated with a similar ipsilateral cancer recurrence BRCA carriers compared non-carriers. However, the subsequent contralateral markedly increased. Therefore, mastectomy diseased along reducing often advocated for treated early Yet, many forgo this option fear harmful effects choose treatment observation instead. In Israel, BRCA-associated...
The 21-gene recurrence score (RS) assay has been reported to accurately predict the risk of disease and chemotherapy benefit in women with estrogen receptor (ER)-positive, lymph node (LN)-negative breast cancer who are treated tamoxifen. To authors' knowledge, association between RS clinicopathologic characteristics studied randomized case-control trials, but not general population.The authors analyzed correlation among 300 consecutive Israeli patients were referred undergo test October 2004...
The 21-gene recurrence score (RS) assay has been widely adopted for use in early estrogen receptor (ER)-positive breast cancer to assess the risk distant and potential benefit of adjuvant chemotherapy. primary aim this study was RS distribution Israeli male (MBC) patients.The population included 65 newly diagnosed MBC patients. Clinical pathologic data were collected at time referral. Pathologic examinations conducted pathology departments referring centers. (Oncotype DX™) performed on...
Oncotype DX testing is reimbursed in Israel for node-negative and node-positive (N1+; up to 3 positive nodes including micrometastases), estrogen receptor (ER+), breast cancer patients. This retrospective study evaluated the impact of on treatment decisions N1+/ER+ To this end, we compared treatments all N+ patients whom had been ordered with similar characteristics where test not available. The analysis included 951 (282 DX, 669 controls), received endocrine therapy or without chemotherapy....
Post-traumatic stress disorder (PTSD) has not been examined systematically in long-term survivors of lymphoma. In this study, PTSD and health related quality life (HRQoL) were assessed 44 patients with Hodgkin's disease <formula>(<italic>n</italic>=8)</formula> or non-Hodgkin's lymphoma <formula>(<italic>n</italic>=36).</formula> Forty-four individuals who had experienced traumatic events as defined by the Diagnostic Statistical Manual-IV (DSM-IV) possible triggers for served controls. The...
The 21-gene Recurrence Score (RS) assay is a validated prognosticator/predictor of chemotherapy (CT) benefit in early-stage estrogen receptor (ER)-positive breast cancer (BC). Long-term data from real-life clinical practice where treatment was guided by the RS result are lacking. We performed exploratory analysis Clalit Health Services (CHS) registry, which included all CHS patients with node-negative ER+ HER2-negative BC who underwent testing between 1/2006 and 12/2009 to determine 10-year...
This nonrandomized phase 2 clinical trial examines contralateral breast cancer risk reduction in women who choose radiation therapy or surveillance rather than mastectomy.
Previous studies have suggested an inverse relationship between bone mineral density (BMD) and breast cancer incidence. The primary objective of this study was to assess whether BMD is associated with risk subsequent occurrence in the female population southern Israel.The electronic medical charts women who underwent at Soroka Medical Center (SMC) February 2003 March 2011 were screened for diagnoses. Women divided by tertiles 3 skeletal sites: lumbar spine (LS, L1-4), total hip (TH) femoral...
<b><i>Background:</i></b> Recent studies have shown that the peripheral blood pretreatment neutrophil/lymphocyte ratio (NLR) is a prognostic measure in various cancers. The few evaluating NLR glioblastoma multiforme (GBM) patients yielded inconsistent results. <b><i>Objectives:</i></b> primary objective of our study was to test ability predict overall survival (OS) and progression-free (PFS) with GBM treated by combined modality therapy...
Estrogen may have opposing effects on health, namely increasing the risk of breast cancer and improving bone health by mineral density (BMD). The objective this study was to compare dual-energy X-ray absorptiometry (DXA) BMD between women newly diagnosed with matched controls without cancer. Women treated April 2012 October 2017 were prospectively enrolled. A control group established negative mammography or ultrasound, 1:1 age, body mass index, parity, use hormone replacement therapy. All...
Background. Primary true isolated metastasis in a peripheral nerve trunk is considered rare phenomenon. Several routes of tumor invasion the nervous system from different types cancer and various anatomic locations have been described literature; however, brachial plexus an uncommon site such blood-born metastases. Methods. Five patients with severe neuropathy without obvious external signs masses no detectable regional lymph node involvement underwent exploration plexus. Results. Isolated...
<i>Objective:</i> This study reports the efficacy and safety of zoledronic acid (ZOL) in preventing bone loss postmenopausal patients receiving an aromatase inhibitor (AI) following tamoxifen. <i>Methods:</i> Postmenopausal with stage I–III hormone receptor-positive breast cancer who received tamoxifen for 2.5–3 years were randomized to receive letrozole (2.5 mg/day) (n = 47) or without 43) ZOL (4 mg i.v. every 6 months) 2 years. The primary endpoint was percent...
Although only some medical students pursue a career in oncology, all should have basic understanding of the issues surrounding cancer and its treatment. The authors designed implemented one-week introductory clinical oncology course for second-year at Ben Gurion University Negev. presents holistic approach to caring patients with that goes beyond biological aspects disease.In 2013, interviewed four former surveyed current before after they completed evaluate reception effectiveness.Of 86...
Studies of cognitive effects chemotherapy among breast cancer patients show that not all women who are exposed to develop dysfunction and the observed declines in functioning may be quite subtle. The use measures sensitive subtle decline recommended yet rarely used clinical populations. purpose this study is specify types memory changes survivors treated with tamoxifen, by using an analytic test memory, Doors People test, which uses age-adjusted norms. participants were 40 cancer, 20 whom...
Molecular tools have increasingly been used for decision-making in patients with early breast cancer (EBC). Nevertheless, simple such as immunohistochemistry may still be required particular cases to complement traditional and molecular prognosticators. In this study, the prognostic significance of three well-known immunohistochemical biomarkers, cathepsin D, E-cadherin Ki67, was studied 270 EBC, followed by a median time 126 months single institution. Histological examination performed...
Background: Breast cancer (BC) is the most frequent type, and leading cause of death from among women in Israel. The Bedouin-Arab (BA) population southern Israel characterized by a high rate consanguinity, common hereditary disorders, transition semi-nomadic, traditional society to more sedentary urbanized society. In this hospital-based study, demographic clinicopathological characteristics BC BA were compared with Jewish patients. Materials Methods: 85 patients treated at Soroka Medical...
Abstract Background: An association between higher bone mineral density (BMD) and the diagnosis of breast cancer (BC) has been reported. Data on risk osteoporotic fractures in women with BC are conflicting. Aims: The objective this study was to assess fracture adjusted for BMD without BC, whether patients is attributed or characteristics. Methods: Using electronic medical records who underwent dual energy X-ray absorptiometry studies at Soroka University Medical Center February 2003 March...