Nisin is a lantibiotic widely used for the preservation of food and beverages. Recently, investigators have reported that nisin may clinical applications treating bacterial infections. The aim this study was to investigate effects ultra pure grade ZP (>95% purity) on taxonomically diverse bacteria common human oral cavity saliva derived multi-species biofilms, discern toxicity against cells relevant cavity.The minimum inhibitory concentrations bactericidal distinct were determined using agar...

Epidemiological studies reveal significant associations between periodontitis and oral cancer. However, knowledge about the contribution of periodontal pathogens to cancer potential regulatory mechanisms involved is limited. Previously, we showed that nisin, a bacteriocin commonly used food preservative, reduced tumorigenesis extended life expectancy in tumor-bearing mice. In addition, nisin has antimicrobial effects on key pathogens. Thus, purpose this study was test hypothesis...

Given the potential relationship between head and neck squamous cell carcinoma (HNSCC) microbial dysbiosis, we profiled microbiome within healthy normal tumorous (primary metastatic) human tissues from oral cavity, larynx-pharynx, lymph nodes using 16S rRNA sequencing. Alpha beta diversity analyses revealed that had greatest richness in community diversity, while metastatic populations were most closely related to one another. Compared normal, microbiota associated with tumors supported...

Abstract CD 44, an extracellular matrix ( ECM ) receptor, has been described as a cancer stem cell marker in multiple cancers, including head and neck squamous carcinoma HNSCC ). orasphere formation or stemness was characterized by cleavage of thus we hypothesized that this proteolytic processing may be critical to tumorigenesis. We tested hypothesis examining the mechanisms regulate process vitro vivo, exploring its clinical relevance human specimens. Sphere assays have used evaluate vitro....

Oral pathogens, including Treponema denticola, initiate the dysregulation of tissue homeostasis that characterizes periodontitis. However, progress research on roles T. denticola in microbe-host interactions and signaling, microbial communities, physiology, molecular evolution has been hampered by limitations genetic methodologies. This is typified an extremely low transformation efficiency inability to transform most widely studied strain with shuttle plasmids. Previous studies have...

This paper describes a high-throughput method that relies upon microplate reader to score coaggregation 60 min postmixing, and use of high-speed real-time imaging technology describe the rate over time. The results visual, microplate, FlowCam(™) aggregation scores for oral bacteria Streptococcus gordonii, oralis, Actinomyces oris, whose ability coaggregate are well characterized, compared. Following mixing all possible pairs, top fraction supernatant was added quantify cell-density. Pairs...

The cutaneous myiasis has been rarely reported in the Republic of Korea. We intended to describe here a case furuncular caused by Cordylobia anthropophaga larvae Korean traveler returned from Central Africa. A patient, 55-year-old man, had traveled Equatorial Guinea, Africa for month and just Physical examinations showed 2 tender erythematous nodules with small central ulceration on left buttock thigh. During skin biopsy, came out lesion. C. was identified paired mouth hooks (toothed,...

본 연구는 시중 유통되고 있는 곡류가공품 중 zearalenone을 immunoaffinity column 및 LC-MS/MS를 이용해 분석하였다. 표준용액의 검량선은 1, 10, 50, 100, 250 ng/mL농도 범위에서 상관계수(<TEX>$r^2$</TEX>) 0.999 이상으로 양호한 직선성을 보였고, 검출한계 정량한계는 각각 0.3, <TEX>$1.0{\mu}g/kg$</TEX>이었다. 회수율은 77.2-107.8%였고, RSD는 1.5-12.8이었다. Product ion 283 m/z으로 정량하여 분석한 결과 과자류 21건 1건(4.8%) <TEX>$2.3{\mu}g/kg$</TEX>, 옥수수가공품 9건 2건(22.2%) <TEX>$1.6-8.5{\mu}g/kg$</TEX>, 기타곡류가공품 14건 선식 1건(7.1%)에서 <TEX>$3.4{\mu}g/kg$</TEX>이 검출되었다. 미숫가루가 19건 6건(31.6%)이 검출되어, 최고 검출율을 나타냈으며,...

Abstract Periodontitis is a chronic infectious disease characterized by inflammation and destruction of periodontal tissues including the ligament fibers alveolar bone. Recent epidemiological studies have revealed significant association between periodontitis oral cancer. While precise mechanisms that mediate these associations are not well understood, pathogens, Treponema denticola (T. denticola), which believed to initiate destructive inflammatory responses dysbiosis or dysregulation...

The objective of this research was to compare the coordination patterns trunk and arm in Nordic normal walking. 9 healthy male subjects have participated two different walking on treadmill. Kinematic variables pelvis, thorax, total arm, upper, lower were analyzed by cinematography with 8 infrared cameras. approached concept passive mass-damping system which is used transfer energy from extremities pelvis thorax affects swing sagittal plane. There no significant difference correlation torsion...

The purpose of this study was to analyse the effect suppressing arm swing and walking speed on individual motion inter-segmental coupling thigh, pelvis, thorax in human walking. subjects were selected 10 healthy college male students 6 infra cameras used for cinematograph. Walking speeds determined with slow(2.8km/h), medium(3.6km/h) fast(5.2km/h) walking(SASW) normal walking(NW) treadmill. There significant difference stride length speeds, feature is that increased increasing speed....

Abstract The poly(2‐hydroxyethyl methacrylate) (PHEMA) is a disubstituted vinyl chain in which the substituents CO 2 CH OH and 3 differ size shape. In order to verify various characteristics of PHEMA chain, conformational energy calculations for meso racemic diads, are segments consisting stereoregular isotactic syndiotactic chains, respectively, were carried out using ECEPP/2 potential. From these calculations, averaged geometry statistical weights obtained local minima. characteristic...

The objective of this research was to analyze the relative phase trunk in changes walking speed and two different patterns. This study examined energy normal three velocities with healthy 10 males while on a treadmill. range motion for thorax pelvis were calculated. There no difference patterns, but significantly decreased speed. patterns changes. Continuous phase(CRP) more out-of-phase variability CRP not greater as increasing Discrete respectively. As result, stride cycles magnitude...

The purpose of this research was to analyze the feature stride duration and trunk counter movement at preferred walking speed in walking. Subjects were selected 9 healthy college male students 6 infra cameras used for cinematograph. speeds determined 80, 90, 100, 110, 120% speed. variables mainly associated with strides movements. Stride variable counter-movement RoM, CRP(continuous relative phase) correlation trunk. magnitude variability which explained by standard deviation or coefficient...