A5060685529- Mitochondrial Function and Pathology
- Fuel Cells and Related Materials
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Extracellular vesicles in disease
- ATP Synthase and ATPases Research
- Pluripotent Stem Cells Research
- Digestive system and related health
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Polymer Surface Interaction Studies
- Cardiovascular Disease and Adiposity
- Biomedical Ethics and Regulation
- Viral Infections and Immunology Research
- Myasthenia Gravis and Thymoma
- Tissue Engineering and Regenerative Medicine
- Eicosanoids and Hypertension Pharmacology
- Renal and related cancers
- Inflammatory mediators and NSAID effects
- Adipose Tissue and Metabolism
- Cancer-related gene regulation
- Synthesis and biological activity
- Pituitary Gland Disorders and Treatments
- Integrated Circuits and Semiconductor Failure Analysis
- Congenital heart defects research
University of Gothenburg
2024
Lund University
2023
University of Alabama at Birmingham
2019
Instituto Politécnico Nacional
2018
Center for Research and Advanced Studies of the National Polytechnic Institute
2014-2018
RNA-binding proteins like human antigen R (HuR) are key regulators in post-transcriptional control of gene expression several pathophysiological conditions. Diabetes adversely affects monocyte/macrophage biology and function. It is not known whether diabetic milieu cellular/exosome-HuR its implications on cardiac inflammation fibrosis. Here, we evaluate vitro vivo effects macrophage cellular/exosome-HuR, alterations intercellular cross talk with fibroblasts, impact remodeling. Human failing...
Obg-like ATPase 1 (OLA1) that possesses both GTP and ATP hydrolyzing activities has been shown to be involved in translational regulation of cancer cell growth survival. Also, GSK3β signalling implicated cardiac development disease. However, the role OLA1 pathological hypertrophy is unknown. We sought understand mechanism by which regulates GSK3β-β-Catenin its functional significance angiotensin-II (ANG II)-induced hypertrophic response. function endogenous interaction with GSK3β/β-catenin...
Background There is an unmet clinical need for novel therapies addressing the residual risk in patients receiving guideline preventive therapy coronary heart disease. Experimental studies have identified a pro-atherogenic role of oxidized LDL receptor LOX-1. We investigated association between circulating soluble LOX-1 (sLOX-1) and development myocardial infarction.
The effects of diazoxide on cardiac hypertrophy and miR-132 expression were characterized in adult rats cardiomyocytes. Diazoxide reactive oxygen species (ROS) production the cAMP-response element binding (CREB) transcription factor's abundance cardiomyocytes also analyzed. ROS measurements used a fluorescent dye. Western blot analysis quantitative Reverse Transcription Polymerase Chain Reaction to measure phosphorylated form CREB (pCREB) expression, respectively.Isoproterenol (ISO) induced...
Polymeric nanoparticles like chitosan may be used to deliver drugs particular organs, such as heart. However, due the lack of information about acute effects in cardiac calcium handling, we evaluated same intact rat left ventricular myocytes. Chitosan were synthesized by ionic gelation method for three different concentrations and tripolyphosphate (TPP) 1:1, 2:1 3:1, respectively. The size particles was below 100 nm 3:1 chitosan:TPP ratio 300 1:1 ratio. incubated 0, 15, 30 60 minutes with...
Abstract Background and Aims Mesangial cells their matrix form the central stalk of glomerulus but is often overlooked when studying glomerular function. The are however highly involved in function crosstalk between different cell types glomerulus. They important onset progression several diseases, such as IgA nephropathy diabetic kidney disease. As mesangial have functions disease they used for vitro work response to various stimuli downstream signaling. This includes changes production...
Abstract Background and Aims IgA nephropathy (IgAN) is an autoimmune disease characterized by deposits that build up in the kidneys, inflame damage glomeruli causing hematuria proteinuria. It a leading cause of chronic kidney disease, which often results end-stage disease. There no specific treatment for IgAN. The glomerulus, IgA1 lacking galactose residues (gdIgA1) are deposited, consists mesangial cells, podocytes, endothelial cells. Crosstalk between cell types allows glomerulus to act as...
Background: OLA1 that possesses both GTP and ATP hydrolyzing activities has been reported as a translational regulator of cell growth survival. However, its role in cardiac hypertrophy, process involving enhanced protein synthesis increased size not studied. Hence, we hypothesized expression is regulated by oxidative stress inflammatory responses angiotensin-II induced hypertrophy aberrant mediates altered GSK3β-β-Catenin signaling. Methods: Protein OLA1, GSK3β/P-GSK3β, β-Catenin/P-β-Catenin...