A5027751574- Connexins and lens biology
- Corneal surgery and disorders
- Urinary Bladder and Prostate Research
- Ophthalmology and Visual Impairment Studies
- Heat shock proteins research
- Glaucoma and retinal disorders
- Thermoregulation and physiological responses
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Neurofibromatosis and Schwannoma Cases
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Cardiac electrophysiology and arrhythmias
- Retinal Diseases and Treatments
- Phonocardiography and Auscultation Techniques
- Ocular and Laser Science Research
- Cardiovascular Disease and Adiposity
- Intraocular Surgery and Lenses
- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Meningioma and schwannoma management
- Ocular Surface and Contact Lens
- Spectroscopy Techniques in Biomedical and Chemical Research
- ECG Monitoring and Analysis
- Ocular Oncology and Treatments
University of Auckland
2015-2024
Magnetic resonance imaging (MRI) has demonstrated high levels of tissue contrast, accuracy and reproducibility in evaluating posterior uveal melanoma. Owing to smaller size, the role MRI detecting characterising iris melanoma not yet been explored. Aims: To develop a protocol image describe characteristics histopathological-confirmed An optimised protocol, using 3 T scanner 32-channel head coil, was developed tumours. A prospective, single-centre, 12-month study conducted on all patients...
The purpose of this study was to utilize in vivo magnetic resonance imaging (MRI) and optical modeling investigate how changes water transport, lens curvature, gradient refractive index (GRIN) alter the power mouse as a function age.
We have developed and validated in vivo magnetic resonance imaging (MRI) protocols to extract parameters (T2 geometry) of the human lens that, combined with biometric measures eye optical modelling, enable us investigate relative contributions made by gradient refractive index (GRIN) shape properties each subject tested. Seven young healthy participants (mean age: 25.6 ± 3.6 years) underwent an ophthalmic examination, two sessions MRI scans using a 3 T clinical magnet. Our for studying...
To investigate whether a redistribution of water within the crystalline lens is associated with shape deformation that occurs during accommodation.
Purpose: To use magnetic resonance imaging (MRI) to measure age-dependent changes in total and free water human lenses vivo. Methods: Sixty-four healthy adults aged 18 86 years were recruited, fitted with a 32-channel head receiver coil, placed 3 Tesla clinical MR scanner. Scans of the crystalline lens obtained using volumetric interpolated breath-hold examination sequence dual flip angles, which corrected for field inhomogeneity post-acquisition B1-map turbo-FLASH sequence. The spatial...
To optimize our in vivo magnetic resonance imaging (MRI)-based optical model of the human crystalline lens, developed with a small group young adults, for larger cohort spanning wider age range.Subjective refraction and ocular biometry were measured 57 healthy adults ages 18 to 86 years who then scanned using 3T clinical (MRI) obtain lens gradient refractive index (GRIN) geometry measurements. These parameters combined biometric measurements construct individualized Zemax eye models from...
Gastric motility is coordinated by bio-electrical events known as slow waves. Abnormalities in waves are linked to major functional and disorders. In recent years, the use of high-resolution (HR) recordings have provided a unique view spatiotemporal activation profiles normal dysrhythmic wave activity. To date, vivo studies gastric activity primarily focused on phase event. this study, recovery was investigated through HR recording techniques. The event detected signal derivative, computed...
Purpose: The purpose of this study was to utilize multi-parametric magnetic resonance imaging (MRI) investigate in vivo age-related changes the physiology and optics mouse lenses where Connexin 50 has been deleted (Cx50KO) or replaced by 46 (Cx50KI46). Methods: transgenic Cx50KO Cx50KI46 mice were imaged between 3 weeks 6 months age using a 7T MRI. Measurements lens geometry, T2 (water-bound protein ratios), refractive index (n), T1 (free water content) values calculated processing acquired...
In the absence of a blood supply lens operates an internal microcirculation to deliver nutrients, remove metabolic wastes, and controll volume, which together maintain optical properties lens. While this is generated by circulating fluxes ions water, visualising water flow throughout whole especially into central in real time has proven challenging. To address this, we developed optimised new deuterium oxide (D2O) MRI protocols image within multiple organ-cultured bovine lenses that can be...
The vitreous humour is a clear, gel-like fluid to provide structural support the eye. Recently, it has been shown that important in regulating oxygen levels within back of However, with ageing, undergoes liquefaction, and as result, able be move more freely throughout vitreous, which increases exposure tissues such lens oxygen. In this study, we developed MRI-based protocols clinically monitor viscosity applied these protocol cohort elderly partipants.