A5033502189- Ultrasound and Hyperthermia Applications
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- Growth Hormone and Insulin-like Growth Factors
- Microgrid Control and Optimization
- Multilevel Inverters and Converters
- Birth, Development, and Health
- Genetics, Aging, and Longevity in Model Organisms
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Epigenetics and DNA Methylation
- Photovoltaic System Optimization Techniques
- Photoacoustic and Ultrasonic Imaging
- Advanced Drug Delivery Systems
- Corneal Surgery and Treatments
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Spectroscopy Techniques in Biomedical and Chemical Research
- Carcinogens and Genotoxicity Assessment
- Ultrasound and Cavitation Phenomena
- Hydrogels: synthesis, properties, applications
- Sirtuins and Resveratrol in Medicine
- Ocular Infections and Treatments
- Advancements in Transdermal Drug Delivery
- Retinal Development and Disorders
University of Auckland
2017-2025
Chandigarh University
2017-2024
Sharda University
2024
Boston VA Research Institute
2019-2023
Harvard University
2019-2023
Manubhai Patel Dental College and Hospital
2022
The University of Queensland
2014-2019
The University of Texas Health Science Center at San Antonio
2011-2015
The University of Texas Health Science Center at Houston
2015
National Center for Disease Control
2009-2011
Physicochemical properties of nanoparticles, such as size, shape, surface charge, density, and porosity play a central role in biological interactions hence accurate determination these characteristics is utmost importance. Here we propose tunable resistive pulse sensing for simultaneous size charge measurements on particle-by-particle basis, enabling the analysis wide spectrum nanoparticles their mixtures. Existing methodologies measuring zeta potential using are significantly improved by...
Reactive oxygen species (ROS) generated by Nox NADPH oxidases may play a critical role in the pathogenesis of diabetic nephropathy (DN). The efficacy Nox1/Nox4 inhibitor GKT137831 on manifestations DN was studied OVE26 mice, model type 1 diabetes. Starting at 4–5 mo age, mice were treated with 10 or 40 mg/kg, once-a-day for 4 wk. At both doses, inhibited oxidase activity, superoxide generation, and hydrogen peroxide production renal cortex from without affecting Nox1 Nox4 protein expression....
Mutations in insulin/IGF-1 signaling pathway have been shown to lead increased longevity various invertebrate models. Therefore, the effect of haplo- insufficiency IGF-1 receptor (Igf1r+/−) on longevity/aging was evaluated C57Bl/6 mice using rigorous criteria where lifespan and end-of-life pathology were measured under optimal husbandry conditions large sample sizes. Igf1r+/− exhibited reductions levels activation Akt by IGF-1, with no compensatory increases serum or tissue mRNA levels,...
Ultrasound enhances drug delivery into the central nervous system (CNS) by opening barriers between blood and CNS triggering release of drugs from carriers. A key challenge in translating setups vitro to vivo settings is achieving equivalent acoustic energy delivery. Multiple devices have now been demonstrated focus ultrasound brain, with concepts emerging also target spinal cord. Clinical trials date used facilitate blood–brain barrier. While most focused on feasibility safety...
Poloxamer hydrogels are of interest as injectable depot delivery systems. However, their use for delivering hydrophobic drugs, such curcumin, is limited due to poor loading capacity. Here, we evaluated the influence incorporating medium chain triglycerides (MCT) or amphiphilic polyethylene glycol 400 (PEG400) on physicochemical properties, drug loading, and in vitro compatibility a curcumin-loaded poloxamer hydrogel. 407 188 hydrogel formulations (16:6 w/w) were prepared MCT PEG400...
Glutathione (GSH) is a tripeptide with potent antioxidant activity, which involved in numerous basic biological processes and has been used for interventions various degenerative diseases. However, oral delivery of GSH remains challenging, similarly to that other protein peptide drugs, because the physicochemical barriers gastrointestinal (GI) tract lead low bioavailability. Although several approaches have explored improve delivery, such as co-administration penetration enhancers enzymatic...
The use of sunscreen products is widely promoted by schools, government agencies, and health-related organizations to minimize sunburn skin damage. In this study, we developed stable solid lipid nanoparticles (SLNs) containing the chemical UV filter octyl methoxycinnamate (OMC). parallel, produced similar SLNs in which 20% OMC content was replaced botanical urucum oil. When these were applied human volunteers, no changes fluorescence lifetimes or redox ratios endogenous fluorophores seen,...
Herein we showcase the potential of ultrasound-responsive nanobubbles in enhancing macromolecular permeation through layers retina, ultimately leading to significant and direct intracellular delivery; this being effectively demonstrated across three relevant distinct retinal cell lines. Stably engineered a highly homogenous echogenic nature were fully characterised using dynamic light scattering, B-scan ultrasound transmission electron microscopy (TEM). The appeared as spherical...
IntroductionIschemic gut injury is common in the intensive care unit, impairs barrier function, and contributes to multiorgan dysfunction. One novel intervention mitigate ischemic direct luminal delivery of oxygen microbubbles (OMB). Formulations OMB can be modified control rate delivery. This project examined whether pectin-modified (OMBp5) reduce a rodent model.MethodsThe OMBp5 formulation was adapted improve along length small intestine. Adult Sprague–Dawley rats (n = 24) were randomly...