A5009620650- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Career Development and Diversity
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant Molecular Biology Research
- Neurotransmitter Receptor Influence on Behavior
- Interdisciplinary Research and Collaboration
- Neuropeptides and Animal Physiology
- Photosynthetic Processes and Mechanisms
- Olfactory and Sensory Function Studies
- Engineering Education and Pedagogy
- Glycosylation and Glycoproteins Research
- Protein purification and stability
- Plant biochemistry and biosynthesis
- Signaling Pathways in Disease
- Ion channel regulation and function
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Innovative Teaching Methods
- RNA Interference and Gene Delivery
- Neuroscience, Education and Cognitive Function
The University of Texas at San Antonio
2000-2024
The dorsal CA3 region of the hippocampus is unique in its connectivity, sensitivity to neurotoxic lesions, and ability encode retrieve episodic memories. Computational models predict that blocking mossy-fiber and/or perforant path activity would cause impairments learning recall spatial memory, respectively. Because contains μ-opioid receptors receives inputs from lateral pathways, both which contain release opioid peptides, we tested hypothesis inactivating memory retrieval deficits. In...
Abstract The effects of aging on long‐term potentiation (LTP) in the dentate gyrus (DG) and CA1 are well documented, but LTP at medial perforant path (MPP)‐CA3 synapse aged animals has remained unexplored. Because MPP‐DG Schaffer‐collateral‐CA1 synapses account for only about 20% total hippocampal synapses, global understanding how affects plasticity limited. Much is known induction formation, whereas mechanisms that regulate maintenance less understood, especially during aging. We...
Protein synthesis inhibitors block the maintenance of NMDA receptor-dependent long-term potentiation (LTP) both in vivo and vitro . mossy fiber(MF) LTP , but little is known about effect protein on either induction or MF-LTP Here we study role at fiber–CA3 hippocampal synapse anesthetized rats. The inhibitor anisomycin was administered different doses (0.04, 10, 40 nmol) into area CA3 15 min before delivering high-frequency stimulation (two times 100 Hz, 1 sec). Anisomycin blocked a...
Abstract Aging is associated with a decreased capacity for dentate gyrus (DG) granule cell depolarization as well reduced perforant path activation. Although it established that the maintenance of DG long‐term potentiation (LTP) over days impaired in aged, compared to young animals, threshold inducing this LTP has never been investigated awake animals. In addition, although exposure novelty prior θ‐burst stimulation (TBS) increases both induction and longevity adult rats, effects on aged...
Abstract During muscle development, the p75 NTR is expressed transiently on myoblasts. The temporal expression pattern of receptor raises possibility that influencing development. To test this hypothesis, ‐deficient mutant mice were tested for strength by using a standard wire gripe and found to have significantly decreased relative normal mice. When mybolasts examined in vivo NGF receptors, was detected myoblasts but high affinity receptor, trk A, not co‐expressed with . In vitro,...
A functional hippocampus is required for trace fear conditioning, which involves learning the association of a tone and shock that are separated over time. Young aged rats received 10 conditioning trials. Twenty-four hours later, were tested to in novel chamber by measuring freezing. The results showed significantly lower levels freezing as compared with young rats, provides evidence age-related memory impairments. Pseudorandom groups low freezing, indicative no associative memory....
ABSTRACT The Partnership for Undergraduate Life Sciences Education (PULSE) is a non-profit educational organization committed to promoting the transformation of undergraduate STEM education by supporting departments in removing barriers access, equity, and inclusion adopting evidence-based teaching learning practices. PULSE Ambassadors Campus Workshop program enables faculty staff members host 1) develop communication, shared leadership, skills effective team learning; 2) implement...
Metabotropic glutamate receptors (mGluR) are implicated in long-term memory storage. mGluR-I and mGluR-II antagonists impede various forms of learning potentiation (LTP) animals. Despite the evidence linking mGluR to mechanisms, their role mossy fiber-CA3 is not yet clear. To explain involvement we examined function antagonist 1-aminoindan-1, 5-dicarboxylic acid (AIDA) on induction LTP vivo male Sprague Dawley Fischer 344 (F344) rats. Acute extracellular fiber (MF) responses were evoked by...
A 2-D native-PAGE/SDS-PAGE method for detecting the subunit components of protein oligomers at low picomole sensitivity is presented. IgG was electrophoresed in a native acidic polyacrylamide gel amounts ranging from 51 pmol to 60 fmol. Silver-staining (native fast silver stain, ammoniacal permanganate stain), Coomassie-staining (R-250, G-250), metal ion-reverse-staining (zinc, copper), and fluorescent chromophore-staining (SYPRO Ruby) methods were used visualize oligomers. The zones then...
The nucleus accumbens (NAcb), a basal forebrain structure implicated in drug-mediated reward, receives afferents from variety of limbic and cortical structures, including the prefrontal cortex, amygdala, entorhinal subicular complex. In present study, monosynaptic projections lateral cortex (lateral perforant path) to NAcb are shown display sustained increases field EPSP magnitudes following high-frequency stimulation path anesthetized rats. By contrast, medial aspect path, although capable...