A5081751177- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Economic and Financial Impacts of Cancer
- Orthopaedic implants and arthroplasty
- Statistical Methods in Clinical Trials
- Liver Disease Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- demographic modeling and climate adaptation
- Wind Energy Research and Development
- Bone fractures and treatments
- Lung Cancer Diagnosis and Treatment
- Insurance, Mortality, Demography, Risk Management
- Healthcare Policy and Management
- Maternal and Perinatal Health Interventions
- Statistical Methods and Inference
- Total Knee Arthroplasty Outcomes
- Wind and Air Flow Studies
- Opioid Use Disorder Treatment
- Posttraumatic Stress Disorder Research
- Airway Management and Intubation Techniques
- Tuberous Sclerosis Complex Research
- Innovation Policy and R&D
- Aerodynamics and Fluid Dynamics Research
- Urinary and Genital Oncology Studies
- Stress Responses and Cortisol
University of Warwick
2017-2025
University of Birmingham
2025
Senergy (United Kingdom)
2016
Wind power generation is growing fast as one of the most promising renewable energy sources that can serve an alternative to fossil fuel-generated electricity. When wind turbine generator (WTG) extracts from wind, wake evolves and leads a considerable reduction in efficiency actual generation. Furthermore, effect lead increase turbulence induced fatigue loads reduce life time WTGs. In this work, pulsed coherent Doppler lidar (PCDL) has been developed deployed visualize wakes characterize...
An analytical wind turbine wake model is proposed to predict the velocity distribution for all distances downwind of a turbine, including near-wake. This augments Jensen and subsequent derivations thereof, direct generalization that recently by Bastankhah Porté-Agel. The derived applying conservation mass momentum in context actuator disk theory, assuming double-Gaussian type deficit wake. physical solutions are obtained appropriate mixing waked- freestream solutions, reflecting fact only...
Extrapolations of parametric survival models fitted to censored data are routinely used in the assessment health technologies estimate mean survival, particularly diseases that potentially reduce life expectancy patients. Akaike’s information criterion (AIC) and Bayesian (BIC) commonly technology alongside an plausibility determine which statistical model best fits should be for prediction long-term treatment effects. We compare fit estimates restricted time (RMST) from 8 contrast preferred...
Background: Computer navigation and patient-specific instrumentation have been in use over the past 2 decades for total knee replacement (TKR). However, their effects on implant survival patient-reported outcomes remain under debate. We aimed to investigate influence survival, of Oxford Knee Score (OKS) health-related quality life (EQ-5D-3L), intraoperative complications, postoperative mortality compared with conventional instrumentation, across a real-world population. Methods: This...
Prehospital recognition of sepsis may inform case management by ambulance clinicians, as well transport decisions. The objective this study was to develop a prehospital screening tool for use clinicians. We derived and validated tool, utilising univariable logistic regression models identify predictors inclusion, multivariable generate the SEPSIS score. utilised retrospective cohort adult patients transported (n = 38483) hospital between 01 July 2013 30 June 2014. Records were linked using...
In this article, we present a simple-to-use framework for assessing the agreement of cost-effectiveness endpoints generated from different sources data. The aim package is to enable rapid assessment routine data use in analyses. By quantifying comparability with “gold-standard” trial data, inform decisions on suitability analysis. identification informative will increase opportunity economic analyses and potentially reduce cost burden collecting patient-reported clinical trials.
Previous work examined the suitability of relying on routine methods model selection when extrapolating survival data in a health technology appraisal setting. Here we explore solutions to improve reliability restricted mean time (RMST) estimates from trial by assessing plausibility and implementing averaging. We compare our previous selecting for extrapolation using Akaike information criterion (AIC) Bayesian (BIC). Our averaging include equal weighting across models falling within...
Tuberous sclerosis (TSC) is an inherited tumor syndrome caused by mutations in TSC1 or TSC2 that lead to aberrant activation of mTOR and development tumors multiple organs including the kidneys. The inhibitors rapamycin everolimus (rapalogs) have demonstrated clinical efficacy treating TSC-associated renal angiomyolipomas. However, responses are usually only partial, regrowth occurs after drug withdrawal. highly vascular, TSC patients with angiomyolipomas elevated levels circulating vascular...
Approximately 9% of a trauma surgeon's workload in the UK is managing ankle fractures. Following an fracture immobilisation with plaster cast or removable orthotic usual. The aim this research was to assess feasibility large multi-centre randomised controlled trial (RCT) evaluate difference between and for management adults fracture. A undertaken hospital which treating clinician would consider reasonable option. Exclusions included open pathological fracture, unable adhere procedures, had...
Economic evaluations conducted alongside randomized controlled trials are a popular vehicle for generating high-quality evidence on the incremental cost-effectiveness of competing health care interventions. Typically, in these studies, resource use (and by extension, economic costs) and clinical (or preference-based health) outcomes data collected prospectively trial participants to estimate joint distribution costs benefits associated with intervention. In this article, we extend...
Introduction: Disproportionate emphasis has been attributed to hip fracture over other femoral fractures through implementation of Best Practice Tariff (BPT). This retrospective comparative observational cohort study aimed evaluate the epidemiology native and periprosthetic establish any disparities in their management relative fractures. Methods: All patients ⩾60 years admitted with a or during July 2016–June 2018 were identified using our hospital database. Results compared National Hip...