A5069821655- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Metabolomics and Mass Spectrometry Studies
- Analytical chemistry methods development
- Pesticide Residue Analysis and Safety
- Advanced Chemical Sensor Technologies
- Pharmacological Effects and Assays
- Microfluidic and Bio-sensing Technologies
- Advanced biosensing and bioanalysis techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrochemical Analysis and Applications
- Traditional Chinese Medicine Analysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Electrowetting and Microfluidic Technologies
- Plasmonic and Surface Plasmon Research
- Biosensors and Analytical Detection
- Advanced Fluorescence Microscopy Techniques
- Advanced Proteomics Techniques and Applications
- Pharmacological Effects of Natural Compounds
- Microbial Metabolism and Applications
- Chemical Synthesis and Analysis
- Drug Transport and Resistance Mechanisms
- Phytochemistry and Biological Activities
- 3D Printing in Biomedical Research
Heilongjiang University of Chinese Medicine
2014-2025
Inner Mongolia Normal University
2024
Inner Mongolia University
2024
Sciex (Canada)
2020-2024
Wuhan University of Technology
2024
First Affiliated Hospital of Zhengzhou University
2023-2024
National Renewable Energy Laboratory
2024
Generic Robotics (United Kingdom)
2024
Tianjin University of Science and Technology
2024
Jiangsu University
2022-2023
Abstract In recent years, spherical nanoparticles has been studied extensively on biomedical applications including bioimaging and biosensing, diagnostics theranostics, but the effect of shape received little attention. present study, we designed three different shaped fluorescent mesoporous silica (MSNs), long rod (NLR), short (NSR), (NS) to systematically examine their behavior in vivo after oral administration. The results ex optical imaging study mice indicated that had a longer...
Exosomes are small extracellular vesicles released by cells for cell–cell communication. They play important roles in cancer development, metastasis, and drug resistance. Exosomal proteins have been demonstrated many studies as promising biomarkers screening, diagnosis, monitoring. Among detection techniques, surface plasmon resonance (SPR) is a highly sensitive, label-free, real-time optical method. Commercial prism-based wavelength/angular-modulated SPR sensors afford high sensitivity...
Purpose.: To evaluate the capability of a novel, coaligned focused ultrasound and phase-sensitive optical coherence elastography (US-OCE) system to assess age-related changes in biomechanical properties crystalline lens situ. Methods.: Low-amplitude elastic deformations young mature rabbit lenses were measured by an US-OCE consisting spectral-domain tomography (OCT) with used produce transient force on surface. Uniaxial compressional tests validate OCE data. Results.: The measurements showed...
In recent years, the direct coupling of solid phase microextraction (SPME) and mass spectrometry (MS) has shown its great potential to improve limits quantitation, accelerate analysis throughput, diminish matrix effects when compared injection MS. this study, we introduce open port probe (OPP) as a robust interface couple biocompatible SPME (Bio-SPME) fibers MS systems for electrospray ionization. The presented design consisted minimal alterations front-end instrument provided better...
We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI)-MS that creates transformative system enabling high-speed sampling label-free analysis. The ADE technology delivers nanoliter droplets in touchless manner with high speed, precision, accuracy. Subsequent sample dilution within OPI, concert capabilities modern ESI-MS, eliminates laborious...
High-throughput experimentation (HTE) has emerged as an important tool in drug discovery, providing a platform for preparing large compound libraries and enabling swift reaction screening over wide-ranging conditions. Recent advances automated high-density, material-sparing HTE have necessitated the development of rapid analytics with sensitivity resolution sufficient to identify products and/or assess performance timely data-rich manner. Combination ultrathroughput (UT) reader Acoustic...
We present an acoustic ejection mass spectrometry (AEMS) setup for contactless electrospray ionization (ESI-MS)-based sample injection at a sampling rate faster than current ESI and matrix-assisted laser desorption (MALDI) techniques. For the direct transfer of samples out 384-well plates into modified source, open port interface (OPI) was combined with droplet (ADE) system. AEMS has potential to eliminate bottlenecks known from classical MS approaches, such as speed, reproducibility,...
For nearly two decades mass spectrometry has been used as a label-free, direct-detection method for both functional and affinity-based screening of wide range therapeutically relevant target classes. Here, we present an overview several established emerging platforms summarize the unique strengths performance characteristics each they apply to high-throughput screening. Multiple examples from recent literature are highlighted in order illustrate power individual technique, with special...
The overwhelming magnitude of coal-fired power plants has caused an inevitable release metal-containing nanoparticles (MNPs) into the atmosphere, which may be inhaled respiratory system and cause oxidative stress. In this study, MNPs potential (OP) were analyzed in <1 μm fractions 56 coal fly ashes collected from Chinese CFPPs. particle number concentrations (PNCs) Fe- Ti-containing NPs, as dominant CFAs, range 1.5 × 109 to 9.4 1010 6.4 108 4.1 particles/mg, with average sizes 87 89 nm,...
Interests in covalent drugs have grown modern drug discovery as they could tackle challenging targets traditionally considered "undruggable". The identification of binders to target proteins typically involves directly measuring protein modifications using high-resolution mass spectrometry. With a continually expanding library compounds, conventional spectrometry platforms such LC-MS and SPE-MS become limiting factors for high-throughput screening. Here, we introduce prototype acoustic...
Understanding the mechanisms and energetics of ion solvation is critical in many scientific areas. Here, we present a methodlogy for studying using differential mobility spectrometry (DMS) coupled to mass spectrometry. While DMS cell, ions experience electric fields established by high frequency asymmetric waveform presence desired pressure water vapor. By observing how specific ion's behavior changes between high- low-field parts waveform, gain knowledge about aqueous microsolvation that...
Abstract Scoparone (6,7-dimethoxycoumarin) is the representative ingredient of Yinchenhao ( Artemisia capillaris Thunb.) which a famous Chinese medicinal herb and shows favorable efficacy for all kinds liver disease, specifically treatment Yanghuang syndrome (YHS). The precise molecular mechanism concerning action scoparone on YHS yet to be fully elucidated. aim present study was determine evaluate its metabolite levels. differential expression metabolites responsible pharmacological effects...
Acoustic ejection mass spectrometry is a recently developed concept in which low nanoliter-volume sample droplets are acoustically dispensed from microtiter plate wells into continuous fluid transfer open-port interface for subsequent ionization at atmospheric pressure. This manuscript focuses on the acoustic droplet dispensing component of prototype system, particular well-to-well sampling speed, volume calibration, precision, reproducibility, and various modes operation this device...
Abstract Periodical silver nanoparticle (NP) arrays were fabricated by magnetron sputtering method with anodic aluminum oxide templates to enhance the UV light emission from ZnO surface plasmon resonance effect. Theoretical simulations indicated that wavelength depended on diameter and space of Ag NP arrays. By introducing 40 nm 100 nm, photoluminescence intensity near band-edge was twofold enhanced. Time-resolved measurement energy band analysis enhancement attributed coupling between...
The open port interface (OPI) coupled to an atmospheric pressure ion source is used capture, dilute, focus, and transport nanoliter volume sample droplets for high-speed mass spectrometric analysis. For typical applications, the system has been optimized achieve 1 Hz transfer rates while simultaneously diluting >1000-fold minimize matrix-induced ionization suppression. Geometric, flow, dispensing alterations presented here demonstrate that OPI of at least 15 are possible. fluid dynamic...
Acoustic ejection mass spectrometry (AEMS) is an electrospray ionization-mass (ESI-MS) based analytical platform that provides high throughput and data quality. It has been applied in numerous drug discovery workflows, such as high-throughput screening (HTS), absorption, distribution, metabolism, excretion (ADME) profiling, pharmacokinetics (PK) analysis, compound quality control (QC), the readout of medical chemistry samples.This paper introduces working principle AEMS technology. The...