A5044376902- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- vaccines and immunoinformatics approaches
- Contact Dermatitis and Allergies
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Healthcare and Venom Research
- Urticaria and Related Conditions
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Occupational exposure and asthma
- Immune responses and vaccinations
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Breast Cancer Treatment Studies
- IL-33, ST2, and ILC Pathways
- Diabetes and associated disorders
- Cytomegalovirus and herpesvirus research
- Single-cell and spatial transcriptomics
- Breast Lesions and Carcinomas
Universitätsmedizin Göttingen
2021-2025
University of Göttingen
2021-2025
Abstract Background Homologous and heterologous SARS‐CoV‐2 vaccinations yield different spike protein‐directed humoral cellular immune responses. This study aimed to explore their currently unknown interdependencies. Methods COV‐ADAPT is a prospective, observational cohort of 417 healthcare workers who received vaccination with homologous ChAdOx1 nCoV‐19, BNT162b2 or nCoV‐19/BNT162b2. We assessed (anti‐spike‐RBD‐IgG, neutralizing antibodies, avidity) (spike‐induced T‐cell interferon‐γ...
There are conflicting data on a potential association between obesity and atopic dermatitis (AD). The purpose of this study was to investigate the relationship AD disease severity. Patients from TREATgermany registry cohort were divided into three groups according their body mass index (BMI). Due low numbers, underweight patients (BMI <18.5 kg/m2) excluded analysis. Physician- patient-reported severity scores as well additional phenotypic characteristics evaluated for with BMI. Generalized...
Multiparameter immunoblot testing is increasingly used as an alternative to multiple individual IgE analyses for type 1 allergies. This study investigated the performance of inexpensive method, RIDA qLine allergy test system (R-Biopharm AG), vs. current gold standard. Three study-specific panels with 57 allergens (food and aeroallergens) were analyzed in serum samples from 200 patients signs symptoms IgE-mediated allergies, using both Allergy reference ImmunoCAP Specific (Thermo Fisher...
Graphical abstractAbstractBackgroundInsight into the pathophysiology of inflammatory skin diseases, especially at proteomic level, is severely hampered by lack adequate in situ data.ObjectiveWe characterized lesional and nonlesional diseases using microdialysis.MethodsSkin microdialysis samples from patients with atopic dermatitis (AD, n = 6), psoriasis vulgaris (PSO, 7), or prurigo nodularis (PN, as well healthy controls (n were subjected to multiplex cytokine analysis. Single-cell RNA...
Anti-SARS-CoV-2-specific serological responses are a topic of ongoing evaluation studies. In the study presented here, anti-SARS-CoV-2 surrogate neutralization assays by TECOmedical and DiaPROPH -Med were assessed in head-to-head comparison with serum samples individuals after vaccination as well previous infection SARS-CoV-2. case discordant results, cell culture-based assay was applied reference standard. The showed sensitivity specificity 100% 61.3%, respectively, DiaPROPH-Med 95.0%...
Allergies against Hymenoptera venoms are a major cause of severe anaphylaxis. Risk assessment for subjects with suspected allergy is difficult because there currently no biomarkers that predict the likelihood high-grade anaphylaxis other than several associated comorbidities.We investigated relationship between severity and results intracutaneous skin tests (ICTs) together serum levels tryptase, total IgE, venom-specific IgG, IgG4.We performed retrospective evaluation 194 patients who...
Summary Background Allergic medical care in Germany is organized on an interdisciplinary basis. An overview of the current situation necessary to manage and improve cooperation. Methods Between January February 2022, questionnaires were sent online by mail chief physicians inpatient clinical departments which most allergological diseases are assigned (dermatology, otorhinolaryngology [ENT], pulmonology, pediatrics, environmental/occupational medicine, gastroenterology; n = 899). Results The...
Introduction: In adults, allergic reactions to insect stings are among the most frequent causes of anaphylaxis, a potentially life-threatening condition. Recurrent anaphylaxis following vespid may be prevented by allergen immunotherapy (AIT). The aim this study was evaluate benefit measuring venom-induced wheal area in intracutaneous skin tests (ICT), comparison various serological and clinical parameters, for diagnosis severe venom allergy during follow-up AIT. Methods: We conducted...
Background : Homologous and heterologous SARS-CoV-2 vaccinations yield different spike protein-directed humoral cellular immune responses. This study aimed to explore their currently unknown interdependencies. Methods COV-ADAPT is a prospective, observational cohort of 417 healthcare workers who received vaccination with homologous ChAdOx1 nCoV-19, BNT162b2 or nCoV-19/BNT162b2. We assessed (anti-spike-RBD-IgG, neutralizing antibodies, avidity) (spike-induced T cell interferon‑γ release)...
Despite recent advances in prophylactic vaccination, SARS-CoV-2 infections continue to cause significant morbidity. A better understanding of immune response differences between vaccinated individuals with and without later breakthrough infection is urgently needed. CoV-ADAPT a prospective long-term study comparing humoral (anti-spike-RBD-IgG, neutralization capacity, avidity) cellular (spike-induced T-cell interferon-γ [IFN-γ] release) responses against at four different time points (three...
Abstract Background Pruritus is a symptom profoundly impairing patients' quality of life (QoL). It common in chronic heart failure (CHF) patients yet unknown nature. The aim this study was to evaluate the risk factors pruritus CHF patients. Methods For monocentric, prospective cohort study, were recruited and symptoms, comorbidities drug intake assessed using structured report. Additionally, questionnaire evaluated symptoms. Detailed medical histories including laboratory test results...
Abstract Objectives Occupational hand eczema is a common inflammatory skin condition among healthcare professionals. Orthodontists are frequently exposed to variety of irritating and allergenic substances, therefore they belong predisposed group develop eczema. However, current data on the prevalence predisposing factors orthodontists provide adequate prophylaxis lacking. Methods An anonymous online survey was conducted in Germany between January February 2023 distributed 2402 orthodontists....
Anti-rubella IgG serum levels predict risk for SARS-CoV-2 breakthrough infectionsTo the Editor, infections among vaccinated individuals are common. 1The identification of people at such remains challenging. 2Immunological factors have long been recognized to play a central role in prevention viral infections; however, we were unable extensively studied CoV-ADAPT cohort using machine learning approach based on SARS-CoV-2-specific, longitudinal, immunological data from different time points...
Despite recent advances in prophylactic vaccination, SARS-CoV-2 infections continue to cause significant morbidity. A better understanding of immune response differences between vaccinated individuals with and without later breakthrough infection is urgently needed. CoV-ADAPT a prospective long-term study comparing humoral (anti-spike-RBD-IgG, neutralization capacity, avidity) cellular (spike-induced T-cell interferon-γ release) responses against at four different time points (three before...
Allergic diseases represent a broad spectrum of high-prevalence, chronic conditions that remain underdiagnosed and undertreated. The aims this interdisciplinary, questionnaire-based, non-interventional study were to identify analyze potential barriers clinical allergological care in Germany.All hospitals listed the German hospital register involved treatment patients (n = 899) invited participate. yielded response rate 52.1% 468).Overall, 88.5% clinics agreed Germany needs improvement,...
Die Allergologie ist in Deutschland interdisziplinär organisiert. Zur Steuerung und Verbesserung fachbereichsübergreifender Kooperationen ein Überblick über die aktuelle Versorgungssituation notwendig.Zwischen Januar Februar 2022 wurden online postalisch Fragebögen an Leitungen stationärer klinischer Fachbereiche versendet, denen meisten allergologischen Krankheitsbilder zugeordnet werden (Dermatologie, HNO, Pneumologie, Pädiatrie, Umwelt/Arbeitsmedizin, Gastroenterologie; n = 899).Die...
Background: Humoral and cellular immune responses to SARS-CoV-2 vaccines wane with time. In the COV‑ADAPT cohort, we recently studied both immunological components their interdependencies following different vaccine combinations before (T1) up three months after second immunization (T2). This follow-up investigated stability of long-term aimed identify predictive markers. Methods: We assessed humoral (anti-spike-RBD-IgG, neutralization capacity, avidity) (spike-induced T-cell interferon‑γ...
Abstract Background Homologous and heterologous SARS-CoV-2-vaccinations yield different spike protein-directed humoral cellular immune responses. However, their interdependencies remain elusive. Methods COV-ADAPT is a prospective, observational cohort study of 417 healthcare workers who received homologous vaccination with Astra (ChAdOx1-S; AstraZeneca) or BNT (BNT162b2; Biontech/Pfizer) Astra/BNT. We assessed the (anti-spike-RBD-IgG, neutralizing antibodies, antibody avidity) (spike-induced...
Background : Homologous and heterologous SARS-CoV-2 vaccinations yield different spike protein-directed humoral cellular immune responses. This study aimed to explore their currently unknown interdependencies. Methods COV-ADAPT is a prospective, observational cohort of 417 healthcare workers who received vaccination with homologous ChAdOx1 nCoV-19, BNT162b2 or nCoV-19/BNT162b2. We assessed (anti-spike-RBD-IgG, neutralizing antibodies, avidity) (spike-induced T cell interferon‑γ release)...