A5047116832- Magnesium Alloys: Properties and Applications
- Orthopaedic implants and arthroplasty
- Hydrogen Storage and Materials
- Bone Tissue Engineering Materials
- Corrosion Behavior and Inhibition
- Titanium Alloys Microstructure and Properties
- Aluminum Alloys Composites Properties
- Tissue Engineering and Regenerative Medicine
- Magnesium in Health and Disease
- Orthopedic Infections and Treatments
- Additive Manufacturing Materials and Processes
- 3D Printing in Biomedical Research
- Dental Implant Techniques and Outcomes
- International Environmental Law and Policies
- Advanced Welding Techniques Analysis
- Total Knee Arthroplasty Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Mechanical Failure Analysis and Simulation
TU Dortmund University
2018-2023
Magnesium (Mg)-based biomaterials are promising candidates for bone and tissue regeneration. Alloying surface modifications provide effective strategies optimizing tailoring their degradation kinetics. Nevertheless, biocompatibility analyses of Mg-based materials challenging due to its special mechanism with continuous hydrogen release. In this context, the release related (micro-) milieu conditions pretend strictly follow in vitro standards based on ISO 10993-5/-12. Thus, adaptions testing...
Introduction: Bioresorbable collagenous barrier membranes are used to prevent premature soft tissue ingrowth and allow bone regeneration. For volume stable indications, only non-absorbable synthetic materials available. This study investigates a new bioresorbable hydrofluoric acid (HF)-treated magnesium (Mg) mesh in native collagen membrane for situations. Materials Methods: HF-treated untreated Mg were compared direct indirect cytocompatibility assays. In vivo, 18 New Zealand White Rabbits...
Laser powder bed fusion (L-PBF) of metals enables the manufacturing highly complex geometries which opens new application fields in medical sector, especially with regard to personalized implants. In comparison conventional techniques, L-PBF causes different microstructures, and thus, challenges arise. The main objective this work is investigate influence parameters process on microstructure, process-induced porosity, as well corrosion fatigue properties magnesium alloy WE43 a reference...
The degradation rate of magnesium (Mg) alloys is a key parameter to develop Mg-based biomaterials and ensure in vivo-mechanical stability as well minimize hydrogen gas production, which otherwise can lead adverse effects clinical applications. However, vitro vivo results the same material often differ largely. In present study, dynamic test bench with several single bioreactor cells was constructed measure volume evolves during indicate vivo. Degradation medium comparable human blood plasma...
In this study, microvascular network structures for tissue engineering were generated on newly developed macroporous polydioxanone (PDO) scaffolds. PDO represents a polymer biodegradable within months and offers optimal material properties such as elasticity nontoxic degradation products. scaffolds prepared by porogen leaching cryo-dried to achieve pore sizes of 326 ± 149.67 μm remained stable with equivalent values Young's modulus after 4 weeks. Scaffolds coated fibrin cell adherence. To...
Magnesium (Mg)-based biomaterials hold considerable promise for applications in regenerative medicine. However, the degradation of Mg needs to be reduced control toxicity caused by its rapid natural corrosion. In process developing new alloys with various surface modifications, an efficient assessment relevant properties is essential. present study, a WE43 alloy plasma electrolytic oxidation (PEO)-generated was investigated. Surface microstructure, hydrogen gas evolution immersion tests and...
The present publication reports the purification effort of two natural bone blocks, that is, an allogeneic block (maxgraft®, botiss biomaterials GmbH, Zossen, Germany) and a xenogeneic (SMARTBONE®, IBI S.A., Mezzovico-Vira, Switzerland) in addition to previously published results based on histology. Furthermore, specialized scanning electron microscopy (SEM) vitro analyses (XTT, BrdU, LDH) for testing cytocompatibility ISO 10993-5/-12 have been conducted. microscopic showed both blocks...
Abstract Implants of different material classes have been used for the reconstruction damaged hard and soft tissue decades. The aim is to increase subsequently maintain patient's quality life through implantation. In service, most implants are subjected cyclic loading, which must be taken particularly into consideration, since fatigue strength far below yield tensile strength. Inaccurate estimation structural due consideration or leads a miscalculation implant's lifetime, therefore, its...
In regenerative medicine, degradable, magnesium-based biomaterials represent a promising material class. The low corrosion resistance typical for magnesium is advantageous this application since the entire implant degrades in presence of aqueous body fluids after fulfilling intended function, making second operation removal obsolete. To ensure sufficient stability within functional phase, degradation behavior must be known months. order to reduce time and costs these long-time...
In the field of surgery, bioresorbable magnesium is considered a promising candidate. Its low corrosion resistance, which disadvantageous for technical application, advantageous surgery since implant fully degrades in presence water-based body fluids, and after defined time regenerating bone takes over its function again. Therefore, knowledge behavior several months essential. For this reason, an vitro short-time testing method developed to accelerate progress by galvanostatic anodic...
For surgery, biodegradable magnesium alloys are considered promising candidates. The low corrosion resistance is advantageous since the implant degraded in presence of aqueous body fluids, supporting human bone for a defined time and be fully after this functional phase, making second surgery removal unnecessary. To design phase prevent early failure, precise knowledge degradation behavior over months correlating mechanical stability essential. In vitro tests required duration associated...