A5074015110- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects of Natural Compounds
- Quinazolinone synthesis and applications
- Genomics, phytochemicals, and oxidative stress
- Galectins and Cancer Biology
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- interferon and immune responses
- Essential Oils and Antimicrobial Activity
- Phytochemistry and biological activities of Ficus species
- Viral gastroenteritis research and epidemiology
- Berberine and alkaloids research
- Garlic and Onion Studies
- Fire effects on ecosystems
- Veterinary medicine and infectious diseases
- Flavonoids in Medical Research
- Viral Infections and Outbreaks Research
- Influenza Virus Research Studies
- Cytokine Signaling Pathways and Interactions
- Ginger and Zingiberaceae research
- IL-33, ST2, and ILC Pathways
- RNA Interference and Gene Delivery
- Sphingolipid Metabolism and Signaling
Hainan University
2024-2025
Sanya University
2025
Chengdu University of Traditional Chinese Medicine
2020-2021
Chinese PLA General Hospital
2020-2021
Background: Rutaecarpine (RUT), a major quinazolino carboline alkaloid compound from the dry unripe fruit Tetradium ruticarpum (A. Juss.) T. G. Hartley, has various pharmacological effects. The aim of this present study was to investigate potential gastroprotective effect rutaecarpine on ethanol-induced acute gastric mucosal injury in mice and associated molecular mechanisms, such as activating Nrf2 Bcl-2 via PI3K/AKT signaling pathway inhibiting NF-κB. Methods: Gastric ulcer index...
This study was aimed to explore the mechanism of rutaecarpine (RUT) on ethanol-induced gastric ulcer (GU) in mice by integrated approaches. At first, efficacy determined through macroscopic and microscopic state stomach tissue expression levels GU-related factors. Then, serum metabolomics method based UPLC-Q-TOF/MS used specific metabolites metabolic pathways. Finally, upstream key protein targets these were analyzed network pharmacology verified PCR potential mechanism. RUT alleviated...
Aim. The aim of this study was to explore the antipyretic effect and potential mechanism Huanglian Jiedu Decoction (HLJDD) on LPS-induced fever in rats. Materials Methods. rat model established by LPS. Anal temperature rats measured every 1 hour after modeling. TNF-α, IL-6, PGE2, cAMP serum or hypothalamus tissue were detected ELISA kit. In order active ingredients HLJDD, we predicted underlying using network pharmacology then verified its Western Blotting. Results. results showed that HLJDD...
Seasonal outbreaks and occasional pandemics triggered by influenza viruses annually impose considerable burdens on public health finances. The continual evolution of viral strains with drug resistance emphasizes the urgency discovering novel agents for viruses. This study investigated a set innovative substances derived from Morinda officinalis antiviral potential against virus strains. top candidate, anthraquinone-2-carboxylic acid (A2CA), presented activity diverse strains, including those...
The main objective of this study was to investigate the ameliorative effects Palmatine (Pal) on Helicobacter pylori (H. pylori) induced chronic atrophic gastritis (CAG).Body function, serum biochemical indicators and histopathology were used evaluate pharmacodynamics Pal CAG rats. target genes expression levels verified assessed by RT-PCR immunohistochemistry (IHC). Moreover, UPLC-Q-TOF/MS analysis based urine performed identify potential metabolites in pathological process H. pylori....
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne that causes the severe syndrome, which manifests as and haemorrhage, accompanied by neurological complications. To date, no specific antiviral drugs have been approved for this indication. Herein, we investigated whether vitamin D derivatives inhibit SFTSV both in vitro vivo. An study demonstrated significantly suppressed viral RNA replication, plaque formation, protein expression dose-dependent manner. Subsequently,...
Severe fever with thrombocytopenia syndrome virus (SFTSV), also known as the Dabie Banda virus, is an emerging tick-borne Bunyavirus that causes severe (SFTS). Currently, symptomatic treatment and antiviral therapy ribavirin favipiravir are used in clinical management. However, their therapeutical efficacy hardly satisfactory patients high viral load. In this study, we explored effects of selective estrogen receptor modulators (SERMs) on SFTSV infection mechanisms a representative SERM,...
Zuojin Pill (ZJP) is widely used for the treatment of gastrointestinal diseases, while its specific mechanism has not been systematically investigated. The aim this study was to explore therapeutic effects and potential ZJP in chronic atrophic gastritis (CAG) through UPLC-Q-TOF/MS-based metabolomics combined with network pharmacology. omeprazole significantly reduce contents IL-1β, IL-6, IL-10, iNOS improve pathological characteristics. Metabolomic results indicated that were mainly related...
Abstract Background: Zuojin Pill (ZJP), a famous Chinese medicinal formula, widely accepted for treatment of chronic atrophic gastritis (CAG) in China. This study aimed to explore the therapeutic effects and mechanisms ZJP Helicobacter pylori (H. pylori) - induced vivo vitro. Methods: CAG rat model was by H. pylori. (0.63, 1.26, 2.52 g/kg, respectively) administered orally four weeks. Therapeutic were identified H&E staining serum indices. In addition, cell viability, morphology...
Abstract Background Zuojin Pill (ZJP) is widely used for the treatment of gastrointestinal diseases, while its specific mechanism has not been systematically investigated. The aim this study was to explore intervention ZJP in chronic atrophic gastritis (CAG) through metabolomics combined with network pharmacology. Materials and methods Potential metabolites possible pathways CAG were explored using a UPLC-Q-TOF/MS-based technique. key targeting by combining analysis Results significantly...
Abstract Background: Zuojin Pill (ZJP), a famous Chinese medicinal formula, is widely accepted for treatment of chronic atrophic gastritis (CAG) in China. This study aimed to explore the therapeutic effects and mechanisms ZJP Helicobacter pylori ( H. ) - induced vivo vitro . Methods: CAG rat model was by (0.63, 1.26, 2.52 g/kg, respectively) administered orally four weeks. Therapeutic were identified H&E staining serum indices. In addition, cell viability, morphology proliferation...
Abstract Objective Zuojin Pill (ZJP) containing two Chinese herbal drugs: Coptidis Rhizoma and Euodiae Fructus is a classical formula widely accepted as treatment of chronic atrophic gastritis (CAG) in China. This study aimed to explore the therapeutic effect mechanism ZJP which attenuated H. pylori -induced CAG vivo vitro.Methods: (Helicobacter pylori) was used induce rat model. 0.63, 1.26, 2.52 g/kg (was administered orally for four weeks. Therapeutic identified by H & E staining serum...
Abstract As a prevalent digestive disease, Gastric ulcer (GU) has high incidence and is seriously harmful to human health. It an urgent need finding natural drug with gastroprotective effect. Rutaecarpine (RUT) alkaloid isolated from Evodia rutaecarpa Bentham (Rutaceae). This plant traditional Chinese medicine that been treating gastrointestinal diseases for long time. The present study aimed investigate the effects of RUT on ethanol-induced acute GU in mice. After intragastrical...
Abstract Background: Zuojin Pill (ZJP), a classic prescription, has the potential to prevent ulcerative colitis (UC). However, active component and mechanism of ZJP is still arcane. Objective: This study aims use network pharmacology approach find bioactive compounds action mechanisms in treatment UC. Methods: Firstly, components putative targets were collected based on herbal medicine target database, containing interaction between therapeutic UC was established. Then topological parameters...