A5100336559- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Lipid metabolism and biosynthesis
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- HIV Research and Treatment
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Healthcare professionals’ stress and burnout
- Misinformation and Its Impacts
- Selenium in Biological Systems
- Cancer Mechanisms and Therapy
- Frailty in Older Adults
- TGF-β signaling in diseases
- HIV/AIDS Research and Interventions
Sichuan University
2015-2025
State Key Laboratory of Biotherapy
2021-2025
Changchun University of Science and Technology
2025
Harbin Medical University
2025
First Affiliated Hospital of Harbin Medical University
2025
Yangtze University
2024
Anhui Medical University
2024
Guangdong University of Foreign Studies
2023
West China Second University Hospital of Sichuan University
2023
West China Hospital of Sichuan University
2022
Metastasis is a major cause of colorectal cancer (CRC) mortality, but its molecular mechanisms are still not fully understood. Here, we show that upregulated DDX39B correlates with liver metastases and aggressive phenotypes in CRC. an independent prognostic factor associated poor clinical outcome CRC patients. We demonstrate Sp1 potently activates transcription by directly binding to the GC box promoter cells. overexpression augments proliferation, migration, invasion cells, while opposite...
Abstract DEAD box helicase 17 (DDX17) has been reported to be involved in the initiation and development of several cancers. However, functional role mechanisms DDX17 colorectal cancer (CRC) malignant progression metastasis remain unclear. Here, we that expression was increased CRC tissues compared with noncancerous mucosa further upregulated liver patient-paired primary tumors. High levels were significantly correlated aggressive phenotypes worse clinical outcomes patients. Ectopic promoted...
Colorectal cancer (CRC) is one of the most common cancers worldwide and its metastasis accounts for majority deaths. However, molecular mechanisms underlying CRC progression are not well characterized. In this study, we identified miR‐409‐3p as a tumor suppressor CRC. MiR‐409‐3p expression was significantly downregulated in tissue compared to adjacent non‐tumor tissue, reduced correlated with metastasis. vitro vivo studies revealed that negatively regulated metastatic capacities, including...
We conducted a national survey among medical students in China to estimate the prevalence of depressive symptoms and explore associated risk factors based on an established questionnaire composed demographic information, life events past four weeks before survey, validated Chinese version 21-item Beck's Depression Inventory (BDI). The mean age enrolled 9010 was 20.7 (standard deviation: 1.6) years. BDI scores indicated that 19.9% had cut-off score 14. Socioeconomic student characteristics...
Abstract Breast cancer is the most common in world. Relapse and metastasis are important factors endangering life of breast patients, but mechanism still unclear. The stabilization p53 essential for preventing carcinogenesis, ubiquitination one main ways to regulate stability p53. Tripartite motif-containing 31 (TRIM31) a new member TRIM family functions as an E3 ubiquitin ligase. It acts promoter or suppressor malignant processes multiple cancers. However, function TRIM31 progression...
Abstract Breast cancer is the most frequently diagnosed malignancy and leading cause of cancer‐related deaths in women worldwide. Cancer‐associated fibroblasts (CAFs) are one fundamental cellular components tumor microenvironment play a critical role initiation, progression, therapy resistance breast cancer. However, detailed molecular mechanisms CAFs activation from normal (NFs) still not well understood. In present study, we reported that ZNF32 expression cells was negatively correlated...
Toll-like receptors (TLRs) are important components of the innate and adaptive immune systems, abnormal TLR expression has been linked to a variety cancers. However, there was lack clarity on association stimulation with carcinogenesis cancer. The study's goal analyse clinical importance TLRs at mRNA level in pan-cancer datasets, as well link between carcinogenesis, progression, prognosis.The profile derived from UCSC data analysed multiple dimensions, including analysis, immunological...
Abstract Background Despite significant strides in lung cancer immunotherapy, the response rates for Kirsten rat sarcoma viral oncogene homolog ( KRAS )‐driven adenocarcinoma (LUAD) patients remain limited. Fibrinogen‐like protein 1 (FGL1) is a newly identified immune checkpoint target, and study of related resistance mechanisms crucial improving treatment outcomes LUAD patients. This aimed to elucidate potential mechanism by which FGL1 regulates tumor microenvironment ‐mutated cancer....
The results of our previous study showed that impaired cellular energy metabolism contributes to duck enteritis virus-induced autophagy via the 5`-adenosine monophosphate-activated protein kinase (AMPK)/tuberous sclerosis complex 2/mammalian target rapamycin pathway in embryo fibroblast (DEF) cells. However, it remains unknown whether any other underlying mechanisms AMPK activation are involved induction. activity CaMKKβ and DEF cells infected with DEV were evaluated.The Effect inhibitory on...
The present study explored the alignment effect of sight translation continuation task (STCT) and its possible influence on (ST) fluency. Thirty-four third-year English Education majors at a Chinese university were divided into two groups in study. experimental group who conducted STCT read source text speech Chinese, while control only text. Afterwards, both translated continued Chinese. results indicated that (a) aligned with pre-reading lexical level (b) improved ST fluency to some extent...
To study the correlation between N 6-methyladenosine (m 6A)-modification-associated long non-coding RNAs (lncRNAs) and poor prognosis immunotherapy in cervical cancer based on data mining of The Cancer Genome Atlas (TCGA) dataset, so as to assess effectively patients feasibility immunotherapy.We identified m 6A-modification-associated lncRNAs correlated by conducting bioinformatics analysis samples from TCGA datasets constructed a prognostic risk model accordingly.A total 343 were 304...