A5061693850- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- NF-κB Signaling Pathways
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Cholesterol and Lipid Metabolism
- Epigenetics and DNA Methylation
- Bone and Dental Protein Studies
- Ocular Diseases and Behçet’s Syndrome
- International Relations and Foreign Policy
- Mobile Agent-Based Network Management
- Lipid metabolism and biosynthesis
- TGF-β signaling in diseases
- Retinal Imaging and Analysis
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Railway Systems and Energy Efficiency
- Retinal and Optic Conditions
- Mosquito-borne diseases and control
- Peroxisome Proliferator-Activated Receptors
- European Politics and Security
State Key Laboratory of Biotherapy
2021-2025
Sichuan University
2020-2025
Tohoku University
1998-2024
Shanghai Tenth People's Hospital
2024
Hangzhou Medical College
2022-2024
Zhejiang Provincial People's Hospital
2022-2024
Tongji University
2024
Yan'an University
2024
Air Force Medical University
2024
Xinxiang Medical University
2024
Metastasis is a major cause of colorectal cancer (CRC) mortality, but its molecular mechanisms are still not fully understood. Here, we show that upregulated DDX39B correlates with liver metastases and aggressive phenotypes in CRC. an independent prognostic factor associated poor clinical outcome CRC patients. We demonstrate Sp1 potently activates transcription by directly binding to the GC box promoter cells. overexpression augments proliferation, migration, invasion cells, while opposite...
Abstract DEAD box helicase 17 (DDX17) has been reported to be involved in the initiation and development of several cancers. However, functional role mechanisms DDX17 colorectal cancer (CRC) malignant progression metastasis remain unclear. Here, we that expression was increased CRC tissues compared with noncancerous mucosa further upregulated liver patient-paired primary tumors. High levels were significantly correlated aggressive phenotypes worse clinical outcomes patients. Ectopic promoted...
Abstract Breast cancer is the most common in world. Relapse and metastasis are important factors endangering life of breast patients, but mechanism still unclear. The stabilization p53 essential for preventing carcinogenesis, ubiquitination one main ways to regulate stability p53. Tripartite motif-containing 31 (TRIM31) a new member TRIM family functions as an E3 ubiquitin ligase. It acts promoter or suppressor malignant processes multiple cancers. However, function TRIM31 progression...
Purpose: We aimed to investigate the status of serum 25-hydroxyvitamin D [25(OH)D] among Chinese postmenopausal women in a multicenter cross-sectional study. Methods: Non-institutionalized aged ≥55 years were recruited from urban and rural areas 7 geographically different regions China. Subject enrollment was executed during summer winter. Vitamin insufficiency deficiency defined as 25(OH)D16.78ng/mL. Conclusions: The prevalence vitamin inadequacy remarkable independent fracture risk...
Abstract Breast cancer is the most frequently diagnosed malignancy and leading cause of cancer‐related deaths in women worldwide. Cancer‐associated fibroblasts (CAFs) are one fundamental cellular components tumor microenvironment play a critical role initiation, progression, therapy resistance breast cancer. However, detailed molecular mechanisms CAFs activation from normal (NFs) still not well understood. In present study, we reported that ZNF32 expression cells was negatively correlated...
Diabet. Med. 28, 1088–1095 (2011) Abstract Aim To determine if a regimen with prandial + basal insulin compared attenuates post‐meal inflammatory and glycative biomarkers in patients Type 2 diabetes. Methods This test‐meal sub‐study the USA is from previously reported clinical trial comparing effect on glycaemic control of 24 weeks thrice‐daily pre‐meal lispro mix 50 (50% lispro, 50% protamine suspension) or bedtime glargine, both plus metformin. In sub‐study, glucose, insulin,...
The periodontal ligament is a soft connective tissue embedded between the alveolar bone and cementum, surface hard of teeth. Periodontal fibroblasts (PDLF) actively express osteo/cementogenic genes, which contribute to homeostasis. However, key factors maintaining abilities PDLF remain unclear. We herein demonstrated that PPARγ was expressed by in vivo its distribution pattern correlated with alkaline phosphate enzyme activity. knockdown markedly reduced vitro, whereas agonists exerted...
Diabetic retinopathy (DR) includes a series of typical lesions affected by retinal microvascular damage caused diabetes mellitus (DM), which not only seriously damages the vision, affecting life's quality patients, but also brings considerable burden to family and society. Astragalus Membranaceus (AM) is commonly used medicine in clinical therapy eye disorders traditional Chinese (TCM). In recent years, it for treating DR, specific mechanism unclear. Therefore, this study explores potential...
Enforced enrichment of the active promoter marks trimethylation histone H3 lysine 4 (H3K4me3) and acetylation 27 (H3K27ac) by inhibiting demethylases deacetylases is positively associated with hard tissue formation through induction osteo/odontogenic differentiation. However, key endogenous epigenetic modulator odontoblasts to regulate expression genes coding dentin extracellular matrix (ECM) proteins has not been identified. We focused on nuclear factor (NF)–κB inhibitor ζ (IκBζ), which was...
Due to their multi-differentiation potential, periodontal ligament fibroblasts (PDLF) play pivotal roles in tissue regeneration vivo. Several vitro studies have suggested that PDLFs can transmit mechanical stress into favorable basic cellular functions. However, the application of force for therapy is not expected exhibit an effective prognosis since forces, such as traumatic occlusion, also exacerbate degeneration and loss. Herein, we established a standardized murine model evaluated...
Accumulating evidence indicates that RNA methylation at N
Hypoxia-mediated tumor progression is a major problem in colorectal cancer (CRC). MicroRNA (miR)-200b-3p can attenuate tumorigenesis CRC, while exosomal miRNAs derived from cancer-associated fibroblasts (CAFs) promote progression. Nevertheless, the function of miR-200b-3p CAFs CRC remains unclear. In this study, and normal (NFs) were isolated adjacent tissues. Next, exosomes supernatants cultured under normoxia hypoxia. Cell viability was tested using cell counting kit-8 assay, flow...
Dental pulp stem cells (DPSC) usually remain quiescent in the dental tissue; however, once tissue is injured, DPSCs potently proliferate and migrate into injury microenvironment contribute to immuno-modulation repair. However, key molecules that physiologically support potent proliferation migration of have not been revealed. In this study, we searched publicly available transcriptome raw data sets, which contain comparable (i.e., equivalently cultured) DPSC mesenchymal cell data. Three sets...