A5071243292- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune responses and vaccinations
- Vagus Nerve Stimulation Research
- COVID-19 and Mental Health
University Hospital of Zurich
2021-2024
University of Zurich
2021-2024
Abstract Following acute infection with severe respiratory syndrome coronavirus 2 (SARS-CoV-2) a significant proportion of individuals develop prolonged symptoms, serious condition termed post-acute disease 2019 (COVID-19) (PACS) or long COVID. Predictors PACS are needed. In prospective multicentric cohort study 215 individuals, we COVID-19 patients during primary and up to one year later, compared healthy subjects. We discover an immunoglobulin (Ig) signature, based on total IgM IgG3...
Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses blood serum from COVID-19 patients followed up to 12 months after confirmed severe acute respiratory syndrome coronavirus 2 infection. Analysis >6500 proteins in 268 longitudinal samples revealed dysregulated activation the complement system, an innate immune protection and homeostasis mechanism, individuals experiencing Covid. Thus, active was characterized by terminal system...
Abstract Immunological memory is a hallmark of adaptive immunity and facilitates an accelerated enhanced immune response upon re-infection with the same pathogen 1,2 . Since outbreak ongoing COVID-19 pandemic, key question has focused on which SARS-CoV-2-specific T cells stimulated during acute infection give rise to long-lived 3 Here, using spectral flow cytometry combined cellular indexing transcriptomes cell receptor sequencing, we longitudinally characterized individual CD8 + patients...
Abstract Infection with severe acute respiratory syndrome coronavirus 2 associates diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors associated adverse disease 2019 (COVID-19) outcomes. Here we discovered that against specific chemokines were omnipresent post-COVID-19, favorable outcome negatively correlated the development of long COVID at 1 yr post-infection. Chemokine also present in HIV-1...
Several autoimmune features occur during coronavirus disease 2019 (COVID-19), with possible implications for course, immunity, and pathology. In this study, we longitudinally screened clinically relevant systemic autoantibodies to assess their prevalence, temporal trajectory, association comorbidities, severity of COVID-19.We performed highly sensitive indirect immunofluorescence assays detect antinuclear antibodies (ANA) antineutrophil cytoplasmic (ANCA), along serum proteomics virome-wide...
Abstract The B cell response to different pathogens uses tailored effector mechanisms and results in functionally specialized memory (B m ) subsets, including CD21 + resting, – CD27 activated cells. interrelatedness between these subsets remains unknown. Here we showed that single severe acute respiratory syndrome coronavirus 2-specific clones plasticity upon antigen rechallenge previously exposed individuals. cells were the predominant during infection early after immunization. At months 6...
T-cell lymphopenia and functional impairment is a hallmark of severe acute coronavirus disease 2019 (COVID-19). How numbers function evolve at later timepoints after clinical recovery remains poorly investigated.
Abstract Background Several autoimmune features occur during coronavirus disease 2019 (COVID-19), with possible implications for course, immunity, and pathology. In this study, we longitudinally screened clinically relevant systemic autoantibodies to assess their prevalence, temporal trajectory, association comorbidities, severity of COVID-19. Methods We performed highly sensitive indirect immunofluorescence assays detect anti-nuclear antibodies (ANA) anti-neutrophil cytoplasmic (ANCA),...
Abstract Infection by SARS-CoV-2 leads to diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors associated with adverse COVID-19 outcomes. Instead, we discovered that against specific chemokines omnipresent after COVID-19, favorable disease, predictive of lack long COVID symptoms at one year post infection. Anti-chemokine present also in HIV-1 infection autoimmune disorders, but they target different...
Following acute infection with severe respiratory syndrome coronavirus 2 (SARS-CoV-2) a significant proportion of individuals develop prolonged symptoms, serious condition termed post-acute disease 2019 (COVID-19) (PACS) or long COVID.Predictors PACS are needed.In prospective multicentric cohort study 215 individuals, we COVID-19 patients during primary and up to one year later, compared healthy subjects.We discover an immunoglobulin (Ig) signature, based on total IgM IgG3 levels,...
Abstract B cell responses to different pathogens recruit tailored effector mechanisms, resulting in functionally specialized subsets. For human memory cells (MBCs), these include CD21 + resting, − CD27 activated, and atypical cells. Whether subsets follow deterministic or interconnected fates is unknown. We demonstrate COVID-19 patients that single clones of SARS-CoV-2-specific MBCs followed multiple with distinctive phenotypic functional characteristics. 6–12 months after infection, most...
Abstract Immunological memory is a hallmark of adaptive immunity and facilitates an accelerated enhanced immune response upon re-infection with the same pathogen 1,2 . Since outbreak ongoing coronavirus disease 19 (COVID-19) pandemic, key question has focused on whether severe acute respiratory syndrome 2 (SARS-CoV-2)-specific T cells stimulated during infection give rise to long-lived 3 Using spectral flow cytometry combined cellular indexing transcriptomes cell receptor (TCR) sequencing we...