A5093751486- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
Ludwig-Maximilians-Universität München
2025
University of Zurich
2024-2025
University Hospital of Zurich
2024
Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses blood serum from COVID-19 patients followed up to 12 months after confirmed severe acute respiratory syndrome coronavirus 2 infection. Analysis >6500 proteins in 268 longitudinal samples revealed dysregulated activation the complement system, an innate immune protection and homeostasis mechanism, individuals experiencing Covid. Thus, active was characterized by terminal system...
In pDCs, BTK-inhibition (BTKi) blocks the IFN-α production via TLR-9, but not TLR-7. Upon TLR-7 stimulation, BTKi enhances of by blocking inhibitory BDCA-2 pathway. This might explain partially failure in SLE and is interest for trials multiple sclerosis.