A5073858183- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Treatments and Studies
- Biliary and Gastrointestinal Fistulas
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Diseases and Immunity
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Screening and Detection
- Multiple and Secondary Primary Cancers
- Cancer Genomics and Diagnostics
- Pelvic and Acetabular Injuries
- Genetic and Kidney Cyst Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neurofibromatosis and Schwannoma Cases
- Abdominal Trauma and Injuries
- Intestinal and Peritoneal Adhesions
- Gastrointestinal disorders and treatments
- Aortic aneurysm repair treatments
- Immune cells in cancer
- Diabetes Treatment and Management
Centre Hospitalier Universitaire de Nantes
2011-2021
Nantes Université
2016-2020
Hôpital Paul-Brousse
2003-2004
Hotel Dieu Hospital
2002
Hôpital Laennec
2001
UCLouvain
2001
To answer whether synchronous colorectal cancer liver metastases (SLM) should be resected simultaneously with primary or delayed.Numerous studies have compared both strategies. All were retrospective and conclusions contradictory.Adults resectable SLM randomly assigned to either simultaneous delayed resection of the metastases. The outcome was rate major complications within 60 days following surgery. Secondary outcomes included overall disease-free survival.A total 105 patients recruited....
T cell exclusion causes resistance to cancer immunotherapies via immune checkpoint blockade (ICB). Myeloid cells contribute by expressing signal regulatory protein-α (SIRPα), an inhibitory membrane receptor that interacts with ubiquitous CD47 control macrophage phagocytosis in the tumor microenvironment. Although CD47/SIRPα-targeting drugs have been assessed preclinical models, therapeutic benefit of selectively blocking SIRPα, and not SIRPγ/CD47, humans remains unknown. We report a potent...
Autoimmune hepatitis (AIH) is a rare disease characterized by an immune attack of the liver. This study consists comprehensive analysis alterations related to AIH at diagnosis, and during remission phase under treatment. A total 37 major lymphocyte populations were analyzed from peripheral blood new‐onset patients (AIHn; n = 14), with controlled (n 11), healthy subjects 14). Liver biopsy analyses performed complete phenotypic analysis. Four significantly altered in AIHn diagnosis compared...
To map the colorectal carcinoma (CRC) diseases with significant Wnt signalling pathway activation for delineating their clinicopathological and molecular profiles.Mapping is based on hierarchical clustering analyses of a series 283 CRCs. Data tabulated were histopathological patterns, immunophenotypic differentiation, RAS, RAF, CTNNB1 mutations microsatellite instability status, tumour-infiltrating lymphocytes (TILs) genetic setting. Beta-catenin expression in more than 10% cell nuclei...
Background: Whether synchronous colorectal cancer liver metastases should be resected simultaneously with primary or whether the procedure delayed remains controversial.