A5092083328- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Machine Learning in Bioinformatics
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- Genomic variations and chromosomal abnormalities
- Lung Cancer Research Studies
- vaccines and immunoinformatics approaches
- Chromatin Remodeling and Cancer
National Center on Addiction and Substance Abuse at Columbia University
2024-2025
Columbia University Irving Medical Center
2023-2024
Herbert Irving Comprehensive Cancer Center
2024
Abstract Lung cancer, the leading cause of cancer mortality, exhibits diverse histologic subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung but data from these are disparate, siloed, difficult compare in a centralized fashion. In this study, we established Cancer Autochthonous Model Gene Expression Database (LCAMGDB), an extensive repository 1,354 samples 77 transcriptomic datasets covering 974 genetically engineered (GEMM), 368...
9039 Background: Mutations(mt) in the Switch/Sucrose-Nonfermentable chromatin remodeling complex (SWI/SNF) are commonly found NSCLC and have been associated with worse prognosis. However, overall prognostic role of individual SWI/SNF subunits all NSCLCs oncogenic driver-positive (D+) driver-negative (D-) groups remains unclear. Our study attempts to clarify subunit alterations these populations. Methods: 42,379 tumor specimens were tested at Caris Life Sciences (Phoenix, AZ) NextGen...
Lung cancer, the leading cause of cancer mortality, exhibits diverse histological subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung but data from these are disparate, siloed, difficult compare in a centralized fashion. Here we established Cancer Mouse Model Database (LCMMDB), an extensive repository 1,354 samples 77 transcriptomic datasets covering 974 genetically engineered (GEMMs), 368 carcinogen-induced models, 12 spontaneous model....
Abstract Deleterious mutations in STK11/LKB1, KEAP1, and SMARCA4 have been shown to be associated with adverse response immunotherapy several lung cancer cohorts. However, the biological clinical implications of deletions these genes, which all reside on chromosome 19p (chr19p), has not extensively described. We sought first characterize association between immune infiltration copy number changes chr19p. To do this, we analyzed mutation, number, gene expression data from non-small cell...
<h3>Background</h3> Mutations in STK11/LKB1 and KEAP1 have been shown to be associated with adverse response immunotherapy several NSCLC cohorts, particularly lung adenocarcinoma (LUAD). However, the biological clinical implications of copy number alterations these genes, which reside on chromosome 19p (chr19p) along SMARCA4, not extensively described. We sought characterize landscape chr19p respect histology associations outcome (ICI)-treated patient cohorts. <h3>Methods</h3> analyzed...