A5103224088- Tuberculosis Research and Epidemiology
- Global Public Health Policies and Epidemiology
- Blood Pressure and Hypertension Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Diabetes Management and Education
- SARS-CoV-2 detection and testing
- Diabetes, Cardiovascular Risks, and Lipoproteins
- COVID-19 diagnosis using AI
- HIV/AIDS Research and Interventions
- Global Maternal and Child Health
- Gestational Diabetes Research and Management
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- HIV/AIDS Impact and Responses
- Health Promotion and Cardiovascular Prevention
- Respiratory viral infections research
- Radiation Therapy and Dosimetry
- Maternal Mental Health During Pregnancy and Postpartum
- Effects of Radiation Exposure
- SARS-CoV-2 and COVID-19 Research
- Iron Metabolism and Disorders
- HIV, Drug Use, Sexual Risk
- Palliative Care and End-of-Life Issues
University of Basel
2021-2025
University Hospital of Basel
2022-2024
Swiss Tropical and Public Health Institute
2021-2024
Universidad de la República de Uruguay
2023
Clinica Universidad de Navarra
2023
Texas Children's Hospital
2019-2022
Baylor College of Medicine
2019-2022
Community Health Partnership
2022
Universidad de Cantabria
2021-2022
International AIDS Society
2019-2020
Abstract In settings where access to expert echocardiography is limited, focused echocardiography, combined with artificial intelligence (AI)-supported analysis, may improve diagnosis and monitoring of left ventricular hypertrophy (LVH). Sixteen nurses/nurse-assistants without prior experience in underwent a 2-day hands-on intensive training learn how assess parasternal long axis views (PLAX) using an inexpensive hand-held ultrasound device Lesotho, Southern Africa. Loops were stored on...
The ability of interferon-gamma release assays (IGRAs) to detect latent tuberculosis (TB) infection before liver transplantation (LT)is not well established. aims this study were (1) compare the tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFT-IT) (a whole-blood IGRA) diagnose TB infections in patients awaiting LT (2) correlate results with severity disease. We conducted a prospective, cross-sectional who evaluated for between July 2008 2010. 95 included underwent 2-step TST...
There are no recent data on the prevalence of cardiovascular risk factors (CVDRFs) in Lesotho. This study aims to assess CVDRFs and their determinants. We conducted a household-based, cross-sectional survey among adults ≥18 y age 120 randomly sampled clusters two districts. Among 6061 participants, 52.2% were female median was 39 (interquartile range 27-58). The overall overweight, diabetes, elevated blood pressure (BP) tobacco use 39.9%, 5.3%, 21.6% 24.9%, respectively. 34.6% had none,...
Abstract Introduction Tuberculosis (TB) is a leading cause of mortality among people living with HIV (PLHIV). An invigorated global END TB Strategy seeks to increase efforts in scaling up preventive therapy (TPT) as central intervention for programmes an effort contribute 90% reduction incidence and 95% by 2035. TPT PLHIV should be part comprehensive approach reduce transmission, illness death that also includes active case‐finding prompt, effective timely initiation anti‐TB PLHIV. However,...
Abstract We conducted a household survey among 6061 adults in Lesotho to (1) assess the prevalence of moderate/severe mental health (MH) and substance use (SU) problems (2) describe MH SU service cascades, (3) predictors problem awareness (i.e., having MH/SU that requires treatment). Moderate/severe or was reported between 0.7% for anxiety past 2 weeks 36.4% alcohol 3 months. The treatment gaps were high both (62% gap; 82% gap) (89% 95% gap). Individuals with higher than median wealth had...
<title>Abstract</title> <bold>Background</bold>. Pain and its associated disorders are among the most common causes of disability contributors to healthcare costs globally. is understudied in Africa there no data on high-impact chronic pain from this region. In a population-based survey Lesotho, Southern Africa, we assessed prevalence unspecified pain, their determinants. <bold>Method</bold>. We conducted household-based, cross-sectional adults ≥18 years old 120 randomly sampled villages...
Abstract Introduction : National AIDS Programme in Myanmar has made significant progress scaling up antiretroviral treatment (ART) services and recognizes the importance of differentiated care for people living with HIV. Indeed, long centred around hospital reliant on physicians, country's HIV response is undergoing a process successful decentralization increasingly being integrated into other health as part systematic effort to expand access treatment. This study describes implementation...
Abstract Background Arterial hypertension (aHT) is the leading cardiovascular disease (CVD) risk factor in sub-Saharan Africa; it remains, however, underdiagnosed, and undertreated. Community-based care services could potentially expand access to aHT diagnosis treatment underserved communities. In this scoping review, we catalogued, described, appraised community-based models for Africa, considering their acceptability, engagement clinical outcomes. Additionally, developed a framework design...
The surge of the COVID-19 pandemic challenged health services globally, and in Lesotho, HIV tuberculosis (TB) were similarly affected. Integrated, multi-disease diagnostic proposed solutions to mitigate these disruptions. We describe evaluate effect an integrated, hospital-based COVID-19, TB screening model two rural districts during period between December 2020 August 2022. Adults, hospital staff, children above 5 years attending hospitals pre-screened for symptoms. After a positive...
Objectives To assess the real-world diagnostic performance of nasal and nasopharyngeal swabs for SD Biosensor STANDARD Q COVID-19 Antigen Rapid Diagnostic Test (Ag-RDT). Methods Individuals ≥5 years with compatible symptoms or history exposure to SARS-CoV-2 presenting at hospitals in Lesotho received two one swab. Ag-RDT from were performed as point-of-care on site, second swab used polymerase chain reaction (PCR) reference standard. Results Out 2198 participants enrolled, 2131 had a valid...
In Lesotho, the hypertension and diabetes care cascades are unknown. We measured awareness, treatment, control of among adults ≥18 years identified factors associated with each step cascade, based on data from a population-based, cross-sectional survey in 120 randomly sampled clusters districts Butha-Buthe Mokhotlong 1 st November 2021 to 31 August 2022. used multivariable logistic regression assess associations. Among participants hypertension, 69.7% (95%CI, 67.2–72.2%, 909/1305) were aware...
To study anemia in AIDS patients and its relation with socioeconomic, employment status educational levels.A total number of 442 who visited the Infectious Diseases University Hospital Buenos Aires, Argentina were included study. Patients dividied into two groups, i.e. one other without anemia. Anemia epidemiology relationship level, housing, job situation, monthly income, daily caloric intake weekly meat evaluated.Anemia was found 228 (54%). Comparing or anemia, a statistically significant...
Prepartum depression is associated with early adversity, pregnancy complications, preterm delivery, postpartum depression, and long-term effects on child neurodevelopment. The oxytocin (OXT) system affected by adverse experiences has been depression. In the current study, we investigated risk factors for prenatal depressive symptoms, mainly of childhood adolescence trauma, in combination presence certain variants polymorphisms OXT receptor (OXTR) genes. We hypothesized that trauma higher...
WHO introduced the STEPwise approach to surveillance (STEPS) monitor trends in non-communicable diseases. For arterial hypertension, STEPS protocol takes average of last two out three standard blood pressure measurements (SBPM). This study assesses diagnostic accuracy SBPM, same-day and next-day unattended automated measurement (uABP), with 24 h ambulatory (24 h-ABPM) as reference.This was done within a population-based household survey on cardiovascular risk factors districts Northern...
Objective To assess the utility of QuantiFERON®-TB Gold In-tube (QFT-GIT) for targeting preventive therapy in BCG-vaccinated contacts tuberculosis (TB), based on its high specificity and negative predictive value development TB. Methods We compared two screening strategies TB contact tracing consecutive periods: tuberculin skin test (TST) period, when all were screened with TST alone; QFT-GIT underwent QFT-GIT. Diagnosis infection among relied ≥5 mm while period either a positive or ≥15 was...