A5063256188- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Simulation-Based Education in Healthcare
- Respiratory Support and Mechanisms
- Neonatal Health and Biochemistry
- Retinopathy of Prematurity Studies
- Infant Nutrition and Health
- Neonatal and Maternal Infections
- Pregnancy and preeclampsia studies
- Congenital heart defects research
- Thyroid Disorders and Treatments
- Neonatal and fetal brain pathology
- Sepsis Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Cardiac Arrest and Resuscitation
- Preterm Birth and Chorioamnionitis
- Parathyroid Disorders and Treatments
- Electronic Health Records Systems
- Metabolism and Genetic Disorders
- Growth Hormone and Insulin-like Growth Factors
- Infant Development and Preterm Care
- Diabetes and associated disorders
- Patient Safety and Medication Errors
Azienda Ospedaliera Universitaria Pisana
2013-2024
University of Pisa
2009-2023
Ospedale Santa Chiara
2019-2022
Embryo and fetus grow mature over the first trimester of pregnancy in a dynamic hypoxic environment, where placenta development assures an increased oxygen availability. However, it is unclear whether how oxygenation changes later trimesters and, more specifically, last weeks pregnancy.Observational study that evaluated gas analysis umbilical cord blood collected from cohort healthy newborns with gestational age ≥37 weeks. Umbilical venous arterial levels as well fetal extraction were...
Objectives: Lutein and its isomer zeaxanthin (L/Z) function in the eye as antioxidant agents blue-light filters. Our aim was to evaluate whether their administration could help decrease occurrence of retinopathy prematurity (ROP) preterm infants. Methods: Infants with gestational age ≤32 weeks were randomly assigned receive a daily dose L/Z (0.14 + 0.006 mg) or placebo until discharge. Results: ROP similar (11/58; 19%) (15/56; 27%) groups, at each stage need surgery. Conclusion:...
Neonatal respiratory distress syndrome (RDS) is a major cause of mortality and morbidity among preterm infants. Although the INSURE (INtubation, SURfactant administration, Estubation) technique for surfactant replacement therapy so far gold standard method, over last years new approaches have been studied, i.e. less invasive administration (LISA) or minimally (MIST). Here we propose an originally modified MIST, called CALMEST (Catheter And Laryngeal Mask Endotracheal Surfactant Therapy),...
Background/Aims. IntraUterine (IUGR) and ExtraUterine Growth Restriction (EUGR) may induce reprogramming mechanisms, finalized to survive before after birth. Nutritional factors other environmental signals could regulate gene expression through epigenetic modification, but the molecular mechanisms involved are not yet well understood. Epigenetic be considered as a bridge between stimuli long lasting phenotype, acquired during intrauterine life first weeks of life. Our aim was investigate...
Retinopathy of prematurity (ROP) continues to threaten the vision premature infants. Premature exposure an environment that is richer in oxygen than uterus stops, or even regresses, retinal vasculature. This induces first avascular phase ROP, as confirmed by rodent models oxygen-induced retinopathy. The second proliferative reactive hypoxia-induced neovascularisation. Clinicians use defensive strategies reduce occurrence progression preventing preterm deliveries and providing minimal support...
An unexpected event is not rare in Neonatology and can be dramatic: the operators must act with right skills abilities shortest time. Often it a team effort each member trained adequately. According to "Swiss cheese" model by J. Reason, an accident never consequence of single error, but very final result chain misunderstandings, irregularities or negligence (cheese holes): several holes allow medical error. Therefore, we should avoid those our work. The clinical risk always around corner....
Respiratory problems are among the main causes of mortality for preterm newborns with pulmonary diseases; mechanical ventilation provides standard care, but long-term complications still largely reported. In this framework, continuous medical education is mandatory to correctly manage assistance devices. However, commercially available neonatal respiratory simulators rarely suitable representing anatomical and physiological conditions; a step toward high-fidelity simulation, therefore,...
Among neonatal epileptic syndromes, benign familial seizures (BFNS) are often due to autosomal-dominant mutations of the KCNQ2 gene. Seizures usually characterized by asymmetric tonic posturing with apnea onset in first 7 days life; they may even occur more than 10 times per day or evolve into status epilepticus. The delivery course our patient was uneventful and family history negative; on second life baby became pale, rigid apnoic during breastfeeding appeared jittery irritable when...
Maternal diet and early nutrition of newborns may affect the phenotype later in adulthood. Susceptibility epigenetic mechanisms to nutritional environment is a critical element neonatal development. Epigenetic could be considered as bridge between environmental stimuli long lasting phenotype. IC2, key region on 11p15, involved control growth regulates CDKN1C, PHLDA2 KCNQ1, inhibitor genes. Our aim was investigate relationship markers, postnatal growth.We enrolled 37 (gestational age at birth...
Abstract: Respiratory function is mandatory for extrauterine life, but sometimes impaired in newborns due to prematurity, congenital malformations, or acquired pathologies. Mechanical ventilation standard care, long-term complications, such as bronchopulmonary dysplasia, are still largely reported. Therefore, continuous medical education correctly manage devices assistance. Commercially available breathing simulators rarely suitable the anatomical and physiological realities. The aim of this...
Introduction: Oro-tracheal intubation requires a great deal of clinical experience to avoid serious complications. The level attention needed is even greater in the neonatal field due newborns' unique anatomical features. Therefore, specific skill trainers become fundamental training programs for residents and expert clinicians. However, current commercial devices are totally passive and, as result, operator receives no feedback on accuracy procedure. Materials Methods: An active sensorized...
In neonatal endotracheal intubation, excessive pressure on soft tissues during laryngoscopy can determine permanent injury. Low-fidelity skill trainers do not give valid feedback about this issue. This study describes the technical realization and validation of an active intubation trainer providing objective feedback. We studied expert health professionals’ performances in underlining chance for procedure retraining. identified most critical points epiglottis dental arches fixed commercial...
Abstract Background In recent years, medical training has significantly increased the use of simulation for teaching and evaluation. The retraining personnel in Italy is entrusted to program Continuous Education Medicine, mainly based on theoretical training. aim this study assess whether a new sensorized platform execution neonatal intubation procedure environment can complement experienced health professionals. Methods Neonatal tests were performed using commercial manikin modified...
An increased awareness on neonatal pain-associated complications has led to the development of pain scales adequate assess level experienced by newborns such as ABC score. A commonly used analgesic procedure is administer a 33% oral dextrose solution prior painful intervention. Although this very successful, not in all subjects it reaches complete efficacy. possible explanation for different response treatment could be genetic variability. We have investigated variability OPRM1 gene 1077...
Abstract The first thousand days of life from conception have a significant impact on the health status with short, and long-term effects. Among several anthropometric maternal lifestyle parameters birth weight plays crucial role growth neurological development infants. Recent genome wide association studies (GWAS) demonstrated robust foetal genetic background weight, however only small proportion hereditability has been already identified. Considering extensive number phenotypes which they...